Protein Alignment CtsK1 and Ctsl

DIOPT Version :10

• Sequence 1: NP_620470.1
• Gene: CtsK1 / 39547
• FlyBaseID: FBgn0250848
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_037288.1
• Gene: Ctsl / 25697
• RGDID: 2448
• Length: 334
• Species: Rattus norvegicus
• Alignment Length: 324
• Identity: 131/324 - (40%)
• Similarity: 180/324 - (55%)
• Gaps: 30/324 - (9%)

  Fly   238 DEHVDKAFHHFKRKHGVAYHSDTEHEHRKNIFRQNLRYIHSKN----RAKLTYTLAVNHLADKTE 298
            |:..:..:|.:|..|...|.:: |.|.|:.::.:|:|.|...|    ..|..:|:.:|...|.|.
  Rat    22 DQTFNAQWHQWKSTHRRLYGTN-EEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85

  Fly   299 EELK-ARRGYKSSGIYNTGKPFPYDVPKYKDEIPDQYDWRLYGAVTPVKDQSVCGSCWSFGTIGH 362
            ||.: ...||:... :..|:.|...:..   :||...|||..|.|||||:|..|||||:|...|.
  Rat    86 EEFRQIVNGYRHQK-HKKGRLFQEPLML---QIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGC 146

  Fly   363 LEGAFFLKNGGNLVRLSQQALIDCSWAYGNNGCDGG-EDFRVYQWMLQSGGVPTEEEYGPYLGQD 426
            |||..|||. |.|:.||:|.|:|||...||.||:|| .|| .:|::.::||:.:||.| ||..:|
  Rat   147 LEGQMFLKT-GKLISLSEQNLVDCSHDQGNQGCNGGLMDF-AFQYIKENGGLDSEESY-PYEAKD 208

  Fly   427 GYCHVNNVTLVAPIKGFVNVTSNDPNAFKLALLKH----GPLSVAIDASPKTFSFYSHGVYYEPT 487
            |.|.......||...|||::...:.     ||:|.    ||:|||:|||..:..|||.|:||||.
  Rat   209 GSCKYRAEYAVANDTGFVDIPQQEK-----ALMKPVATVGPISVAMDASHPSLQFYSSGIYYEPN 268

  Fly   488 CKNDVDGLDHAVLAVGYG----SINGEDYWLVKNSWSTYWGNDGYILMSAKKNN-CGVMTMPTY 546
            |.:  ..|||.||.||||    ..|.:.||||||||...||.||||.::..:|| ||:.|..:|
  Rat   269 CSS--KDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASY 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK1	NP_620470.1	Inhibitor_I29	245..300	CDD:214853	16/58 (28%)
		Peptidase_C1A	331..547	CDD:239068	107/226 (47%)
Ctsl	NP_037288.1	Inhibitor_I29	29..87	CDD:214853	16/58 (28%)
		Peptidase_C1	114..332	CDD:425470	108/227 (48%)