DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG17359 and ZNF70

DIOPT Version :9

Sequence 1:NP_648679.1 Gene:CG17359 / 39549 FlyBaseID:FBgn0036396 Length:339 Species:Drosophila melanogaster
Sequence 2:NP_068735.1 Gene:ZNF70 / 7621 HGNCID:13140 Length:446 Species:Homo sapiens


Alignment Length:341 Identity:99/341 - (29%)
Similarity:149/341 - (43%) Gaps:63/341 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DESD--------CLLDIYTEPYASSNRVQEQEPVLATMLR--ECSGCS-VHKEDGMPQFICVECA 65
            :|:|        |...:..:......|.|:.|....|.|:  :.|.|. :|.|:..|   | :||
Human    58 EENDDYEGNFSLCSSPVQHQSIPPGTRPQDDELFGQTFLQKSDLSMCQIIHSEEPSP---C-DCA 118

  Fly    66 EAVR-----NAYRLRRQ------CRKSHQYFEQLRLMMKELDDIEYCLNIGDNIEPQMPVSVMEA 119
            |..|     ||.....|      ||:..:.|.|...:::.|     .::.|:.     |....|.
Human   119 ETDRGDSGPNAPHRTPQPAKPYACRECGKAFSQSSHLLRHL-----VIHTGEK-----PYECCEC 173

  Fly   120 GKT-PETSEPLLVELVQVKYMPPEPKPISSPLPDNNEHKLAQSYSPAKTPHNKSKRRARSYSDND 183
            ||. .::|..|..:::.....|.|.:          |...|...|.|.|.|.|.....|.|...:
Human   174 GKAFSQSSHLLRHQIIHTGEKPYECR----------ECGKAFRQSSALTQHQKIHTGKRPYECRE 228

  Fly   184 ---SWSPDSEL-EHEDDDKIWNASKRGKPKRVPGPYRCKLCTQSFTQKQNLEIHMRIHTGERPYK 244
               .:|..|.| :||   :|....:         ||:||.|.:||.|...|..|.:|||.::|::
Human   229 CGKDFSRSSSLRKHE---RIHTGER---------PYQCKECGKSFNQSSGLSQHRKIHTLKKPHE 281

  Fly   245 CSLCPRSFAQKGNLQSHTRCHTGERPFGCPNCPKRFRQVGQLQVHTRTHTGEQPFKCSKCQQSFK 309
            |.||.::|..:.:|..|.|.|||::|:.|..|.|.|.|...|..|.:|||||:|:||.||.::|.
Human   282 CDLCGKAFCHRSHLIRHQRIHTGKKPYKCDECGKAFSQSSNLIEHRKTHTGEKPYKCQKCGKAFS 346

  Fly   310 QLNGLQKHMSAHTRGK 325
            |.:.|.:|...||..|
Human   347 QSSSLIEHQRIHTGEK 362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17359NP_648679.1 zf-AD 6..88 CDD:285071 24/97 (25%)
zf-C2H2 215..237 CDD:278523 9/21 (43%)
C2H2 Zn finger 217..237 CDD:275368 8/19 (42%)
zf-H2C2_2 229..254 CDD:290200 10/24 (42%)
C2H2 Zn finger 245..265 CDD:275368 7/19 (37%)
zf-H2C2_2 257..282 CDD:290200 11/24 (46%)
C2H2 Zn finger 273..293 CDD:275368 7/19 (37%)
zf-H2C2_2 286..310 CDD:290200 13/23 (57%)
C2H2 Zn finger 301..321 CDD:275368 7/19 (37%)
ZNF70NP_068735.1 C2H2 Zn finger 92..108 CDD:275368 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..138 9/27 (33%)
COG5048 138..442 CDD:227381 78/257 (30%)
C2H2 Zn finger 142..162 CDD:275368 5/24 (21%)
C2H2 Zn finger 170..190 CDD:275368 5/19 (26%)
C2H2 Zn finger 198..218 CDD:275368 7/29 (24%)
C2H2 Zn finger 226..246 CDD:275368 5/22 (23%)
C2H2 Zn finger 254..274 CDD:275368 8/19 (42%)
C2H2 Zn finger 282..302 CDD:275368 7/19 (37%)
C2H2 Zn finger 310..330 CDD:275368 7/19 (37%)
C2H2 Zn finger 338..358 CDD:275368 7/19 (37%)
C2H2 Zn finger 366..386 CDD:275368
C2H2 Zn finger 394..413 CDD:275368
C2H2 Zn finger 421..441 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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