DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17359 and znf180

DIOPT Version :9

Sequence 1:	NP_648679.1	Gene:	CG17359 / 39549	FlyBaseID:	FBgn0036396	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001072533.1	Gene:	znf180 / 779988	XenbaseID:	XB-GENE-5829966	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	303	Identity:	86/303 - (28%)
Similarity:	128/303 - (42%)	Gaps:	59/303 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 EC-SGCSVHKEDGMPQFICVECAEAVRNAYRLRRQCRKSHQYFEQLRLMMKELDDIEYCLNIGDN 107
            || :|.:.|..:  ..:.|.||.:....:..|.|..|                      ::||:.
Frog   177 ECMAGLNSHTTE--KYYTCTECGKGFNRSSHLLRHKR----------------------IHIGER 217

  Fly   108 IEPQMPVSVMEAGKTPETSEPLLVELVQVKYMPPEPKPISSPLPDNNEHKLAQSYSPAKTPHNKS 172
                 |....:.||:...|..|::.    |......||.:  ..|..:..:.:.:   ...|.:|
Frog   218 -----PYFCGKCGKSFIDSSQLVIH----KRTHTGEKPYA--CSDCEKSFICKLH---LVRHQRS 268

  Fly   173 KRRARSYSDN-------DSWSPDSELEHEDDDKIWNASKRGKP----------KRV---PGPYRC 217
            ....|.|..:       .|.:..:.|.....:|.::.::.||.          :|:   .|||.|
Frog   269 HTGERPYVCSKCGKGFAQSSNLLTHLRTHTGEKPYSCAQCGKSFIRRSHVIRHQRIHTGEGPYGC 333

  Fly   218 KLCTQSFTQKQNLEIHMRIHTGERPYKCSLCPRSFAQKGNLQSHTRCHTGERPFGCPNCPKRFRQ 282
            ..|.:|||:...|..|.|.||||:||.|:.||:||..|..|.:|.|.||||||:.|.:|.|.|..
Frog   334 TECGKSFTESSALLKHQRTHTGEKPYACTQCPKSFMDKSALANHQRTHTGERPYPCRDCGKSFSH 398

  Fly   283 VGQLQVHTRTHTGEQPFKCSKCQQSFKQLNGLQKHMSAHTRGK 325
            ...|..|.|.||||:|:.|.||::||.|.:.|..|...||..|
Frog   399 SSALVKHQRIHTGEKPYACGKCEKSFSQTSALVNHQRTHTGEK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17359	NP_648679.1	zf-AD	6..88	CDD:285071	10/44 (23%)
		zf-C2H2	215..237	CDD:278523	9/21 (43%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		zf-H2C2_2	229..254	CDD:290200	14/24 (58%)
		C2H2 Zn finger	245..265	CDD:275368	9/19 (47%)
		zf-H2C2_2	257..282	CDD:290200	13/24 (54%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..310	CDD:290200	13/23 (57%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
znf180	NP_001072533.1	KRAB	13..54	CDD:307490
		COG5048	189..465	CDD:227381	82/289 (28%)
		C2H2 Zn finger	193..213	CDD:275368	6/41 (15%)
		C2H2 Zn finger	221..241	CDD:275368	5/23 (22%)
		C2H2 Zn finger	249..269	CDD:275368	2/22 (9%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	305..325	CDD:275368	3/19 (16%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		C2H2 Zn finger	361..381	CDD:275368	9/19 (47%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		C2H2 Zn finger	445..465	CDD:275368
		zf-H2C2_2	457..482	CDD:316026
		C2H2 Zn finger	473..493	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910