DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and DIDO1

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_011526806.1	Gene:	DIDO1 / 11083	HGNCID:	2680	Length:	2276	Species:	Homo sapiens

Alignment Length:	2605	Identity:	476/2605 - (18%)
Similarity:	790/2605 - (30%)	Gaps:	881/2605 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 TAARRQSVSAPSSRAVSLERKQHHQQLQHDVIGGGR--KAPTVIEYY----NKHGVNSIVGSSNN 633
            |.|:|:  .|..:.|..||.....|||...:...||  |....:|.:    .:.|..|:
Human    33 TIAKRE--GAGDAEADPLEPPPPQQQLGLSLRRSGRQPKRTERVEQFLTIARRRGRRSM------ 89

  Fly   634 LAQSNSMSNLAGPRSNSGSGFATTTP-TPATPLHLTPVNVPVHVEAAPPSSPALVKGSSQPPAQP 697
                        |.|...||..|:.| |.|.......|.......:.|.|:...||   :.||..
Human    90 ------------PVSLEDSGEPTSCPATDAETASEGSVESASETRSGPQSASTAVK---ERPASS 139

  Fly   698 QQQQQQAHPLGPNQLNANDEE---LYIEEV--------------RPVPVLTQDLRLQQLHAIMQD 745
            ::.:.     |.:..:.:|.:   |.::|:              ||:..:...||
Human   140 EKVKG-----GDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERPLKGIQSRLR---------- 189

  Fly   746 HTYASQQQQQQPQQAAG----DTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFG 806
                .:::::.|.:..|    ||.. |.....|:|:            ..||..:..|
Human   190 ----KKRREEGPAETVGSEASDTVE-GVLPSKQEPE------------NDQGVVSQAG------- 230

  Fly   807 QQIARSQADDDAHSAISSSSRMGLASTDI---DPGEETETAPEAEAEDDSVTRCICELTHDDGYM 868
                    .||..|.:.     |.|:.||   :||:.....||.|..|.:...|||...|::.:|
Human   231 --------KDDRESKLE-----GKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFM 282

  Fly   869 ICCDKCSAWQHVDCMGIDR------QNIPEEYMCELCQPRAV-DKARARALQRQKRKEHMLLVAT 926
            ||||:|..|.|.||:||..      :...|:|:|..|....| |:..:....:|:.|..     .
Human   283 ICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWR-----P 342

  Fly   927 QAANGAAAVAAGTTLSGGLGSGLPMSEELQHRLASGLNGGF--ATGTGMSKKSKKTKENSGSTST 989
            ..|:|....:.||.             |.:.....|:.|..  |......||.|..:...|...|
Human   343 GDADGTDCTSIGTI-------------EQKSSEDQGIKGRIEKAANPSGKKKLKIFQPGPGPVPT 394

  Fly   990 ----LKKTKKSAVGMG------------------GEKNASGSG-----TPTG------------- 1014
                |.:..:.||...                  |.....|.|     .|..
Human   395 QLPVLWQVLEIAVSRSISAFTLLHCISCKVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILKHAA 459

  Fly  1015 ------SSGKTSKKSSKRKSKSGGD-------GSSGG---GSSPALTAAEKHAANLRQ------- 1056
                  ||||..|...|.|.|...:       |:..|   .|.....|.||....:::
Human   460 ATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVKKAVVVPAR 524

  Fly  1057 ----------------WIENYEYAVTNHYSPELRARLHAIQKQPSLL-----QSIQNTENKALRQ 1100
                            |..::.|   |...||..|     ...||||     :..::.|..|...
Human   525 SEALGKEAACESSTPSWASDHNY---NAVKPEKTA-----APSPSLLYKSTKEDRRSEEKAAAMA 581

  Fly  1101 IQQQLSTAGSA--EQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRG----KYMLTTQFRTQNP 1159
            ..::.:..|||  :|...| .|:|...:...:::...:...|....:|    :..|:....:...
Human   582 ASKKTAPPGSAVGKQPAPR-NLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSATPSSGAS 645

  Fly  1160 TVNMNTPPPSNYLNSFKAHKTPGQ--FVFFYQLPGV-EAPMQTLRPD--GSVPQVAQQPPSYLKG 1219
            ......|.|:....:.|  |.||.  .|...:.|.| ..||.:..|.  |::.....||.|.::
Human   646 AARQAGPAPAAATAASK--KFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSAAPSQPNSQIR- 707

