DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and setd5

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_004914165.1	Gene:	setd5 / 100145036	XenbaseID:	XB-GENE-5843081	Length:	1459	Species:	Xenopus tropicalis

Alignment Length:	1672	Identity:	326/1672 - (19%)
Similarity:	534/1672 - (31%)	Gaps:	534/1672 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   785 GVTVSGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLASTDIDPGEETETAPEAEA 849
            |....|.:|.|.||....:|.........|.....:.|..:...|:.|.|   .||.....::.:
Frog    47 GTQSHGYRGLPYAVSMDHNYGAPPPPTPPASPPVQAVIPRAEHNGIHSPD---EEENSGESDSSS 108

  Fly   850 EDDSVTR-CICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQPRAVDKARARALQ 913
            |.:.:|. |.|.|: .:|::|.|:||..                             ..|.:.:|
Frog   109 EGEDLTNWCQCSLS-QEGFLIKCEKCKG-----------------------------ANRGKVIQ 143

  Fly   914 RQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGL-PMSEEL----------QHRLASGLNGGF 967
            ...||:                   ..:|||..|.. ...|||          ||...|......
Frog   144 LNHRKQ-------------------DNVSGGESSATESWDEELSPSTVLYTATQHTPTSITLTVN 189

  Fly   968 ATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTPTGSSGKTSKKSSKRKSKSGG 1032
            ..|....||.||:.|.:.:|...||.|....|                    |:||.:.|:
Frog   190 RVGKSKPKKRKKSTEKARTTPKAKKIKAFREG--------------------SRKSLRMKN---- 230

  Fly  1033 DGSSGGGSSPALTAAEKHAAN----LRQWIENYEYAVTNHYSPELRARLHA-IQKQPSLL----- 1087
                  ..|.|.|..|....:    :|.|.:.||.|.||.||.:::..|.: ::....|:
Frog   231 ------SPSDAHTLDENTTEDWENRIRLWTDQYEEAFTNQYSADMQNLLESHVRSSKELIGKAAA 289

  Fly  1088 -QSIQNTE---NKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLISSVDLSPHAPIHELRGKY 1148
             ::|:.||   |..:...|.||. .|...::::.        .|:|.::.||:|:..:.|.|||.
Frog   290 GETIKKTELACNNTVVGSQMQLQ-LGRVTRVQKH--------RKILRAAKDLAPNTLVIEYRGKV 345

  Fly  1149 MLTTQFRTQNPTVNMNTPPPSNYLNSFKAH--KTPGQFVFFYQLPGVEAPMQTLRPDGSVPQVAQ 1211
            ||..||.     ||              .|  |.|..||.||
Frog   346 MLRQQFE-----VN--------------GHFFKRPYPFVLFY----------------------- 368

  Fly  1212 QPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLYIVALTHIRAQTEITIRHE 1276
               |...|.|:|||.||:||||||:||||.||||::|...:|.:||.|..:..|....|:||..:
Frog   369 ---SKFNGLEMCVDARTFGNDARFIRRSCTPNAEVRHMISEGMVHLCIYTVAAIAKDAEVTIAFD 430

  Fly  1277 PHDLTAVEQKKSHAAVIQPTSTRCACDMGS-DCLFAL--PLAVQQQLQAPP-------------- 1324
             .|.:....|           ..|||..|: :|....  |:.:.....|||
Frog   431 -FDYSNCNYK-----------VDCACHKGNRNCPVQKRNPIPIDLPPPAPPPALSIGAETRRRKA 483

  Fly  1325 -----------TQPRSSHR-NKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRS 1377
                       .:.|::|: .:......|..|.|...|.:...     |..||     |....|.
Frog   484 RRKELEQQGFVVEDRANHQTGEPPKTPVADVATNDQEAQEEKK-----AEPAA-----PVIEERR 538

  Fly  1378 TSSSGESSQMGLNSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLH 1442
            ......:.::.|..|::.......|....::.:.|..|  ...|......::||:.
Frog   539 RKRKDPALELTLPEPEVPSTVEDVKPPEESSPVEATDP--EAENMEAEEIAANNNV--------- 592

  Fly  1443 DSGICTSSSSPSVSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLT 1507
              |:.|..||.:..:.:..|.....|.....|:  |:.::|..:.:..|:.::|..|.
Frog   593 --GVNTRRSSQAAEVVAEKPAAKPIPPKSSRPR--PKSRMSRYRSASAQRLRRQRQAV------- 646

  Fly  1508 PMLSPQLPKPAQQ--QAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQ 1570
                      |||  |.|.|..:.                  ..:|::|...:|.|...|.|...
Frog   647 ----------AQQVEQVHTVAEEG------------------GAVASSANTTEPGAAESVGQSGN 683

