DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment upSET and nsd3

DIOPT Version :9

Sequence 1:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster
Sequence 2:	XP_005155379.1	Gene:	nsd3 / 100006350	ZFINID:	ZDB-GENE-050324-2	Length:	1563	Species:	Danio rerio

Alignment Length:	1701	Identity:	297/1701 - (17%)
Similarity:	519/1701 - (30%)	Gaps:	601/1701 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1359 VGATVAAGASVLPNSRNR------STSSSG-ESSQMGLNSP----------QLGQLNLGFKTSV- 1405
            :|.|:.....::.::..|      :.|..| :..|...:||          .:..:..|:.|.|
Zfish    12 MGNTIQQPPQLIDSANIRQEDVYEAISDPGDDGGQQNFDSPLESGFSYPAEDVPVITNGYPTGVG 76

  Fly  1406 -----TATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIPSPTPTQM 1465
                 ...:|.:..|....|..|...:..::|..:...:||.          |.|....| .|.:
Zfish    77 TYEQQAKFALYSQFPNGSANGYGAIRNYGDHSLLLGEGTVLR----------PPVVQEKP-QTHI 130

  Fly  1466 QSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALP-TPMLTPMLSPQLPKPAQQQAHVVLPQ- 1528
            ..|:...|.||         ...|...|.||.....| .|.|.|......|.||......|||.
Zfish   131 SPPSHSHHHQQ---------PHHPHHHHHQQQQQHHPHNPPLLPHHHHHHPPPASHLMPQVLPPP 186

  Fly  1529 -----SQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVAQ--- 1585
                 .....||..|:|..| .|:.         ||:.|.....|   ::..||:.:..:.:
Zfish   187 PPLLLPSSPPLLSPQESTIS-NPIG---------QPVNTIITTTP---KKTSSPEIKLKIIKTYQ 238

  Fly  1586 ------QQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQ 1644
                  :..:.|...|:....:..::|.:|..::.:...|.    |.|  .|          ::.
Zfish   239 NGRELFESSLCGDLLQEFQAGEDSRRQHEQKKEKRKKRGSR----HGA--GH----------EES 287

  Fly  1645 SQPQQQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYP-QSPQRQQKPQPVQ-HQPQIVISTGAQ 1707
            .||.:.::......||  .||...:|:..::.|||... :||:.:.|.|.|: |.|.::.|||..
Zfish   288 QQPSKVEEERSVVVHN--PVQTTESQVAFREEQQPQSSLKSPKAELKEQKVEKHCPSVITSTGTS 350

  Fly  1708 ---AIPATMPTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKH----PQQQQQQQQQPVTP 1765
               .|...:..|:.:.......|.|:....|..:.:..|.|:...:.    |::....:::.|.
Zfish   351 QEYEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRINTRGCKEYHVQFFGSVPERAWIHEKRTVV- 414

  Fly  1766 VSAATAPAATPSSSESKEDDVSASS---TTTPTTRTPAKDKPKQSREDRKLEAIL---RAIEKME 1824
                       ..||::.|::.|.:   :|.||.:.... ||:..:|..:.|..:   .|..:|.
Zfish   415 -----------YKSENQFDELQAETLRKSTNPTEKQKLL-KPQSQKERAQWEVGVGHAEAALQMT 467

  Fly  1825 KQEARGKKDT----RQSSGGKRQASNSPA-SPNKRNSSNSISEDVETPTST-NSAAAAAQRRNKK 1883
            ::| |.:..|    .:..|...:.:.:|| :|:...::         ||.| .|..|.|:.|.::
Zfish   468 REE-RNENYTFIYIDKEPGADAETAAAPAPAPDSAPTA---------PTDTVTSPKATAKNRPER 522

  Fly  1884 KRKVSRSLNNNTNGLGSGGGS------NNKRRKSIVVESDGESHALTNSESEDQGQHPQSHHSGS 1942
            |::.||         ||.|..      ..:.|:...:.|.||:
Zfish   523 KQRRSR---------GSAGAKEEPIPRRQQPRRQCSMNSVGET---------------------- 556

  Fly  1943 EDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAMGPLQQQPAPASASPS 2007
                           ||||:. :..:.|..  |.:|                  .:|||....||
Zfish   557 ---------------SSPNQG-EDAMEQEQ--PCSP------------------PKPAPRPKEPS 585

  Fly  2008 LAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGE-----------REQLQRQ 2061
            ....:.|...|..:|.|..|                  ..|.::|.|           :.:|.::
Zfish   586 PPPVRTPWRTAAARKLLPLS------------------ITMKKLNVEIIKCDWQLPKQKVELPKK 632

  Fly  2062 PQGESLPAPALLKVEQFIHQAESTTAVPAREQLHLP--------LQNNSSVKKRWLRQAI----- 2113
            .:.|..|:..:...|...::||:.|.....|:...|        .....|.:::..|:::
Zfish   633 TESEERPSSRVKSPEGSSNKAEAETCSSEEERAASPSGWSDQEHTSAEQSTERKQQRRSVRSRSE 697

