DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 26-29-p and ctsf

DIOPT Version :9

Sequence 1:	NP_620470.1	Gene:	26-29-p / 39547	FlyBaseID:	FBgn0250848	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001071036.1	Gene:	ctsf / 565588	ZFINID:	ZDB-GENE-030131-9831	Length:	473	Species:	Danio rerio

Alignment Length:	326	Identity:	105/326 - (32%)
Similarity:	156/326 - (47%)	Gaps:	34/326 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 PMQEFISGTDEHVDKAFHHFKRKHGVAYHSDTEHEHRKNIFRQNLR---YIHSKNRAKLTYTLAV 290
            ||:|.:     .:...|.:|...:...|.|..|.|.|..||:||::   .:.|..:....|  .:
Zfish   164 PMKESV-----ELLTMFKNFMITYNRTYSSQEEAEKRLRIFQQNMKTAQTLQSLEQGSAEY--GI 221

  Fly   291 NHLADKTEEELKARRGYKSS-----GIYNTGKP-FPYDVPKYKDEIPDQYDWRLYGAVTPVKDQS 349
            ...:|.||:|.  |..|.:.     .:....|| .|...|     .||.:|||.:|||:|||:|.
Zfish   222 TKFSDLTEDEF--RMMYLNPMLSQWSLKKEMKPAIPASAP-----APDTWDWRDHGAVSPVKNQG 279

  Fly   350 VCGSCWSFGTIGHLEGAFFLKNGGNLVRLSQQALIDCSWAYGNNGCDGGEDFRVYQWMLQSGGVP 414
            :|||||:|...|::||.:| |..|.|:.||:|.|:||...  :..|.||.....|:.:...||:.
Zfish   280 MCGSCWAFSVTGNIEGQWF-KKTGQLLSLSEQELVDCDKL--DQACGGGLPSNAYEAIENLGGLE 341

  Fly   415 TEEEYGPYLGQDGYCHVNNVTLVAPIKGFVNVTSNDPN--AFKLALLKHGPLSVAIDASPKTFSF 477
            ||.:|. |.|....|..:...:.|.|...|.:..::..  ||   |.::||:|.|::|.  ...|
Zfish   342 TETDYS-YTGHKQSCDFSTGKVAAYINSSVELPKDEKEIAAF---LAENGPVSAALNAF--AMQF 400

  Fly   478 YSHGVYYEPTCKNDVDGLDHAVLAVGYGSINGEDYWLVKNSWSTYWGNDGYILMSAKKNNCGVMT 542
            |..||.:......:...:|||||.||:|..||..:|.:||||...:|..||..:......||:..
Zfish   401 YRKGVSHPLKIFCNPWMIDHAVLLVGFGQRNGVPFWAIKNSWGEDYGEQGYYYLYRGSGLCGIHK 465

  Fly   543 M 543
            |
Zfish   466 M 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
26-29-p	NP_620470.1	Inhibitor_I29	245..300	CDD:214853	16/57 (28%)
26-29-p	NP_620470.1	Peptidase_C1A	331..547	CDD:239068	79/215 (37%)
ctsf	NP_001071036.1	CY	34..144	CDD:214484
		PTZ00203	143..472	CDD:185513	105/326 (32%)
		Inhibitor_I29	175..231	CDD:214853	16/57 (28%)
		Peptidase_C1	262..471	CDD:278538	78/214 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820