DRSC/TRiP Functional Genomics Resources

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Protein Alignment upSET and kmt2d

DIOPT Version :9

Sequence 1:NP_001261819.1 Gene:upSET / 39551 FlyBaseID:FBgn0036398 Length:3146 Species:Drosophila melanogaster
Sequence 2:XP_009295228.1 Gene:kmt2d / 100536523 ZFINID:ZDB-GENE-060223-2 Length:4967 Species:Danio rerio


Alignment Length:3001 Identity:599/3001 - (19%)
Similarity:975/3001 - (32%) Gaps:979/3001 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PAVSSSGGGSTSSINRIGVASGPQPPPPHIVIDGSSLSTQAQLRIMQRRMSISTRQILSASQSQS 77
            ||.|.|.|        :|:..|||    .||........|||:.:.|.:           ||:|.
Zfish  1959 PAFSCSPG--------VGIQMGPQ----QIVGQQHMTPQQAQVHLQQPQ-----------SQTQQ 2000

  Fly    78 INQSQKYAVRTAAGTGALAAGAASSGSSGQELIN-PQIYKIVTTDGSTSNVIIDASAAAPPHNSK 141
            :.......:....|.    ...|...|.|..|.| |.:..           |.|.|||..|....
Zfish  2001 VGADFNSRIALPPGN----QDTAVRPSDGPHLPNIPGMQD-----------ISDMSAAQDPALMS 2050

  Fly   142 LLLSNLTVLSKQAPVQGAAGQQQQQLNYL-GAKSLPYVSASPAKTQQQPQKFGSISAFKAQHQQQ 205
            |..|.|....::..::....:|:.|.|.| ..|..|.|| :||::.|.    |.:.||:....|:
Zfish  2051 LSPSELEKHRQRQRLREFLIRQKMQRNSLRQEKEAPVVS-NPAQSWQD----GEMPAFQQDKSQR 2110

  Fly   206 QQHPH----ATLQKVTLGSRV--------------------------ATRLQSYV-------PAS 233
            ...|:    |.:.:..|.||:                          |.|....|       |..
Zfish  2111 APPPYPQDRAAVTQAALASRMPLPMGVMDEKLCRPPPPGTPANMDPSALRQAGPVSQGMYPRPQF 2175

  Fly   234 PSQIMVQPA-----QPKYVNATATTIGGNAALLKKANQKITVKSVSNMSQQQQQQQQQQQQQLLQ 293
            |:|...|.|     ||..:.|..     ...|....|..:.::|:.||                 
Zfish  2176 PAQWQNQGAPRRFPQPSMIEAVP-----RQHLTTPINNPLNMQSMQNM----------------- 2218

  Fly   294 AQQLKTFI-TQQQQQQTYKAGAKAKFVK---------------QTTALSIAA--LPQQQQQTTYA 340
            ...|.|.. |..:..|::.:||..:|::               |...:..|.  ||||:....:|
Zfish  2219 PNPLTTVPGTGTEAVQSHVSGAPPQFIELRHNSQRMPPGPQFMQRAPIPRARMFLPQQEMNAAFA 2283

  Fly   341 KQSMVTTSTPAKVTKLNSKYV------------QQQISLPQGTQLQHKASPNVTGGGYLLQQSQA 393
            :|:: |:|..|....:....:            ||..:.|..:|||.:..|..|.          
Zfish  2284 QQNL-TSSLDASAVGMRDPRLGLQQGGMDLLMQQQSNAPPPQSQLQPQQVPTTTP---------- 2337

  Fly   394 AVGGTIKFVNSHGTVIQQHPQQQQ-ATKRTHYN--------------SSGSSDNEQHAVANSSLI 443
                  |...||.|  ||.||... .:::|..|              ..|.||    .||.:.:.
Zfish  2338 ------KTQISHTT--QQLPQTTSIGSQQTGVNPVDLPESDLVDAFAPKGLSD----PVAETGVE 2390