  Fly  1571 QQQQQSPKPQALVAQ------QQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVS---ALQTLHA 1626
            .|...||......:|      :.|.........:|..:.::|...:....|:...   ...||:.
Frog   684 PQGADSPAVSQTASQPSRANLKYHKTKKYLVTEWLNDKVEKQDCPIDHPLRITTDPTVLATTLNM 748

  Fly  1627 AP-TSH----IVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQ 1686
            .| .||    .::|...........|:::::............::...|.......||
Frog   749 LPGLSHSPSICIAPKHYVRFVSPFMPERRRRPPKADGTYGSCKKRWMKQAMDDLKTQP------- 806

  Fly  1687 RQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTK--SAAPVISNNNITVSAQSSVVGGKKTPA 1749
                ..|.|.:.|.:..:...::.:|..|..::|.|  ....|:..|:.|:::..|.|    ||
Frog   807 ----VSPPQEKTQTLYQSNESSLSSTNSTGTTAPFKKWKMKYVLEENSGTLTSPLSFV----TP- 862

  Fly  1750 KHPQQQQQQQQQPVTPVSAAT---AP-AATPSSSESKEDD--------------VSASSTTTP-- 1794
                        |:.|.|:.|   :| ..|||||...|::              ::||...||
Frog   863 ------------PLLPNSSTTDSLSPLQTTPSSSLPGEEESRFGYGLMFSPIPSLAASRCNTPLQ 915

  Fly  1795 --TTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKRQASNSPASPNKRNSS 1857
              ...:| :..|....|....|..||...::.|.....              |.|...|::.:..
Frog   916 FENISSP-ETSPAHRPESLSPEPCLRPDLEIPKASFLD--------------STSEICPDQSSIV 965

  Fly  1858 NSISEDV-ETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNKRRKSIV-------- 1913
            ..::|.. ::|:::.:...|.:              ||..|.||.|.:..:..:..|
Frog   966 TGLAELAGQSPSTSVTYGGATE--------------NNLMGKGSEGSTLLRTSEQAVRTEFSLMY 1016

  Fly  1914 --------VESDGESHALTNSESEDQGQHPQSH-HSGSEDQA------AGLLLALAHNNSSP--- 1960
                    ..:||   :|..|....:.:..||. :.||..:|      .|||...|..:.||
Frog  1017 AFSPLNAMPRADG---SLRGSPLVGERKPSQSEAYCGSPVEAYHGKLGTGLLKEAAQGSMSPCSE 1078

  Fly  1961 -------------------------------NEPFKSPLSQSHSLPATPASVSSACLLIEAAMGP 1994
                                           .|...||:........||...||...|.:..:..
Frog  1079 RICDGIRSSPQNPPQRKKVSLLEYRKRKQEAKEVISSPVGDIFRCVGTPTRQSSNGSLSDTDLSS 1143

  Fly  1995 ---LQQQPAPAS-----ASPSLAEFK--YPP---------GGAKTKKSLMSSWFQQAEQQHASGL 2040
               ||.|.:|.|     |.||:.:.:  .||         ..:|..:::.|.|......:.....
Frog  1144 SLHLQAQSSPHSGFSSPAHPSMPQIEDVSPPDTKTSGPSVSHSKHSENISSRWMVPTSVERLREG 1208

  Fly  2041 DSLVQAAM---------------SEINGEREQLQRQPQ--------GESLPAPALLKVEQFIHQA 2082
            ..:::..:               .:|:.:|:..:..|:        |.|:.:|:....:|.: |.
Frog  1209 QGILERVLRSGVKVSHIGEPSPSRDISADRDPEEGDPEMPSMAVTKGPSVYSPSRYSYQQVL-QC 1272

  Fly  2083 ESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDELQQSQNQSV-TATPSPQPVPTVSPL 2146
            :|    |..|.|:|..|::|..:               ....||...|. |...:..|:|..|.:
Frog  1273 DS----PQPESLNLLSQSSSPFR---------------GPAAQSHGYSYRTPQRAGHPLPDSSVI 1318

  Fly  2147 ANGFSTP-------------------LKKRRLVVVSNGTNVESDETH------------------ 2174
            :..:|:|                   ...::|...:.||.......|
Frog  1319 SGSYSSPAHTASMDSPTTQCSGGPGFYNSQQLYGSNAGTGQPRKSFHHRGPSCEASPAQLLRTDS 1383

  Fly  2175 IDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQ 2221
            :....:|...|..|.:.|          |....|...:..|||| ||
Frog  1384 LPTDSQPSTGASSNSSTT----------QGSRSDSRTITLPSPG-HQ 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	8/43 (19%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	27/51 (53%)
setd5	XP_004914165.1	SET_SETD5	306..455	CDD:380958	64/214 (30%)
setd5	XP_004914165.1	rne	<510..699	CDD:236766	44/248 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2523
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004035
OrthoInspector	1	1.000	-	-		otm48873
Panther	1	1.100	-	-	O	PTHR46462
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150