DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17359 and Zfp46

DIOPT Version :9

Sequence 1:	NP_648679.1	Gene:	CG17359 / 39549	FlyBaseID:	FBgn0036396	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001357580.1	Gene:	Zfp46 / 22704	MGIID:	99192	Length:	470	Species:	Mus musculus

Alignment Length:	306	Identity:	87/306 - (28%)
Similarity:	133/306 - (43%)	Gaps:	58/306 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LRECSGCSVHKE--DGMPQFICVECAEAVRNAYRLRRQCRKSHQYFEQLRLMMKELDDIEYCLNI 104
            |::.:...||||  .|:...||.:|.:|......|.|. :|:|                     .
Mouse   119 LQQVTDLLVHKEAHAGIRYHICSQCGKAFSQISDLNRH-QKTH---------------------T 161

  Fly   105 GDNIEPQMPVSVMEAGKTPETSEPLLVELVQVKYMPPEPKPISSPLPDNNE---------HKLA- 159
            ||.     |....|.||....|.    .|:|.:......:|.     |.||         |.:.
Mouse   162 GDR-----PYKCYECGKGFSRSS----HLIQHQRTHTGERPY-----DCNECGKSFGRSSHLIQH 212

  Fly   160 QSYSPAKTPHNKSK------RRARSYSDNDSWSPDSELEHEDDDKIWNASKR-GKPKRV---PGP 214
            |:....:.||..::      |.:.......:.|.:...|.|:..|.::.|.. .:.:|.   ..|
Mouse   213 QTIHTGEKPHKCTECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEKP 277

  Fly   215 YRCKLCTQSFTQKQNLEIHMRIHTGERPYKCSLCPRSFAQKGNLQSHTRCHTGERPFGCPNCPKR 279
            |.|..|.:.|:::.:|..|.|:|||||||||..|.::|:|..:|..|.|.||||:|:.|..|.:.
Mouse   278 YECHECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPYHCNECGEN 342

  Fly   280 FRQVGQLQVHTRTHTGEQPFKCSKCQQSFKQLNGLQKHMSAHTRGK 325
            |.::..|..|.||||||:|::|:.|.:||.:.:.|..|...||..|
Mouse   343 FSRISHLVQHQRTHTGEKPYECTACGKSFSRSSHLITHQKIHTGEK 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17359	NP_648679.1	zf-AD	6..88	CDD:285071	14/47 (30%)
		zf-C2H2	215..237	CDD:278523	7/21 (33%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		zf-H2C2_2	229..254	CDD:290200	14/24 (58%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	257..282	CDD:290200	11/24 (46%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		zf-H2C2_2	286..310	CDD:290200	13/23 (57%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
Zfp46	NP_001357580.1	KRAB	13..54	CDD:366587
		C2H2 Zn finger	140..160	CDD:275368	6/20 (30%)
		COG5048	163..>470	CDD:227381	72/240 (30%)
		C2H2 Zn finger	168..188	CDD:275368	6/23 (26%)
		C2H2 Zn finger	196..216	CDD:275368	4/19 (21%)
		C2H2 Zn finger	224..244	CDD:275368	1/19 (5%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368
		C2H2 Zn finger	420..440	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000