DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17359 and CG2202

DIOPT Version :9

Sequence 1:	NP_648679.1	Gene:	CG17359 / 39549	FlyBaseID:	FBgn0036396	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	130/705 - (18%)
Similarity:	180/705 - (25%)	Gaps:	387/705 - (54%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDISQMCRVCRDESDCLLDIYTE---PYASSNRVQEQEPVLATMLRECSGCSVHKEDGMPQFICV 62
            :|..::|||      ||.|:..|   .:..:....||:..||.:|.||:.....:.||||..:|.
  Fly    40 VDAERVCRV------CLKDVSLEGELHFIFNETPVEQDANLARILDECTLHQCERNDGMPPHMCS 98

  Fly    63 ECAEAVRNAYRLRRQCRKSH--------------------------------------------- 82
            .|.||.|||||.:|...:|:
  Fly    99 SCVEAARNAYRFKRHAERSYCSLVALLGRSPQLKARGAEAASQTDQVALLPCEMCHDQFLNSLEL 163

  Fly    83 ---------------------------------QYFEQLRLMMK--------------------- 93
                                             |:|..||.:..
  Fly   164 RLHRNQVHRTTKEATSAGTDGLPSEDFKCKFCPQHFPHLRQLRSHLARSHEQTARLQCAHCQRTF 228

  Fly    94 ---------------------------------------ELDDIEYCLNIGDNIEPQMPVSVMEA 119
                                                   ||...|..||..|| |.::.....:.
  Fly   229 SRRDHLLRHIRNQHRDVEEDLLRTWPPADENTMNSDGGDELVSAEVLLNEEDN-EDEVVGEAFQC 292

  Fly   120 GKTPETS---------------------EPLL----VEL-VQVKY-------------------- 138
            ...|.:|                     ||.|    |:| :|:|.
  Fly   293 NTNPISSNEDDGEEANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDR 357

  Fly   139 ----------------------------------------------------------------- 138

  Fly   358 TVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDSDLDD 422

  Fly   139 -------------------MPPEP----KPI--------------SSPLPDNN------------ 154
                               :..||    ||:              ..|.|||.
  Fly   423 DDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSRHC 487

  Fly   155 ---EHKLAQ-SYSPAKTPH--------------------NKS----------------KRRARSY 179
               .|||:. ...|...||                    ||.                :|...|.
  Fly   488 HLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSK 552

  Fly   180 SDNDSWSPDSEL-----EHE-------------------------------DDDKIWNASKRGKP 208
            .:.:...|.|||     ||.                               |:.....|..|...
  Fly   553 HNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHTDFLYACKTCDETFRERAQLREHE 617

  Fly   209 KRVPGP--YRCKLCTQSFTQKQNLEIHMRIHTGERPYKCSLCPRSFAQKGNLQSHTRCHTGERPF 271
            |...|.  :.|.:|..||.:...|.:|||.|.||:||||..|.::|.:..:|:.|.|.|||.:|.
  Fly   618 KTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYHTGTKPN 682

  Fly   272 GCPNCPKRFRQVGQLQVHTRTHTGEQPFKCSKCQQSFKQLNGLQKHMSAHTRGKR 326
            .|..|.|.|.:...|.:|.||||||:|:||.:|.:||.|.|.|:.|:..|| |:|
  Fly   683 LCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHT-GER 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17359	NP_648679.1	zf-AD	6..88	CDD:285071	31/162 (19%)
		zf-C2H2	215..237	CDD:278523	8/21 (38%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		zf-H2C2_2	229..254	CDD:290200	13/24 (54%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		zf-H2C2_2	257..282	CDD:290200	11/24 (46%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..310	CDD:290200	14/23 (61%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	29/81 (36%)
		C2H2 Zn finger	150..171	CDD:275368	0/20 (0%)
		C2H2 Zn finger	192..213	CDD:275370	4/20 (20%)
		C2H2 Zn finger	221..239	CDD:275370	0/17 (0%)
		COG5048	<443..730	CDD:227381	75/286 (26%)
		C2H2 Zn finger	476..496	CDD:275368	3/19 (16%)
		zf-H2C2_2	488..513	CDD:290200	6/24 (25%)
		C2H2 Zn finger	504..525	CDD:275368	2/20 (10%)
		C2H2 Zn finger	532..548	CDD:275368	0/15 (0%)
		C2H2 Zn finger	573..593	CDD:275368	0/19 (0%)
		C2H2 Zn finger	600..620	CDD:275368	4/19 (21%)
		zf-H2C2_2	613..637	CDD:290200	7/23 (30%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	12/22 (55%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		zf-C2H2	684..704	CDD:278523	7/19 (37%)
		zf-H2C2_2	696..721	CDD:290200	14/24 (58%)
		C2H2 Zn finger	712..732	CDD:275368	8/19 (42%)
		C2H2 Zn finger	739..755	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930