Protein Alignment CtsK1 and Ctsf

DIOPT Version :10

• Sequence 1: NP_620470.1
• Gene: CtsK1 / 39547
• FlyBaseID: FBgn0250848
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_063914.1
• Gene: Ctsf / 56464
• MGIID: 1861434
• Length: 462
• Species: Mus musculus
• Alignment Length: 508
• Identity: 144/508 - (28%)
• Similarity: 221/508 - (43%)
• Gaps: 100/508 - (19%)

  Fly    80 LLKLAPITTKTENNKLTCLQVNGTAD--QAVDI--QSILPDAKPFSL--------VGTESFLGYT 132
            ||:|..:.|......|:.:.....||  ||.::  |.:|..|: |:|        .||.:.||..
Mouse     4 LLQLLWLLTLLSTVALSPVPAKPWADDEQAWNLSSQELLAPAR-FALDMYNYGRAAGTRAVLGAV 67

  Fly   133 CDKFRLESTIGQKKNIYTLWVRYKKSP-------HYPSSRMPIPVRYEMRGYNTLLGSHYDHYYL 190
            ..:.|   ..|| .::::|....::.|       ..|.::..:...:|      :|....:|..|
Mouse    68 RGRVR---RAGQ-GSLFSLEATLEEPPCNDPLVCPLPETKKTVLCSFE------VLEELKEHLLL 122

  Fly   191 DYDSYEHDDIPNEVFEIDDSLQCVGFPGPGTGHYATFNPM-------QEFISGTDEHVDKAFHHF 248
            ..|.   ..:..:|.|..::.            :::|.|:       |:|    ...:...|..|
Mouse   123 RRDC---SPVNAKVTEFRNAT------------FSSFLPLLDKDPLPQDF----SVKMAPLFKDF 168

  Fly   249 KRKHGVAYHSDTEHEHRKNIFRQNL---RYIHSKNRAKLTYTLAVNHLADKTEEE---------L 301
            ...:...|.|..|.:.|..:|.:|:   :.|.:.:|....|  .:...:|.||||         |
Mouse   169 MTTYNRTYESREEAQWRLTVFARNMIRAQKIQALDRGTAQY--GITKFSDLTEEEFHTIYLNPLL 231

  Fly   302 KARRGYKSSGIYNTGKPFPYDVPKYKDEIPDQYDWRLYGAVTPVKDQSVCGSCWSFGTIGHLEGA 366
            :...|.|.|           ......|..|.::|||..||||.||:|.:|||||:|...|::||.
Mouse   232 QKESGRKMS-----------PAKSINDLAPPEWDWRKKGAVTEVKNQGMCGSCWAFSVTGNVEGQ 285

  Fly   367 FFLKNGGNLVRLSQQALIDCSWAYGNNGCDGGEDFRVYQWMLQSGGVPTEEEYGPYLGQDGYCHV 431
            :|| |.|.|:.||:|.|:||...  :..|.||.....|..:...||:.||::|| |.|     ||
Mouse   286 WFL-NRGTLLSLSEQELLDCDKV--DKACLGGLPSNAYAAIKNLGGLETEDDYG-YQG-----HV 341

  Fly   432 NNVTLVAPI-KGFVNVT---SNDPNAFKLALLKHGPLSVAIDASPKTFSFYSHGVY--YEPTCKN 490
            ......|.: |.::|.:   |.:.|.....|.:.||:||||:|.  ...||.||:.  :.|.|..
Mouse   342 QTCNFSAQMAKVYINDSVELSRNENKIAAWLAQKGPISVAINAF--GMQFYRHGIAHPFRPLCSP 404

  Fly   491 DVDGLDHAVLAVGYGSINGEDYWLVKNSWSTYWGNDGYILMSAKKNNCGVMTM 543
            ..  :|||||.||||:.:...||.:||||.:.||.:||..:......|||.||
Mouse   405 WF--IDHAVLLVGYGNRSNIPYWAIKNSWGSDWGEEGYYYLYRGSGACGVNTM 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK1	NP_620470.1	Inhibitor_I29	245..300	CDD:214853	14/57 (25%)
		Peptidase_C1A	331..547	CDD:239068	88/219 (40%)
Ctsf	NP_063914.1	Inhibitor_I29	165..221	CDD:214853	14/57 (25%)
		Peptidase_C1	249..460	CDD:425470	88/220 (40%)