  Fly   444 TDDV------------------MIVNGTQMTDELSA-----------RILQSMAQKSFSQQQRFH 479
            .||:                  :..|...:.|.|::           .:.|...:..||.|.|..
Zfish  2391 DDDLGLDLDPDKGDDDLGNLDNLEANDPHLDDLLNSDEFDLLAYTDPELDQGDPKDVFSDQLRLV 2455

  Fly   480 QVPATG---SGN------MPPPTQIIYSNS----------TSNGAAASSPGGNASGNMLLAHY-- 523
            :....|   |.|      :.|..::...::          |.|.:|.::|...:|..:.|:..  
Zfish  2456 EAEVEGPVSSANVEVKVEVKPKVEMASQDTRTTATQPPLKTENSSAVNTPKVESSDVISLSSVKL 2520

  Fly   524 ------------QAAGTKPVSSASFITVTGTPPVTVATTPSVSISSHGFASGSAAISSYMSS--- 573
                        ||:....:|....:.::||.......||:.::::.........:.|...:   
Zfish  2521 EDKGLVEQPQSGQASVKDDISETVSVLLSGTKASNQPDTPTANLNTVRLGGIPFPLPSQADTLSF 2585

  Fly   574 -ATAARRQSVSAPSSRAVSLERKQHHQQLQH-DVIGGGRKA---PTVIEYYNKH----------- 622
             |||......|.|    :.|....||..... |.:....:|   |.:|:...:|           
Zfish  2586 PATAPHPDLGSDP----LGLPDSGHHSTADDLDKVESSLEASELPLLIQDLLEHEKKELQKQQQL 2646

  Fly   623 -----GVNSIVGSSNNLAQSNSMSN-LAGPRSNSGS-GFATTTPTPATPLHLTPVNVPVHVEAAP 680
                 |:.|.:.|..|..|....:| :..|:.:..| |..........|.|:.|......:.||.
Zfish  2647 SALQGGIGSQIHSIQNQQQPPQTTNQIMMPQHHHPSQGIVPQAGMVPRPPHMFPQQQQRLISAAM 2711

  Fly   681 PS--------SPALVKGSS----QPPAQPQQQQQQAHPLGPNQLNANDEEL--YIEE--VRPVP- 728
            ||        .|.:::|..    .|...||||..|...:|..|....|::|  ::.:  :.|:. 
Zfish  2712 PSPPHAAMGQQPGILRGGQPGRLHPGLAPQQQTTQPPHIGKQQNFFPDKDLDKFMTDDIIDPIAK 2776

  Fly   729 -----------VLTQD-------LRLQQLHAIMQDHTYASQQQQQQPQQAAGDTTNPGAAQQVQ- 774
                       ||.||       :..||:..:.|..|.|...:..||..|.|.:.....:.||| 
Zfish  2777 AKMIALKGINRVLAQDPMGVPPGMNRQQVSLLAQRLTSAPGNEDSQPPPAPGSSKEGEGSNQVQT 2841

  Fly   775 --QPQQWSLGGIGVTVSGSQ--------GTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMG 829
              .|.|:     |:.....|        .|...:.....:..:||.       ||    ..||..
Zfish  2842 RPNPPQF-----GIINDAEQHQYEEWLVHTQQLLQMQLKFLEEQIG-------AH----RKSRKA 2890

  Fly   830 LASTDIDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEY 894
            |.:......:......||:||.   .:.:.|                         ::..|.:: 
Zfish  2891 LCAKQRTAKKAGREFAEADAEK---LKLVTE-------------------------EQSKIQKQ- 2926

  Fly   895 MCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGLPMSEELQHRL 959
                     :|:.      |:::|||..|:|..                       .|::.||:.
Zfish  2927 ---------LDQV------RKQQKEHTNLIAEY-----------------------RSKQQQHQQ 2953

