Protein Alignment Nprl3 and Nprl3

DIOPT Version :10

• Sequence 1: NP_648680.2
• Gene: Nprl3 / 39550
• FlyBaseID: FBgn0036397
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_001381164.1
• Gene: Nprl3 / 360505
• RGDID: 1308665
• Length: 582
• Species: Rattus norvegicus
• Alignment Length: 638
• Identity: 234/638 - (36%)
• Similarity: 344/638 - (53%)
• Gaps: 97/638 - (15%)

  Fly     1 METNVNPLAVILVYFDSKGDRLLYRYPYQTLGQTEVANDEQRKSRKRNPYAVANTDDLLQ----- 60
            |..|.:|::||||...|:|::||:|||:|...:...:...:.:||    |||.||.:.:.
  Rat     1 MGDNTSPISVILVSSGSRGNKLLFRYPFQRSQEHPASQTNKPRSR----YAVNNTGEHVDDQDGD 61

  Fly    61 -----TPTHLGAAKSQGQLQGFADEVLSALFAVKPQLCNQKFELKLNDVRFVSHPTLIPQ---KE 117
                 .||      .:..:.||:|.:|:.:.|.|.::|.||||||:::||||.||||:..   :.
  Rat    62 SSKPCPPT------DEQLVAGFSDAILATILATKSEMCGQKFELKIDNVRFVGHPTLLQHALGQV 120

  Fly   118 QRSGPMAKQQ----MLINIVFALHAQASYSIVKCYHELSKRLGLALKFEEQRSGYLTEQTAQMAR 178
            .::.|..|::    :|.|:||||.|.|..|::.|.|.||:|:...|:.||:|..|||.:...:..
  Rat   121 SKTDPSPKREAPTMILFNVVFALRANADPSVINCLHTLSRRIATVLQHEERRCQYLTREAKLILA 185

  Fly   179 THDEQQ---------QQPLERTLELIAERCSLAQALRSIFHDLCTTGLLSTSLNHNLTLCFCLPA 234
            ..||..         |.|...    |..:|.||:.|:..:..|||:|::...:|..|.:.||||.
  Rat   186 LQDEVSAMADANEGPQSPFHH----ILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPH 246

  Fly   235 KAHQLHKKGSMVDPETIDRCLRALKPYHGMLLLVDFAELLDCVPPTGARMLWQLVDVYDPLISLQ 299
            |.|  :...|::.||.|:|.|:|::|||.:|||.|...||..:|...:..|.:::.....:.:||
  Rat   247 KIH--YAASSLIPPEAIERSLKAIRPYHALLLLSDEKSLLSELPIDCSPALVRVIKTTSAVKNLQ 309

  Fly   300 SMSSNADLSIEHVYKLVSHLVYWAKATIIYPLCETNVYVIAPDAPLHTKSHLVEKFSARFAGMSL 364
            .::.:|||::..|::|.:|||||.||.|||||||.||||::|:|.:...|.|.|:||.:|....|
  Rat   310 QLAQDADLALLQVFQLAAHLVYWGKAVIIYPLCENNVYVLSPNASVCLYSPLAEQFSRQFPSHDL 374

  Fly   365 FEVISDFSLPTSIGHLTTPLQQPARQGILAQMVIWMLQHHLLMQLHTYVQFM--PSEDEFGDSAS 427
            ..|::.||||.|:....:||..||::..|.|||:||||..||:||||||..|  |||:|
  Rat   375 PSVLAKFSLPVSLSEFRSPLAPPAQETQLIQMVVWMLQRRLLIQLHTYVCLMASPSEEE------ 433

  Fly   428 CSNHLRDAISDEEGDQEPDADELHGSMLSMSSHPLPVP-AVLVGGHRREASEDHSSLASDNIAVQ 491
                           ..|..|:              || ...|||.         ||::.|....
  Rat   434 ---------------PRPREDD--------------VPFTARVGGR---------SLSTPNALSF 460

  Fly   492 PSSSHKSNFSITASMSTDNCD-----SLDSMEDEQKLKELLQVFSDADRAAIRRIPASANVDDLS 551
            .|.:...:.::| |.|.||..     |.||..:::..:.||...|:.:||||..:||:.|.:||.
  Rat   461 GSPTSSDDMTLT-SPSMDNSSAELLPSGDSPLNKRMTENLLASLSEHERAAILNVPAAQNPEDLR 524

  Fly   552 LLVKLYQMGYFKSEHHLEEIMYFENLRRSQLLQLLDKFRDVLIIYETEDPAIA 604
            :..:|  :.||:..||||||||.||.||||||.|.||||.||::...|||.||
  Rat   525 MFARL--LHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDPVIA 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nprl3	NP_648680.2	NPR3	76..413	CDD:451662	141/352 (40%)
Nprl3	NP_001381164.1	NPR3	76..429	CDD:451662	148/370 (40%)