Protein Alignment upSET and phf20

DIOPT Version :9

• Sequence 1: NP_001261819.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Sequence 2: XP_004918557.1
• Gene: phf20 / 100126218
• XenbaseID: XB-GENE-960341
• Length: 1098
• Species: Xenopus tropicalis
• Alignment Length: 1105
• Identity: 210/1105 - (19%)
• Similarity: 374/1105 - (33%)
• Gaps: 366/1105 - (33%)

  Fly   198 FKAQHQQ-QQQHPHATLQKVTLGSRVATRLQSYVPASPSQIMVQPAQPKYVNATATTIGGNAALL 261
            ||.|.:. :..||              .:.:|..|...|.   ||.:.|     ...:...:.:.
 Frog   166 FKEQRKSAENTHP--------------VKEKSIAPEKKSS---QPEREK-----KPVVSEKSKIP 208

  Fly   262 KKANQKITVKSVSNMSQQQQQQQQ--QQQQQLLQAQQLKTFITQQQQQQTYKAGAKAKFVKQTTA 324
            :|...|...:...|:|:.:::...  :|:::...::.|||.:....:::        |..:.|||
 Frog   209 EKNGVKNEKEDKENISENERESSGDCRQEERSTPSESLKTPLENGDRRK--------KRDRPTTA 265

  Fly   325 LSIAALPQQQQQTTY---AKQSMVTTSTPAKVTKLNSKYVQQQISLPQGTQLQHKASPNVTGGGY 386
            ....::.|..|..|.   .::..:.:..|.|.::|:.   ..:.|||        ||.||
 Frog   266 PPSDSVSQTLQPVTLELRRRKISIGSEIPTKRSRLDK---STKKSLP--------ASENV----- 314

  Fly   387 LLQQSQAAVGGTIKFVNSHGTVIQQHPQQQQATKRTHYNSSGSSDNEQHAVANSSLITDDVMIVN 451
                         |..|  |...:.||:                             .||:
 Frog   315 -------------KVEN--GLPEELHPE-----------------------------ADDI---- 331

  Fly   452 GTQMTDELSARILQSM-AQKSFSQQQRFHQVPAT---GSGNMPPPTQIIYSNSTSNGAAASSPGG 512
             .:..|.||...|.|. :|:..|:.:.....|.|   |....|..|    |..|......|....
 Frog   332 -CETEDTLSPLSLSSCESQEKLSENEEKTTAPLTEEEGVSQEPNVT----SMETQEVHTESLTPS 391

  Fly   513 NASGNMLLAHYQAAGTKPVSSASFI--TVTGTPPVTVATTPSV---------SISSHGFASGSAA 566
            |..        |:....|..:..|:  :|...|    ::||.:         |..:....|..|.
 Frog   392 NTE--------QSEAKTPTETDDFVELSVNDVP----SSTPDMKAEENNSTESKQNQEVPSVPAP 444

  Fly   567 ISSYMSSATAAR--RQSVS-------APSSRAVSLERKQHHQQLQH-DVIGGGRKAPTVIEYYNK 621
            :.....|.|:|:  |:.::       .|:.:||::|...:..:.:. |.....||| .::.|:.|
 Frog   445 MKRIPRSDTSAKYSREPLTHALKKSDDPAPKAVTMELDPNRFKCKFLDCSKSFRKA-KLLHYHMK 508

  Fly   622 --HGVNSIVGSSNNLAQ-SNSMSNLAGPRSNSGSGFATTTP----TPATPLHLTPVNVPVHVEAA 679
              ||:.......:.:.: ..:..:||..:|:.      .||    |.:..|| ||:.:.:.
 Frog   509 YFHGIEKAEQDQSPVTRHMQTRGSLAHEKSSQ------ETPKRRRTTSGSLH-TPLQISLR---- 562

  Fly   680 PPSSPALVKGSSQPPAQPQQQQQQAHPLGPNQLNANDEELYIEEVRP-VPVLTQDLRLQQLHAIM 743
              |||               |..:|..||..:.::..........|| :...:::.::|:.|: .
 Frog   563 --SSP---------------QDGKAERLGEKRRHSMHASYTSNSHRPSLKEKSKENQIQKTHS-K 609

  Fly   744 QDHTYASQQQQQQPQQAAGDTTNPGAAQQVQQPQQWSLGGIGVTVSGSQGTPTAVGGYCSYFGQQ 808
            .|....|.:.:::.::...|:.|..|.::.::.::..|..     |||:.. ..:....|....|
 Frog   610 SDKQSESVKDKEKIREKLKDSLNLKARKKKKKKKKPRLEN-----SGSEEN-LDISKELSPKKTQ 668

  Fly   809 IARSQADDDAHSAISS----SSRMG----------------------LASTDIDPGEE---TETA 844
            :.:...|....|.:.|    ||..|                      |.|.|.|..||   |...
 Frog   669 VIKQSPDFKPSSQVKSAPLRSSEHGRRKDTGRLSDEDTLSDSCTESLLWSDDDDNNEEIDVTNAD 733

  Fly   845 PEAEAE--DDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPEEYMCELCQ------- 900
            .|.|.|  |..:.||:||:..::.:||.|::|..|||..|||:...|:||:|.|.:||
 Frog   734 EELEEEPGDCEIVRCMCEVQDENDFMIQCEECLCWQHGVCMGLLEDNVPEKYKCYICQDPPGQRL 798

  Fly   901 -------PRAVDKARARAL----QRQKRKEHMLLVAT---------------------------- 926
                   ...:||.....|    :....:....:|||
 Frog   799 SLKYWYDKEWLDKGHMHGLSCLEENYSHQNARKIVATHQLLGDVQRVIEVLHGLQLKMSILQSKE 863

  Fly   927 -------------QAANGAAAVAAG-------------TTLSGGLG--SGLPMSEE--------- 954
                         ||.|....:...             .|.:|.:.  |.:|..||
 Frog   864 HPDLKFWGQPWKQQAVNDKCYIRRSLEENSCKGDSTNHRTYNGAVDKPSPIPSVEESYITSEHCY 928

  Fly   955 ---------LQHRL-----ASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKSAVGMGGEKN 1005
                     ::.||     :|.|:||.       ::.::::|:|           .|..:|.|.:
 Frog   929 QKPRTYYPAVEQRLVVETRSSALDGGV-------ERIRQSREDS-----------IAERLGWELD 975

  Fly  1006 ASGSGTPTGSSGK-------TSKKSSKRKS--KSGGDGSSGGGSSPALTAAEKHAANLRQWIENY 1061
            .....|.:.|...       .||::..::|  ....|.|.||.||..     :...||...:|:.
 Frog   976 RELIKTESESKHNYCKVRECLSKRNPPQESTHPQPTDISDGGVSSQI-----QWQLNLLAHLESL 1035

  Fly  1062 EYAVTNHYSPELRARLHAIQKQPSLLQS-------IQNTENKA-----LRQIQQQLSTAGSAEQL 1114
            :..||:        |:..|:|:..:|:|       ::..|..|     ..:|:|.|:..|..||:
 Frog  1036 QDEVTH--------RMDFIEKELDVLESFLDYTGELEPPEPLARLPQLKHRIKQLLTDLGKVEQI 1092

  Fly  1115  1114
             Frog  1093  1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	19/42 (45%)
		SET	<1221..1273	CDD:214614
phf20	XP_004918557.1	Tudor-knot	13..57	CDD:288553
		TUDOR	90..135	CDD:119391
		DUF3776	180..252	CDD:289391	14/79 (18%)
		PHD_PHF20	747..790	CDD:277104	19/42 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.040