Protein Alignment Nprl3 and nprl-3

DIOPT Version :9

• Sequence 1: NP_001261818.1
• Gene: Nprl3 / 39550
• FlyBaseID: FBgn0036397
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_501396.1
• Gene: nprl-3 / 185331
• WormBaseID: WBGene00018072
• Length: 511
• Species: Caenorhabditis elegans
• Alignment Length: 615
• Identity: 149/615 - (24%)
• Similarity: 253/615 - (41%)
• Gaps: 146/615 - (23%)

  Fly     9 AVILVYFDSKGDRLLYRYPYQTLGQTEVANDEQRKSRKRNP-YAVANTDDLLQTPTH-LGAAKSQ 71
            ||:.......|::::..||::.......:.|.|..|  .|| ..|......::.|:: .|...::
 Worm    16 AVMCFLTGQSGEKIVSIYPHRKPATKAPSKDPQPSS--SNPGQCVKPVLTSVKDPSYGFGRVDTE 78

  Fly    72 GQLQ-GFADEVLSALFAVKPQLCNQKFELKLNDVRFVSHPTLIPQKEQRSGPMAKQQMLINIVFA 135
            ..:. |    :|:.:|..:...||..|::|:|:.|||::    |:..:..|.....|  |:||||
 Worm    79 FDMSLG----MLAYVFKTQEIACNDGFDMKINNQRFVAY----PKTWKARGESTNYQ--ISIVFA 133

  Fly   136 LHAQASYSIVKCYHELSKRLGLALKFEEQRSGYLTEQTAQMARTHDEQQQQPLERTLELIAERCS 200
            |...........|..||.::.::|...:...|:|..:........:..:..|||.    .|:...
 Worm   134 LKNGCEQHTASAYQTLSNKIAVSLVMLQNYFGFLEREDKWADNAEEPNKDHPLEE----FAKTSF 194

  Fly   201 LAQALRSIFHDLCTTGLLSTSLNHNLTLCFCLPAKAHQLHK-----KGSMVDPETIDRCLRALKP 260
            :.|.|..:|.::...|.:...|.:.:.|.||  .:||.|.|     ||.    :.||..:|.:||
 Worm   195 IVQPLAEMFEEVRNRGNIHKYLINFVELGFC--DEAHALTKLNVVPKGR----QEIDEIVRKMKP 253

  Fly   261 YHGMLLLVDFAELLDCVPPTGARMLWQLVDVYDPLISLQSMSSNADLSIEHVYKLVSHLVYWAKA 325
            |||:|||.|.....|..|     ::.:|:....|..|:..||:.:.:.|..|:.::.||:.|.:|
 Worm   254 YHGILLLEDVWPTPDANP-----IVAKLLSHCSPDRSILDMSTASGIPIFEVFMIIRHLLQWTRA 313

  Fly   326 TIIYPLCETNVYVIAPD-APLHTKSHLVEKFSARFAG-MSLFEVISDFSLPTSIG---HLTTPLQ 385
            .:|||||.||:|..|.. .||   ..:.|||:|:|.. :.|...::.|:.|.::.   ....||.
 Worm   314 ILIYPLCNTNIYTSATSPQPL---DKMAEKFTAQFGNTIHLAAGLAHFNPPKTLDTFIRKNLPLH 375

  Fly   386 QPARQGILAQMVIWMLQHHLLMQLHTY--------VQFMPSEDEFGDSASCSNHLRDAISDEEGD 442
            :   ||:.|::|:.:|:|.:|||||.:        :..:|...|
 Worm   376 E---QGVRAKLVVALLRHQMLMQLHQFYYILKPYSIAILPEPKE--------------------- 416

  Fly   443 QEPDADELHGSMLSMSSHPLPVPAVLVGGHRREASE--DHSSLASDNIAVQPSSSHKSNFSITAS 505
                                |.||        |.::  :.|:|.:|                ...
 Worm   417 --------------------PCPA--------EFTKIIEESTLPND----------------VKG 437

  Fly   506 MSTDNCDSLDSMEDEQKLKELLQVFSDADRAAIRRIPASANVDDLSLLVKLYQMGYFKSEHHLEE 570
            :..|.|            .|:|:..|   .|:::|        .|||.||:..|  ....|||||
 Worm   438 VVADIC------------AEMLETTS---YASVKR--------TLSLFVKVAPM--MDGNHHLEE 477

  Fly   571 IMYFENLRRSQLLQLLDKFRDVLIIYETED 600
            |.|..||.|:::..:...|:.|:..:...|
 Worm   478 IKYKNNLDRTEIEGVFVSFKLVIATFRRPD 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nprl3	NP_001261818.1	NPR3	76..413	CDD:305178	101/354 (29%)
nprl-3	NP_501396.1	NPR3	<253..402	CDD:305178	53/159 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3830
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8091
Inparanoid	1	1.050	164	1.000	Inparanoid score	I2824
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53225
OrthoDB	1	1.010	-	-		D260717at33208
OrthoFinder	1	1.000	-	-		FOG0006449
OrthoInspector	1	1.000	-	-		oto19554
orthoMCL	1	0.900	-	-		OOG6_104131
Panther	1	1.100	-	-	LDO	PTHR13153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R838
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.840