  Fly  1220 PEVCVDTRTYGNDARFVRRSC------RPN------------AELQHYFEKGTLHLYIV------ 1260
                          :.:|||.      |.|            .::..:.||...:|:.|
Human   708 --------------QNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYK 758

  Fly  1261 ----------------ALTHIRAQTEIT----IRHEPHDLTAVE---QKKSHAAVIQPTSTRCAC 1302
                            .|.|...:.||:    :|.:|.:|.:.|   .|:..|..:..:.|:
Human   759 SKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVMESRTK--- 820

  Fly  1303 DMGSDCLFALPL--AVQQQLQAPPTQPRSSHRNKAAAAAAAAAA---------------ANSAAA 1350
             :.::.....|.  |:.....:||.......:..|.|....:.|               .:.|..
Human   821 -LHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHL 884

  Fly  1351 IQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGLNSPQLGQLNLGFKTSVTATSLTAPVP 1415
            ..|...:..|...:|.....|..:..|.|...|..:...:|                   :||.|
Human   885 FDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDS-------------------SAPDP 930

  Fly  1416 GVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSV-----------SIPSPTPTQMQSP- 1468
                     :..|::.....::..|..:.|: .|:|.|:|           ..|.|:|.:..||
Human   931 ---------APDSADEVMPEAVPEVASEPGL-ESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPC 985

  Fly  1469 ------------TLQ-QHPQQIPQQQLSLLQRS---PTQQHQQQILAALPTPMLTPMLSPQ--LP 1515
                        |:. :.|:..|....:.:..:   |...|..:....:|.|:||.::.|:  |.
Human   986 PASCGSGVVTTVTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILA 1050

  Fly  1516 KPAQ--QQAHVVLPQSQQTSLLQQQQSQQSQEPLAV---------------IAAAAAAQQPMATY 1563
            ||:.  ...::.:|.|...|..:.:...:....|.:               :|.......|::..
Human  1051 KPSSSPDPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGC 1115

  Fly  1564 FVRQPQQQQQQQSPKPQALVAQQQHVVG-----------------AQQQQHFLQQQQKQQQQQMA 1611
            |       .......|..:     |:.|                 ..::...::.....:::::|
Human  1116 F-------DYLSEDLPDTI-----HIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVA 1168

  Fly  1612 ---------DEARMAVSALQTLHA---------------------------APTSHIVSPIKVAA 1640
                     ...|..|.|....|.                           :|..:|:  :.:..
Human  1169 YISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGLESPRPNII--LGLVI 1231

  Fly  1641 VQQQSQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQ---SPQRQQKPQ--PVQHQPQI 1700
            .|:..:|....:        ...:.::..:||.:::..|.||:   .||.::||.  |:......
Human  1232 CQKIKRPANSGE--------LDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAA 1288

  Fly  1701 VIST--GAQAIPATMP----TKLSSPTKSAAPVISNNNITVSAQSSVV-----GGKKT--PAKHP 1752
            |.:|  |:...|..:|    .|:.|..|.|||..:....|.:|.|:..     ...||  |.:|.
Human  1289 VSTTPPGSPPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHI 1353

  Fly  1753 QQQQQQQQQPVTPVSAATAPAATPSSSE----SKEDDVSASSTTTPTTR---TPAKDKPKQSRED 1810
            .|....:::...| ||...|.:|....:    :.||.|.|.....|..:   ..:|||..:..||
Human  1354 LQTLFGKKKSFDP-SAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEED 1417

  Fly  1811 RKLEAILRAIEKMEKQEARGKKDTRQSSGGKR-QASNSP-ASPNKRNSSNSISEDVETPTSTNSA 1873
            .      |..:..|:.:.....||:....|:| :...:| |:..:|   ..::.|.|..|....|
Human  1418 D------RPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAER---EEVAYDPEDETILEEA 1473

  Fly  1874 ----------AAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGESHALTNSES 1928
                      ..|..|||..:|.........|..|               ||.......| |.:.
Human  1474 KVTVDDLPNRMCADVRRNSVERPAEPVAGAATPSL---------------VEQQKMLEEL-NKQI 1522

  Fly  1929 EDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMG 1993
            |:|.:..:........|.|.:.:::||                       .|||.|.:
Human  1523 EEQKRQLEEQEEALRQQRAAVGVSMAH-----------------------FSVSDALM------- 1557

