Protein Alignment CtsK1 and Ctsb

DIOPT Version :10

• Sequence 1: NP_620470.1
• Gene: CtsK1 / 39547
• FlyBaseID: FBgn0250848
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_072119.2
• Gene: Ctsb / 64529
• RGDID: 621509
• Length: 339
• Species: Rattus norvegicus
• Alignment Length: 357
• Identity: 88/357 - (24%)
• Similarity: 139/357 - (38%)
• Gaps: 87/357 - (24%)

  Fly   229 PMQEFISGTDEHVDKAFHHFKRKHGVAYHSDTEHEHRKNIFRQNLRYIHSKN----RAKLTYTLA 289
            |:...::.|..|...:||..         ||           ..:.||:.:|    ..:..|.:.
  Rat     7 PLSCLLALTSAHDKPSFHPL---------SD-----------DMINYINKQNTTWQAGRNFYNVD 51

  Fly   290 VNHLADKTEEELKARRGYKSSGIYNTGKPFPYDVPKYKD-EIPDQYD----WRLYGAVTPVKDQS 349
            :::|.             |..|....|...|..|...:| .:|:.:|    |.....:..::||.
  Rat    52 ISYLK-------------KLCGTVLGGPKLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQG 103

  Fly   350 VCGSCWSFGTIGHLEGAFFLKNGGNL-VRLSQQALIDCSWAYGNNGCDGGEDFRVYQ-WM---LQ 409
            .|||||:||.:..:.....:...|.: |.:|.:.|:.|......:||:||.....:. |.   |.
  Rat   104 SCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLV 168

  Fly   410 SGGVPTEEEYGPYLGQDGY----C--HVN---------------NVTLVAPIK---------GFV 444
            ||||     |..::|...|    |  |||               |....|...         |:.
  Rat   169 SGGV-----YNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYT 228

  Fly   445 NVTSNDPNAFKLA-LLKHGPLSVAIDASPKTFSFYSHGVYYEPTCKNDVDGLDHAVLAVGYGSIN 508
            :.:.:|.....:| :.|:||:..|.... ..|..|..|||....  .||.| .||:..:|:|..|
  Rat   229 SYSVSDSEKEIMAEIYKNGPVEGAFTVF-SDFLTYKSGVYKHEA--GDVMG-GHAIRILGWGIEN 289

  Fly   509 GEDYWLVKNSWSTYWGNDGYILMSAKKNNCGV 540
            |..||||.|||:..||::|:..:...:|:||:
  Rat   290 GVPYWLVANSWNVDWGDNGFFKILRGENHCGI 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK1	NP_620470.1	Inhibitor_I29	245..300	CDD:214853	9/58 (16%)
		Peptidase_C1A	331..547	CDD:239068	70/250 (28%)
Ctsb	NP_072119.2	Peptidase_C1A_CathepsinB	81..328	CDD:239111	70/250 (28%)
		Propeptide_C1	26..65	CDD:462365	9/71 (13%)