DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17359 and ZNF793

DIOPT Version :9

Sequence 1:	NP_648679.1	Gene:	CG17359 / 39549	FlyBaseID:	FBgn0036396	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001013681.2	Gene:	ZNF793 / 390927	HGNCID:	33115	Length:	406	Species:	Homo sapiens

Alignment Length:	391	Identity:	103/391 - (26%)
Similarity:	148/391 - (37%)	Gaps:	116/391 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DCLLDIY----------TEPYASSNRVQEQEPVLATMLRECSGCSVHKEDGMPQFICVECAEAV- 68
            |.:|:.|          |:|.......||:.|.:..  ..|.||              .|.|.:
Human    35 DVMLETYSNLVSVGYEGTKPDVILRLEQEEAPWIGE--AACPGC--------------HCWEDIW 83

  Fly    69 -RNAYRLRRQ----------------CRKSHQY--FEQLRLMMKEL-DDIEYCLN---IGDNIEP 110
             .|..|.|||                ..||.:|  |.::.|:..:| ..|:...|   .|.|:..
Human    84 RVNIQRKRRQDMLLRPGAAISKKTLPKEKSCEYNKFGKISLLSTDLFSSIQSPSNWNPCGKNLNH 148

  Fly   111 QMP---------------------VSVMEAGKTPE--------------TSEPLLVE-------- 132
            .:.                     :..:..|:.|.              |..|.|:.
Human   149 NLDLIGFKRNCAKKQDECYAYGKLLQRINHGRRPNGEKPRGCSHCEKAFTQNPALMYKPAVSDSL 213

  Fly   133 LVQVKYMPPEPKP-ISSPLPDNNEHKLAQSYSPAKTPHNKSKRRARSYSDND---SWSPDSEL-E 192
            |.:.|.:||..|| :.|      |...|..|......|.:|....:.|...|   ::|..|.| :
Human   214 LYKRKRVPPTEKPHVCS------ECGKAFCYKSEFIRHQRSHTGEKPYGCTDCGKAFSHKSTLIK 272

  Fly   193 HEDDDKIWNASKRGKPKRVPGPYRCKLCTQSFTQKQNLEIHMRIHTGERPYKCSLCPRSFAQKGN 257
            |:   :|....:         |:.|..|.::||||.:...|.|.||||||:.||.|.:||.:|..
Human   273 HQ---RIHTGVR---------PFECFFCGKAFTQKSHRTEHQRTHTGERPFVCSECGKSFGEKSY 325

  Fly   258 LQSHTRCHTGERPFGCPNCPKRFRQVGQLQVHTRTHTGEQPFKCSKCQQSFKQLNGLQKHMSAHT 322
            |..|.:.||||||:.|..|.|.|.|...|..|.||||||:|:.|::|.::|.|...|.:|...|.
Human   326 LNVHRKMHTGERPYRCRECGKSFSQKSCLNKHWRTHTGEKPYGCNECGKAFYQKPNLSRHQKIHA 390

  Fly   323 R 323
            |
Human   391 R 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17359	NP_648679.1	zf-AD	6..88	CDD:285071	22/102 (22%)
		zf-C2H2	215..237	CDD:278523	8/21 (38%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		zf-H2C2_2	229..254	CDD:290200	13/24 (54%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		zf-H2C2_2	257..282	CDD:290200	12/24 (50%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..310	CDD:290200	12/23 (52%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
ZNF793	NP_001013681.2	KRAB	8..68	CDD:214630	8/32 (25%)
		C2H2 Zn finger	190..221	CDD:275368	5/30 (17%)
		COG5048	<225..385	CDD:227381	63/177 (36%)
		C2H2 Zn finger	229..249	CDD:275368	5/25 (20%)
		C2H2 Zn finger	257..277	CDD:275368	5/22 (23%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		C2H2 Zn finger	341..361	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910