Protein Alignment Nprl3 and NPRL3

DIOPT Version :10

• Sequence 1: NP_648680.2
• Gene: Nprl3 / 39550
• FlyBaseID: FBgn0036397
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001070818.1
• Gene: NPRL3 / 8131
• HGNCID: 14124
• Length: 569
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 235/633 - (37%)
• Similarity: 340/633 - (53%)
• Gaps: 100/633 - (15%)

  Fly     1 METNVNPLAVILVYFDSKGDRLLYRYPYQTLGQTEVANDEQRKSRKRNPYAVANTDDLLQTPTHL 65
            |..|.:|::||||...|:|::||:|||:|. .|...|:   :.|:.|:.||.:||.|      |
Human     1 MRDNTSPISVILVSSGSRGNKLLFRYPFQR-SQEHPAS---QTSKPRSRYAASNTGD------H- 54

  Fly    66 GAAKSQGQLQGFADEVLSALFAVKPQLCNQKFELKLNDVRFVSHPTLIPQ---KEQRSGPMAKQQ 127
              |..|.....|:|.:|:.:.|.|.::|.||||||:::||||.||||:..   :..::.|..|::
Human    55 --ADEQDGDSRFSDVILATILATKSEMCGQKFELKIDNVRFVGHPTLLQHALGQISKTDPSPKRE 117

  Fly   128 ----MLINIVFALHAQASYSIVKCYHELSKRLGLALKFEEQRSGYLTEQTAQMARTHDEQQ---- 184
                :|.|:||||.|.|..|::.|.|.||:|:...|:.||:|..|||.:...:....||..
Human   118 APTMILFNVVFALRANADPSVINCLHNLSRRIATVLQHEERRCQYLTREAKLILALQDEVSAMAD 182

  Fly   185 -----QQPLERTLELIAERCSLAQALRSIFHDLCTTGLLSTSLNHNLTLCFCLPAKAHQLHKKGS 244
                 |.|...    |..:|.||:.|:..:..|||:|::...:|..|.:.||||.|.|  :...|
Human   183 GNEGPQSPFHH----ILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPHKIH--YAASS 241

  Fly   245 MVDPETIDRCLRALKPYHGMLLLVDFAELL-----DCVPPTGARMLWQLVDVYDPLISLQSMSSN 304
            ::.||.|:|.|:|::|||.:|||.|...||     ||.|     .|.:::.....:.:||.::.:
Human   242 LIPPEAIERSLKAIRPYHALLLLSDEKSLLGELPIDCSP-----ALVRVIKTTSAVKNLQQLAQD 301

  Fly   305 ADLSIEHVYKLVSHLVYWAKATIIYPLCETNVYVIAPDAPLHTKSHLVEKFSARFAGMSLFEVIS 369
            |||::..|::|.:|||||.||.|||||||.|||:::|:|.:...|.|.|:||.:|....|..|::
Human   302 ADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPNASVCLYSPLAEQFSHQFPSHDLPSVLA 366

  Fly   370 DFSLPTSIGHLTTPLQQPARQGILAQMVIWMLQHHLLMQLHTYVQFM--PSEDEFGDSASCSNHL 432
            .||||.|:.....||....::..|.|||:||||..||:||||||..|  |||:|
Human   367 KFSLPVSLSEFRNPLAPAVQETQLIQMVVWMLQRRLLIQLHTYVCLMASPSEEE----------- 420

  Fly   433 RDAISDEEGDQEPDADELHGSMLSMSSHPLPVP-AVLVGGHRREASEDHSSLASDNIAVQPSSSH 496
                      ..|..|:              || ...|||.         ||::.|.....|.:.
Human   421 ----------PRPREDD--------------VPFTARVGGR---------SLSTPNALSFGSPTS 452

  Fly   497 KSNFSITASMSTDNCD-----SLDSMEDEQKLKELLQVFSDADRAAIRRIPASANVDDLSLLVKL 556
            ..:.::| |.|.||..     |.||..:::..:.||...|:.:||||..:||:.|.:||.:..:|
Human   453 SDDMTLT-SPSMDNSSAELLPSGDSPLNQRMTENLLASLSEHERAAILSVPAAQNPEDLRMFARL 516

  Fly   557 YQMGYFKSEHHLEEIMYFENLRRSQLLQLLDKFRDVLIIYETEDPAIA 604
              :.||:..||||||||.||.||||||.|.||||.||::...|||.||
Human   517 --LHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDPVIA 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nprl3	NP_648680.2	NPR3	76..413	CDD:451662	139/357 (39%)
NPRL3	NP_001070818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..60		14/45 (31%)
		NPR3	64..416	CDD:451662	142/362 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..477		22/105 (21%)