  Fly   960 ASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGM--GGEKNASGSGTPTGSSGKTSKK 1022
            .|.:   .|.|           .::.:...|.|.....:|.  ||...|:   .|.|  |...:.
Zfish  2954 GSSM---LAPG-----------PSTPAPHMLSKMPGQMIGQPPGGMPQAA---MPPG--GMPIRM 2999

  Fly  1023 SSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLL 1087
            ...:..         |.:.|:|..    .|...|....:........:|:.|    .:|::...:
Zfish  3000 PQMQPF---------GAAQPSLPL----GAGPVQPPPGFFPQGPGPQAPDPR----VLQERQYKM 3047

  Fly  1088 QSIQNTENKALRQIQQQLSTAGS--AEQLEQRAQLIPYAG------AKVLISSVDLSPHAPIHEL 1144
            |.:|.     ::|.||||..|..  :.|.:|...:....|      |:||:.|:. .|:..    
Zfish  3048 QMVQK-----MQQQQQQLMMAQQPMSHQPQQPGIMNQQPGAMGSQPAQVLMGSLG-QPNLQ---- 3102

  Fly  1145 RGKYMLTTQFRTQNPTVNMNTPP--PSNYLNSFKAHKTPGQFVFFYQLPGVEAPMQTLRPDGSV- 1206
              :.::.:|   ||....:.|||  ..|.......|...||     |:... |.:...:|.|.| 
Zfish  3103 --QGLINSQ---QNQQGLVQTPPGMMGNQALGQTQHNVMGQ-----QMTQT-ANLMAGQPQGMVG 3156

  Fly  1207 -PQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLYIVALTHIRAQTE 1270
             .|:.||    |:.|:|.:|                     ||    |.:..::|          
Zfish  3157 NQQIVQQ----LQRPQVLMD---------------------QH----GPVGQHVV---------- 3182

  Fly  1271 ITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKA 1335
               |..|..||..:|.                      :.|..:.:.||.|              
Zfish  3183 ---RGPPTQLTPQQQS----------------------VMAQRMLMSQQQQ-------------- 3208

  Fly  1336 AAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMGLNSPQLGQLNLG 1400
                   .||.|.|.:|....|.:                        ..|.|.:.||       
Zfish  3209 -------NAAKSLAQLQQQQILQL------------------------KQQAGPSEPQ------- 3235

  Fly  1401 FKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLH-----DSGICTSSSSPSVSIPSP 1460
                   .:|.||       :|||:...:.|   :......|     |.|:.:..:.|....| |
Zfish  3236 -------RALEAP-------SSGGNQGVAEN---LQQGVQDHQNPNKDGGLLSPKTPPQQGGP-P 3282

  Fly  1461 TPTQMQ--SPTLQQHPQQIPQQQLSLLQRSPTQQHQ--QQILAA-----LPTPMLTPMLSPQLPK 1516
            ||.|||  |...||.....||||.:.|.:..|.|.|  |.|..|     :......|.|..|.|:
Zfish  3283 TPLQMQQGSSGEQQCVVGQPQQQHAFLGQQQTAQPQTNQNIGVAEQHGFVDNQQAGPHLKVQPPQ 3347

  Fly  1517 PAQQ-----QAHVVLPQ-SQQTSLLQQQQSQQ--SQEPLAVIAAAAA---------AQQPMATYF 1564
            |..|     |..:.:.| .||...:.|||:.|  :|:|..|....:.         .||.:.|..
Zfish  3348 PQMQIGLQTQTKIQIKQEDQQMCFMAQQQAGQIAAQQPQGVAVQNSGQTMGNITNQQQQALLTQQ 3412

  Fly  1565 VRQPQQQQQQQSPKP-------------QALVAQQ---QHVVGAQQQQH---FLQQQQKQQQQ-- 1608
            :..|:.||...:.:|             ||.:||.   :|:..:||.|.   .|.|:|.||.|  
Zfish  3413 MGIPRAQQMMMTQRPGAPAGQIRTSINIQAFIAQNPQLRHLTPSQQLQQIQAMLAQRQLQQGQML 3477