  Fly  1994 PLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQL 2058
                .|.|.|:.|. ||.                 ||| |||.|....||..|:.:..:.:..|.
Human  1558 ----SPPPKSSLPK-AEL-----------------FQQ-EQQSADKPASLPPASQASNHRDPRQA 1599

  Fly  2059 QRQPQGESLPAPALLKVEQFIHQAESTTAVPAR-EQLHLPLQNNSSVKKRWLRQAISEETTPVDE 2122
            :|            |..|....:.|..:.:.|| .|..||                        |
Human  1600 RR------------LATETGEGEGEPLSRLSARGAQGALP------------------------E 1628

  Fly  2123 LQQSQNQSVTATPSPQP---VPTVSPLANGFSTPLKKRRLVVVSNGTNVESDE-THIDVIGEPKD 2183
            ...|:...|...|.|.|   .|..||.|:|...|....:     :|...|..| |....:|:...
Human  1629 RDASRGGLVGQAPMPVPEEKEPASSPWASGEKPPAGSEQ-----DGWKAEPGEGTRPATVGDSSA 1688

  Fly  2184 EAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVE 2248
            .....|                     :|.:|..|.           ::|      ...::.|.|
Human  1689 RPARRV---------------------LLPTPPCGA-----------LQP------GFPLQHDGE 1715

  Fly  2249 REESQACDKFEEMVKVKREEEEQREKEIKQLQERQEHEQPKVEPAPVEPKLENTVAKAEPKVEPS 2313
            |:.. .|..|           ..::|.:...|    :|.|:            .:..|.....|:
Human  1716 RDPF-TCPGF-----------ASQDKALGSAQ----YEDPR------------NLHSAGRSSSPA 1752

  Fly  2314 QEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKK 2378
            .|....:||   :.:|||      .|....|....:..            ::||.:.:.||....
Human  1753 GETEGDREP---QARPGE------GTAPLPPPGQKVGG------------SQPPFQGQREPGPHA 1796

  Fly  2379 PKLESILPAPVATVPPVSVPPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSF 2443
            ..: |.|..|....|....||.|..:.|:.........|.......|..:           |.|.
Human  1797 LGM-SGLHGPNFPGPRGPAPPFPEENIASNDGPRGPPPARFGAQKGPIPS-----------LFSG 1849

  Fly  2444 HAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKK 2508
            ......|..||         ..|||.    ..|..|....:..:.||...:|
Human  1850 QHGPPPYGDSR---------GPSPSY----LGGPRGVAPSQFEERKDPHGEK------------- 1888

  Fly  2509 SKDKEKQKAAVN--VNSTSQIVDTKKKTTQPSKPDSKSSIA----PVL---------VPPS---- 2554
               :|.|.|..|  ..:.:|...|::.....|:..:.....    |:|         .|||
Human  1889 ---REFQDAPYNEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQRRPLLSQLKGPRGGPPPSQFGG 1950

  Fly  2555 -----------------LPVATANGK-------TKHTAYN------NVDQQQQQQMRRRTMSMCI 2589
                             ....||.|.       .:..|.|      .:..||.:..|..
Human  1951 QRGPPPGHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQPQQFEDQRVH------ 2009

  Fly  2590 TPVTPTPVVTPSP-----LHGTPP-STKKRQT----NFE---QELTKPNSQILSSSILLNSSKGL 2641
            :|...|....|:|     |.|:.| |.|..||    :|:   .::.||..:.|           |
Human  2010 SPPRFTNQRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPRPL-----------L 2063

  Fly  2642 GLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASG--------GPMS----LAAAIASGKLNAIS 2694
            .||...|            ||||: ..:||.|.|.        ||.:    .:|....||  ...
Human  2064 ELPSHPP------------QHRKD-RWEEAGPPSALSSSAPGQGPEADGQWASADFREGK--GHE 2113

  Fly  2695 RRRESMCGSRQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKD----------KE 2749
            .|.::..|.::::..:..  |::..|:..::.:..|.::.::::|:...||:|          ::
Human  2114 YRNQTFEGRQRERFDVGP--KEKPLEEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRD 2176

  Fly  2750 KDNKQ 2754
            ||:.:
Human  2177 KDSSR 2181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	19/48 (40%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	13/95 (14%)
DIDO1	XP_011526806.1	TNG2	<160..302	CDD:227367	44/188 (23%)
		PHD_DIDO1_like	266..319	CDD:277109	19/52 (37%)
		TFS2M	708..809	CDD:128786	18/100 (18%)
		SPOC	1093..1199	CDD:285043	11/117 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030