DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and met-1

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	NP_491340.2	Gene:	met-1 / 172026	WormBaseID:	WBGene00016603	Length:	1604	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	141/754 - (18%)
Similarity:	250/754 - (33%)	Gaps:	243/754 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  2096 LPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSVTATPSPQ-PV--------PTVSPLANGFS 2151
            ||.:....|:.|....|..::...|.|       :....|:|| |.        |.:...||..:
Worm     8 LPKKRTEMVQTRRKTAAAVQDGGAVKE-------NKAKPPAPQTPTKRAKRGRPPKIKTDANTLN 65

  Fly  2152 TPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPS 2216
            ||         |..:|:..|:..|:      .|:::::...|....:|...:|.:|..|||..
Worm    66 TP---------STSSNLVDDKLLIE------SESQDSILTNEADSFLEKEVEEIEDSSDILPD-- 113

  Fly  2217 PGTHQIVAEDNLVKI-EPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQR---EKEIK 2277
                         || .||..|       :.|:|..|       ..:|||.:|:|:.   ..|:.
Worm   114 -------------KINSPEKPS-------VLVKRRSS-------TRLKVKTDEDEKDVPVNIEVA 151

  Fly  2278 QLQERQEHEQPKVEP-APVEPKLENTVAKAEPKVEPSQEIVSKKEPTKVEPKPGESLLRSTATVT 2341
            .|:|:    ..::|| :|..|:.......:.|.|||.::||...|||.                :
Worm   152 VLEEK----SIQIEPTSPAHPEDPQPSTSSLPLVEPIEDIVEPNEPTS----------------S 196

  Fly  2342 ATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAPVA---------------- 2390
            |.|..:.|...   |:.            |:||..|||..:......:|
Worm   197 ADPPVSNIKDE---DIK------------EEEPLIKKPASDESESMDIANSESGNDSDSSEADPR 246

  Fly  2391 TVPPVSVPPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEH-DIQERLLSFHAANISYLQSR 2454
            |:|..|:|                    |..|..|:..|....| |:.:               :
Worm   247 TIPSFSIP--------------------LPDTPPPNFAKRGEIHVDVDQ---------------K 276

  Fly  2455 NKKATAALTSASPSQKSNSSSGGSGTESKKSSKDK---------DEKRDKEKQLKKSKKEKKKSK 2510
            |.|.:.  .|.||.:::...|..:...|...|:.:         ....|....|.....|...::
Worm   277 NSKQSG--ESQSPWERAREKSASNPLSSPTMSRPRIHFLHPAYQSFTNDSVSPLPPPPPEPAPAR 339

  Fly  2511 DKE------------KQKAAVNVNSTSQIVDTKKKTTQPSKPDSKSSIAPVLVPPSLPVATANGK 2563
            :|.            |:.|.:.:..||..       .|||.|...||::     .|:.::..|..
Worm   340 EKVENGGPTTFKMTFKKAANIPILKTSAF-------EQPSSPPPSSSVS-----SSISLSEVNSS 392

  Fly  2564 TKHTAYNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSP---LHGTPPSTKKRQTNFEQE----- 2620
            |      ::..:.....|.....:..:...|.|.:...|   ....||:.:..:.:....
Worm   393 T------SIASESSPAKRSSNFDLTASNELPPPQMVELPKLSFFNMPPAVRSAEDDSAMTSEEPI 451

  Fly  2621 --LTKPNSQILSSSIL---------LNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQE---- 2670
              |..|||.......|         :..|:...|.:|...|..|  ..:::...|:..|:|
Worm   452 LLLRSPNSATPDDDALFLTTPPPPKMTESEIQALKVATEKVNQV--IARREDSEKDVRHREDRDD 514

  Fly  2671 -------------ATPASGGPMSLAAAIASGKLNAISRRRESMCGSRQQQALIAAALKKEKKEKK 2722
                         .|.:.....       .|:......||     :|:::..:.....:|::|.:
Worm   515 YDRRRDDRDRRSRKTDSERNDQ-------RGRQREDDERR-----AREREREVTKRHDREREEMR 567

  Fly  2723 KSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHIQK 2761
            ..|:||.|::|.|:::..:||.::.|:|:::.|....:|
Worm   568 LQKQKDEERRKKDEEERIQKENDEKKQKEDEAKMEEEKK 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
met-1	NP_491340.2	PHA03283	<219..308	CDD:223032	20/125 (16%)
		AWS	637..682	CDD:197795
		SET	694..810	CDD:214614
		tolA_full	<1300..>1375	CDD:274303
		WW	1366..1393	CDD:238122
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030