  Fly  2114 SEETT-PVDELQQSQNQSVTA------TPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESD 2171
            ||::. ||.:.:..:.|:.||      |.|.:....:|....    |||||
Zfish   698 SEKSVEPVPKKKVKKEQAETAPQMDFKTGSQKGASEISDSCK----PLKKR-------------- 744

  Fly  2172 ETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDT 2236
                            :.|.|::::....:....|.|...|..|..|..:  ..|:...::.:.:
Zfish   745 ----------------SRASTDVEMASSLYRDTSDSDSRGLNDPQTGFGK--RSDSPATVDADGS 791

  Fly  2237 SAAADDVKIDVEREES-------QACDKF-EEMVKVKREEEEQREKEIKQLQERQEHEQPKVEPA 2293
            .|.:.|..:..:...|       ..|:.| :.:|..:.:.......|.......:|.|
Zfish   792 DAQSVDSSLSRQGGSSSKKDTVCHVCETFGDSLVSCEGDCNRLFHPECMGSNSGKESE------- 849

  Fly  2294 PVEPKLENTVAKAEPKVEPSQEIVSKKEP------TKVEPKP----------GESLLRSTATVTA 2342
                    ||.         ||..:...|      |:.:.|.          .|:.:|. .|.:|
Zfish   850 --------TVC---------QECKTGSHPCFSCKVTEGDMKRCSVNGCGRYYHETCVRK-YTGSA 896

  Fly  2343 TPTAAT-----IAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAPVA------TVPPVS 2396
            :.|...     ..||..||              .|..:..|.::...:..|||      .|...|
Zfish   897 SDTKGLRCPQHSCATCCLD--------------RDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGS 947

  Fly  2397 V---PPIPAASNATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRNKKA 2458
            |   |.|...||.::|......::.:.........:.|..||..:.:||.:.....||.:.:.:|
Zfish   948 VLITPHIIICSNHSSSRKNGHFSSPVNVGWCFICARGLLVHDHTDTILSSYTFKSHYLLTESNRA 1012

  Fly  2459 ----TAALTSASPSQKSNSSSGG----------------------SGT----ESKKSSK------ 2487
                ...:.|:|.:.|.|...||                      .||    |.|...|
Zfish  1013 ELMKLPMIPSSSSATKKNIGKGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQI 1077

  Fly  2488 -----------------------------------------------------------DKD--- 2490
                                                                       ||:
Zfish  1078 VWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFPYVESDKNFAE 1142

  Fly  2491 -------------EKRDKEKQLKKSKKEKKKSKDKEKQ-----------------KAAVNVNSTS 2525
                         |:..|..|..|:::|.|::.::|:.                 |..::|...|
Zfish  1143 GQVGINKTFKKALEEAAKRFQELKAQRETKEALEQERNSRRPPPYKLIKSNKPFGKVQLHVADLS 1207

  Fly  2526 QIVDTKKKTT--QPSKPDSKS-------SIAPVLVP---------------PSLPVATANG---- 2562
            :|.....|.|  :|...||:.       ...|.:.|               |...|....|
Zfish  1208 EIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWG 1272

  Fly  2563 -KTKHTAYNN----------VDQQQQQQMRRRTMSMCIT-----PVTPTPVVTPSPLHGTPPSTK 2611
             |||......          :|.::.:|..|......:|     .:|...|:...|        |
Zfish  1273 LKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGP--------K 1329

  Fly  2612 KRQTNFEQELTKPNSQILSSSILLNSSKGLGL----PLAAPTVVSVPTAVQQQQHRKENNHQEAT 2672
            ...:.|......||.:  :....:|....:||    .::|.|.::.             |:
Zfish  1330 GNLSRFMNHSCSPNCE--TQKWTVNGDVRIGLFTLCDISADTELTF-------------NY---- 1375

  Fly  2673 PASGGPMSLAAAIASGKLNAISRRRESM-CGSRQQQALIA----AALKKEKKEK--------KKS 2724
                            .|:.:...|.|. |||......:.    :|:..|::||        ||.
Zfish  1376 ----------------NLDCLGNGRTSCHCGSENCSGFLGVKPKSAVVMEREEKVRNAKLKPKKR 1424

  Fly  2725 KKKDREKQKHD 2735
            |.|...||.|:
Zfish  1425 KLKTESKQTHE 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614
nsd3	XP_005155379.1	PWWP	351..468	CDD:321985	22/129 (17%)
		PHD1_NSD3	813..856	CDD:277119	10/66 (15%)
		PHD_SF	861..907	CDD:328929	8/46 (17%)
		PHD3_NSD3	908..960	CDD:277125	15/65 (23%)
		PHD4_NSD3	1033..1066	CDD:277128	4/32 (13%)
		WHSC1_related	1072..1165	CDD:99899	5/92 (5%)
		AWS	1208..1258	CDD:197795	8/49 (16%)
		SET	1259..1382	CDD:214614	24/165 (15%)
		PHD5_NSD3	1437..1479	CDD:277131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030