DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 26-29-p and Ctsz

DIOPT Version :9

Sequence 1:	NP_620470.1	Gene:	26-29-p / 39547	FlyBaseID:	FBgn0250848	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_071720.1	Gene:	Ctsz / 64138	MGIID:	1891190	Length:	306	Species:	Mus musculus

Alignment Length:	269	Identity:	76/269 - (28%)
Similarity:	121/269 - (44%)	Gaps:	56/269 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 LKARRGYKSSGIYNTGKPFPYDVPKYKDEIPDQYDWR-----LYGAVTPVKDQSV---CGSCWSF 357
            |..||.|.        :|..|..|.   ::|..:|||     .|.:||  ::|.:   |||||:.
Mouse    46 LLGRRTYP--------RPHEYLSPA---DLPKNWDWRNVNGVNYASVT--RNQHIPQYCGSCWAH 97

  Fly   358 GTIGHLEGAFFLKNGG--NLVRLSQQALIDCSWAYGNNG-CDGGEDFRVYQWMLQSGGVPTEEEY 419
            |:...:.....:|..|  ..:.||.|.:|||    ||.| |:||.|..|::: ....|:| :|..
Mouse    98 GSTSAMADRINIKRKGAWPSILLSVQNVIDC----GNAGSCEGGNDLPVWEY-AHKHGIP-DETC 156

  Fly   420 GPYLGQD---------------GYCH-VNNVTLVAPIKGFVNVTSNDPNAFKLALLKHGPLSVAI 468
            ..|..:|               ..|| :.|.||.. :..:.:::..:  .....:..:||:|..|
Mouse   157 NNYQAKDQDCDKFNQCGTCTEFKECHTIQNYTLWR-VGDYGSLSGRE--KMMAEIYANGPISCGI 218

  Fly   469 DASPKTFSFYSHGVYYEPTCKNDVDGLDHAVLAVGYG-SINGEDYWLVKNSWSTYWGNDGY--IL 530
            .|: :..|.|:.|:|.|   ..|...::|.:...|:| |.:|.:||:|:|||...||..|:  |:
Mouse   219 MAT-EMMSNYTGGIYAE---HQDQAVINHIISVAGWGVSNDGIEYWIVRNSWGEPWGEKGWMRIV 279

  Fly   531 MSAKKNNCG 539
            .|..|...|
Mouse   280 TSTYKGGTG 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
26-29-p	NP_620470.1	Inhibitor_I29	245..300	CDD:214853
26-29-p	NP_620470.1	Peptidase_C1A	331..547	CDD:239068	69/239 (29%)
Ctsz	NP_071720.1	Peptidase_C1A_CathepsinX	64..305	CDD:239149	69/240 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810