  Fly  1609 --QMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQQ----------QNTHQQPHNQ 1661
              |...:.:|....||.....|...::            :.||||          .:|.|||   
Zfish  3478 RLQGQAQGQMRPQVLQGPSVGPRIPVI------------ETQQQQHRFGLAGKHGSSTQQQP--- 3527

  Fly  1662 QAVQQQSNQLQQ---------QQSQQ---PNYPQSPQRQQKPQPVQ-HQPQIVISTGAQAIPATM 1713
            ..::|||....|         ||..|   |.|..|.|:||..|..| ||.|::  .|....|...
Zfish  3528 GVIRQQSGMAPQFHQGVIGAMQQPSQGPLPQYINSAQQQQMIQQQQVHQHQMM--RGQVPRPIMG 3590

  Fly  1714 PTKLSSPTKSAAPVISNNNI-------TVSAQSSVVGGKKTPAKHPQQQQQQQQ----QPVTPVS 1767
            ..:.::|...|.|:.....:       .:|.|..:|...:||   |..|..|||    ..::|..
Zfish  3591 QVRNTAPGHLARPMSPRQLLGQGSPGSPLSNQQRLVRMSQTP---PGTQHLQQQTHGTTALSPFQ 3652

  Fly  1768 AATAPAATPSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKK 1832
            |:.:.|.:|:.|            :.|...:|:.:||:..  :..|.:.|.:..:.|  ...||.
Zfish  3653 ASPSHAGSPAGS------------SVPEAGSPSLNKPEPG--NMALSSNLSSPSRPE--GIVGKS 3701

  Fly  1833 DTRQSSGG-----------KRQASNSPA--------------SPNKRNSSNSIS-EDVETPTSTN 1871
            .....:||           |.|:.|:.|              :.|:..:|..|| .....||...
Zfish  3702 SPFSQTGGLIPSPLRSPTAKTQSPNTEALSAPFPLNGPSSQVAQNQAPNSGQISGGHTSQPTQMP 3766

  Fly  1872 SAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIVVESDGES---HALTNS------E 1927
            |.......:|.|:.  .|.:..:|..:........||      |..|||   ..:.||      :
Zfish  3767 SEMCKMTLQNIKQE--PREVQCDTGNIVETHSDGIKR------EISGESVSGSGIVNSAVGSRNQ 3823

  Fly  1928 SEDQGQHPQSHHSGSEDQAAGLLLALAHNNS------SPNEPFKSPLS---------QSHSLPAT 1977
            :.|.|...|...:|.:     ||..|....:      .|::...:.::         ....|..|
Zfish  3824 AGDIGSQIQRTETGQQ-----LLQKLLRTKNLQVAAQRPSDGIHNEINGHINNKLAMLEQKLQGT 3883

  Fly  1978 PASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDS 2042
            |.::.....|.:.|  |:.:....|.|..     :.|....||||                    
Zfish  3884 PRNMEDLQSLTKRA--PIVKAKRTAKAGE-----RGPNSRKKTKK-------------------- 3921

  Fly  2043 LVQAAMSEINGEREQLQRQ-PQGESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKK 2106
                   |..|:.|.:.:| .||.|| .|.:            ..::.|...|..|..::.:..|
Zfish  3922 -------EEVGKTEAIMKQLKQGLSL-LPLM------------EPSITASLDLFAPFGSSPANAK 3966

  Fly  2107 RWLRQAISE---ETTP--VDELQQSQNQSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGT 2166
            ..|:.:...   :..|  ..:|....|.|...|| |..:|...|       |..:.:|:   ||.
Zfish  3967 TQLKGSFGNAILDNIPDYYSQLLTKNNLSNPPTP-PSSLPPTPP-------PSVQHKLL---NGV 4020

