DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17359 and si:dkey-22h13.1

DIOPT Version :9

Sequence 1:	NP_648679.1	Gene:	CG17359 / 39549	FlyBaseID:	FBgn0036396	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	XP_021331234.1	Gene:	si:dkey-22h13.1 / 108183708	ZFINID:	ZDB-GENE-120703-28	Length:	418	Species:	Danio rerio

Alignment Length:	298	Identity:	89/298 - (29%)
Similarity:	123/298 - (41%)	Gaps:	74/298 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SVHKEDGMPQFICVECAEAVRNAYRLR--------------RQCRKSHQYFEQLRLMMKELDDIE 99
            |:.|......|||.:|.:::....:|:              .||.||......|.|.|:
Zfish    43 SILKRKDKNCFICTQCGKSLSCKNKLKIHMMIHTGEKPFTCTQCGKSFSQLSSLNLHMR------ 101

  Fly   100 YCLNIGDNIEPQMPVSVMEAGKTPETSEPLLVELVQVKYMPPEPKPISSPLPDNNEHKLAQSYSP 164
              ::.|:.     |.:..:.||:                        .|.|...|.|....:...
Zfish   102 --IHTGEK-----PYTCTQCGKS------------------------YSQLSSLNLHMRIHTGEK 135

  Fly   165 AKTPHNKSKRRARSYSDNDSWSPDSELE-HEDDDKIWNASKRGKPKRVPGPYRCKLCTQSFTQKQ 228
            ..|.....|          |:|..|.|. |.   :|....|         |:.||.|.:||...:
Zfish   136 PFTCTQCGK----------SFSLLSSLNLHM---RIHTGEK---------PFTCKQCGKSFYNTR 178

  Fly   229 NLEIHMRIHTGERPYKCSLCPRSFAQKGNLQSHTRCHTGERPFGCPNCPKRFRQVGQLQVHTRTH 293
            ||.:|||||||||||.|..|.:||.:.|||..|.|.||||||:.|..|.|.|:..|.|.||.|.|
Zfish   179 NLTVHMRIHTGERPYTCQQCGKSFHKTGNLTVHMRIHTGERPYTCQQCGKSFQTTGNLTVHMRIH 243

  Fly   294 TGEQPFKCSKCQQSFKQLNGLQKHMSAHTRGKRRTSSQ 331
            |||:|:.|.:|.:|:.|.:.|:.||..|..|:....:|
Zfish   244 TGEKPYSCPQCGKSYSQNSNLEVHMRTHNGGRTFVCTQ 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17359	NP_648679.1	zf-AD	6..88	CDD:285071	11/52 (21%)
		zf-C2H2	215..237	CDD:278523	10/21 (48%)
		C2H2 Zn finger	217..237	CDD:275368	10/19 (53%)
		zf-H2C2_2	229..254	CDD:290200	17/24 (71%)
		C2H2 Zn finger	245..265	CDD:275368	9/19 (47%)
		zf-H2C2_2	257..282	CDD:290200	14/24 (58%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	286..310	CDD:290200	12/23 (52%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
si:dkey-22h13.1	XP_021331234.1	C2H2 Zn finger	55..75	CDD:275368	3/19 (16%)
		COG5048	79..>384	CDD:227381	82/262 (31%)
		C2H2 Zn finger	83..103	CDD:275368	7/27 (26%)
		C2H2 Zn finger	111..131	CDD:275368	6/43 (14%)
		C2H2 Zn finger	139..159	CDD:275368	6/32 (19%)
		C2H2 Zn finger	167..187	CDD:275368	10/19 (53%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	1/3 (33%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
		C2H2 Zn finger	363..383	CDD:275368
		C2H2 Zn finger	390..410	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930