DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG17359 and ZNF146

DIOPT Version :9

Sequence 1:NP_648679.1 Gene:CG17359 / 39549 FlyBaseID:FBgn0036396 Length:339 Species:Drosophila melanogaster
Sequence 2:NP_001093108.1 Gene:ZNF146 / 7705 HGNCID:12931 Length:292 Species:Homo sapiens


Alignment Length:296 Identity:77/296 - (26%)
Similarity:133/296 - (44%) Gaps:44/296 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 GMPQFICVECAEAVRNAYRLRR-----------QCRKSHQYFEQLRLMMKELDDIEYCLNIGDNI 108
            |...|.|..|.:...:...|..           :|.:..:.|.|.:.::|..:     .:.|:.:
Human    12 GENPFACKVCGKVFSHKSNLTEHEHFHTREKPFECNECGKAFSQKQYVIKHQN-----THTGEKL 71

  Fly   109 EPQMPVSVMEAGKTPETSEPLLV-ELVQVKYMPPEPKPISSPLPDNNEHKLAQSYSPAKTPHNKS 172
                 ....|.||:....|.||. :.:.....|.|.|.........:.....|.....:.|. ..
Human    72 -----FECNECGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPF-VC 130

  Fly   173 KRRARSYSDNDSWSPDSELEHED---DDKIWNASKRG----------KPKRV---PGPYRCKLCT 221
            |...:::|...:.:     |||.   .:|.:..|:.|          |.:.:   ..||.|..|.
Human   131 KECGKTFSGKSNLT-----EHEKIHIGEKPFKCSECGTAFGQKKYLIKHQNIHTGEKPYECNECG 190

  Fly   222 QSFTQKQNLEIHMRIHTGERPYKCSLCPRSFAQKGNLQSHTRCHTGERPFGCPNCPKRFRQVGQL 286
            ::|:|:.:|.:|:|||:|::||:|::|.::|:|..:|..|.|.||||:|:||..|.|.|.|...|
Human   191 KAFSQRTSLIVHVRIHSGDKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTL 255

  Fly   287 QVHTRTHTGEQPFKCSKCQQSFKQLNGLQKHMSAHT 322
            .:|.|.|||::|::||:|.::|.|.:...:|...||
Human   256 ALHLRIHTGKKPYQCSECGKAFSQKSHHIRHQKIHT 291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17359NP_648679.1 zf-AD 6..88 CDD:285071 7/43 (16%)
zf-C2H2 215..237 CDD:278523 8/21 (38%)
C2H2 Zn finger 217..237 CDD:275368 7/19 (37%)
zf-H2C2_2 229..254 CDD:290200 11/24 (46%)
C2H2 Zn finger 245..265 CDD:275368 7/19 (37%)
zf-H2C2_2 257..282 CDD:290200 13/24 (54%)
C2H2 Zn finger 273..293 CDD:275368 8/19 (42%)
zf-H2C2_2 286..310 CDD:290200 11/23 (48%)
C2H2 Zn finger 301..321 CDD:275368 6/19 (32%)
ZNF146NP_001093108.1 COG5048 <1..260 CDD:227381 64/263 (24%)
C2H2 Zn finger 18..38 CDD:275368 3/19 (16%)
C2H2 Zn finger 46..66 CDD:275368 4/24 (17%)
C2H2 Zn finger 74..94 CDD:275368 6/19 (32%)
C2H2 Zn finger 102..122 CDD:275368 2/19 (11%)
C2H2 Zn finger 130..150 CDD:275368 5/24 (21%)
C2H2 Zn finger 158..178 CDD:275368 3/19 (16%)
C2H2 Zn finger 186..206 CDD:275368 7/19 (37%)
Interaction with TERF2IP. /evidence=ECO:0000269|PubMed:15838871 212..292 34/80 (43%)
C2H2 Zn finger 214..234 CDD:275368 7/19 (37%)
C2H2 Zn finger 242..262 CDD:275368 8/19 (42%)
zf-H2C2_2 255..279 CDD:404364 11/23 (48%)
C2H2 Zn finger 270..290 CDD:275368 6/19 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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