DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nprl3 and nprl3

DIOPT Version :9

Sequence 1:	NP_001261818.1	Gene:	Nprl3 / 39550	FlyBaseID:	FBgn0036397	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	XP_021326650.1	Gene:	nprl3 / 564989	ZFINID:	ZDB-GENE-030131-1348	Length:	614	Species:	Danio rerio

Alignment Length:	636	Identity:	235/636 - (36%)
Similarity:	351/636 - (55%)	Gaps:	97/636 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NPLAVILVYFDSKGDRLLYRYPYQTLGQTEVANDEQRKSRKRNPYAVANTDDLLQTPTHLGAAKS 70
            :|::||||...|:|::||:|||:|...:    |.....|::|:||.:..:.|  .|....|.::.
Zfish    32 SPISVILVSSGSRGNKLLFRYPFQRASE----NTSSATSKQRSPYVLNTSGD--STEDQDGDSRE 90

  Fly    71 QGQL------QGFADEVLSALFAVKPQLCNQKFELKLNDVRFVSHPTLI--PQKEQ--RSGPMAK 125
            |..|      .||:|.:|:.:.|.|..:|.:|||||:::||||.||||:  |...|  ::.|..|
Zfish    91 QSPLTDEQLVSGFSDIILATILATKSDMCGKKFELKIDNVRFVGHPTLLQPPHTIQASKTDPSPK 155

  Fly   126 QQM----LINIVFALHAQASYSIVKCYHELSKRLGLALKFEEQRSGYLTEQTAQMARTHDE---- 182
            :::    |.::||||.|.|..|::.|.|.||:|:.:||:.||:|..|||.:...|....||
Zfish   156 RELPTMILFSVVFALRANADASVISCMHNLSRRIAIALQHEERRCQYLTREAKLMLVMQDEVTTI 220

  Fly   183 -----QQQQPLERTLELIAERCSLAQALRSIFHDLCTTGLLSTSLNHNLTLCFCLPAKAHQLHKK 242
                 ..|.|..:    |..:|.||:.|:..:..|||||::...:|:.|.:.||||   |::|:.
Zfish   221 TDSDGSPQSPFRQ----ILPKCKLARDLKEAYDSLCTTGVVRLHINNWLEVSFCLP---HKIHRV 278

  Fly   243 GSMVDP-ETIDRCLRALKPYHGMLLL----VDFAEL-LDCVPPTGARMLWQLVDVYDPLISLQSM 301
            |....| |.::|.|:|::|||.:|||    |..|:| |||.|     .|.:|:.....:.:||.:
Zfish   279 GGKHIPLEALERSLKAIRPYHALLLLENEKVLLAQLPLDCSP-----ALVRLIKTCSAVKNLQQL 338

  Fly   302 SSNADLSIEHVYKLVSHLVYWAKATIIYPLCETNVYVIAPDAPL-----HTKSHLVEKFSARFAG 361
            :.:|||::..::::.:|||||.||.|||||||.|||:::|.|.:     .:.|.|.|.|:.:|.|
Zfish   339 AQDADLALLQIFQIAAHLVYWGKAIIIYPLCENNVYMLSPHANICISSPSSYSPLAEHFAVQFPG 403

  Fly   362 MSLFEVISDFSLPTSIGHLTTPLQQPARQGILAQMVIWMLQHHLLMQLHTYVQFM--PSEDEFGD 424
            ..|..:::.||||.|:.....||..|..:..|.|||:|||||.||.||||||..:  |:|:|.|
Zfish   404 HDLPSMLAKFSLPVSLSEFRNPLDAPVHEAHLIQMVVWMLQHRLLFQLHTYVCLLVPPNEEEPG- 467

  Fly   425 SASCSNHLRDAISDEEGDQEPDADELHGSMLSMSSHPLPVPAVLVGGHRREASEDHSSLASDNIA 489
                   |||       ::.|....:.|..||       .|:.|..|         |..:||::.
Zfish   468 -------LRD-------EELPIVTRVTGRSLS-------TPSALSFG---------SPTSSDDMT 502

  Fly   490 V-QPSSSHKSNFSITASMSTDNCDSLDSMEDEQKLKELLQVFSDADRAAIRRIPASANVDDLSLL 553
            : .||..:.|     |.:.|..    ||..:::..:.||...::.:|.||.|:||:.|.:||.|.
Zfish   503 LTSPSMDNSS-----AELQTGG----DSPLNKRMTETLLASLTEHERQAILRVPAAQNPEDLRLF 558

  Fly   554 VKLYQMGYFKSEHHLEEIMYFENLRRSQLLQLLDKFRDVLIIYETEDPAIA 604
            .:|  :.||:..||||||||.||||||||..|.||||.||:|...|||.|:
Zfish   559 ARL--LHYFRGHHHLEEIMYNENLRRSQLKTLFDKFRSVLVITNHEDPIIS 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nprl3	NP_001261818.1	NPR3	76..413	CDD:305178	143/364 (39%)
nprl3	XP_021326650.1	NPR3	102..461	CDD:329240	145/370 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581398
Domainoid	1	1.000	210	1.000	Domainoid score	I2781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8091
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2185
OMA	1	1.010	-	-		QHG53225
OrthoDB	1	1.010	-	-		D260717at33208
OrthoFinder	1	1.000	-	-		FOG0006449
OrthoInspector	1	1.000	-	-		oto41216
orthoMCL	1	0.900	-	-		OOG6_104131
Panther	1	1.100	-	-	LDO	PTHR13153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R838
SonicParanoid	1	1.000	-	-		X7263
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900