  Fly  2167 NVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRS-PSPGTHQIVAEDNLVK 2230
                  |.::.:.|.:.|       ||...:......|:...||||.: |:|..:|  .||  ::
Zfish  4021 ------TQVEELAEGQKE-------TEASEDTIGSVPEEVKSVDILAALPTPPHNQ--NED--IR 4068

  Fly  2231 IEPEDTSAAADDVKIDVEREESQACD---KFEEMVKVKREEEEQREKEI---------------- 2276
            :|.:|.|.|:|.: :.....|||..|   :|..::..|.||||:....:                
Zfish  4069 MESDDDSDASDSI-VPASSPESQLGDETTRFPSLLDPKEEEEERAISPVIPIIPRSTIPNFSETK 4132

  Fly  2277 -------KQLQERQEHEQPKVEPAPVEPKLENTVAK------------AEPKVEPSQEIVSKKEP 2322
                   |.:....:.::.|.....|...|.:..||            ...::..|.|:...:.|
Zfish  4133 PFESVDGKVVASSSQWDKAKSNEVSVTFMLSSAAAKNLNTVMLAVAQLLHIRMPSSYELAFPQSP 4197

  Fly  2323 TKVEPKPGESLLRSTATVTATPTAATIAATT-------LLDVSKVAFKTRPP------LKLEDEP 2374
            .:|...||:      ...::.|...|.|:.:       ..|||......|..      :|.|.:.
Zfish  4198 GRVGAGPGK------VPDSSNPGLKTDASVSNDAEWLKQFDVSLPGCTLRKQVDILALIKQESQE 4256

  Fly  2375 QKKKPKLE--------------SILPAPVATVPPVSVPPIPAAS-----NATTSAVTNTAAASLT 2420
            |:.||...              .::|..|:..|..|.||.|:::     |.|.......:.|::.
Zfish  4257 QEDKPAQHCYMTNVSDLDVRHLPVIPVEVSPPPSPSPPPPPSSTVAEPENTTQPEPKPESEATVQ 4321

  Fly  2421 TTTAPSSTKNL---TEHDIQERLLSFHAANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTES 2482
            ||::||::.:.   ||..:::   ..|.:.::.....::.|...:....|.::.::.:.....:|
Zfish  4322 TTSSPSASPSAPVKTEILVKQ---ESHCSPVTVEPESHEPAVLPIAVPPPQEQPSAPASSPPLDS 4383

  Fly  2483 K------KSSKDKDEKRDKEKQLKKSKKEK-------------KKSKDKEKQKAAVNVNSTSQIV 2528
            .      ||.|.:......|:|..|.||.|             :|...|::....|     |:::
Zfish  4384 PTIEISLKSIKHRSRPLSDEEQRPKVKKWKGLRWKRLQIVITIRKGGSKKESSREV-----SELM 4443

  Fly  2529 DTKKKTTQPSK 2539
            :..:.|.:|.|
Zfish  4444 ERLRITLKPDK 4454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
upSETNP_001261819.1 PHD_MLL5 856..899 CDD:277025 2/42 (5%)
SET <1221..1273 CDD:214614 6/51 (12%)
kmt2dXP_009295228.1 PHD_SF 122..205 CDD:304600
PHD1_KMT2C_like 218..263 CDD:276984
PHD_SF 265..310 CDD:304600
PHD 346..391 CDD:214584
PHD_SF 821..871 CDD:304600
PHD5_KMT2C_like 872..918 CDD:276988
PHD5_KMT2D 949..999 CDD:277074
HMG 1473..1528 CDD:197700
Med15 3305..>3717 CDD:255446 108/447 (24%)
PHD_SF 4462..4568 CDD:304600
FYRN 4612..4662 CDD:283589
FYRC 4668..4749 CDD:283590
SET 4828..4949 CDD:214614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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