Protein Alignment CtsK1 and CTSS

DIOPT Version :10

• Sequence 1: NP_620470.1
• Gene: CtsK1 / 39547
• FlyBaseID: FBgn0250848
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_004070.3
• Gene: CTSS / 1520
• HGNCID: 2545
• Length: 331
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 119/333 - (35%)
• Similarity: 173/333 - (51%)
• Gaps: 43/333 - (12%)

  Fly   238 DEHVDKAFHHFKRKHGVAYHSDTEHEHRKNIFRQNLRYI------HSKNRAKLTYTLAVNHLADK 296
            |..:|..:|.:|:.:|..|....|...|:.|:.:||:::      ||....  :|.|.:|||.|.
Human    21 DPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMH--SYDLGMNHLGDM 83

  Fly   297 TEEELKARRG-------------YKSSGIYNTGKPFPYDVPKYKDEIPDQYDWRLYGAVTPVKDQ 348
            |.||:.:...             |||:         |..:      :||..|||..|.||.||.|
Human    84 TSEEVMSLMSSLRVPSQWQRNITYKSN---------PNRI------LPDSVDWREKGCVTEVKYQ 133

  Fly   349 SVCGSCWSFGTIGHLEGAFFLKNGGNLVRLSQQALIDCSW-AYGNNGCDGGEDFRVYQWMLQSGG 412
            ..||:||:|..:|.||....||. |.||.||.|.|:|||. .|||.||:||.....:|:::.:.|
Human   134 GSCGACWAFSAVGALEAQLKLKT-GKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKG 197

  Fly   413 VPTEEEYGPYLGQDGYCHVNNVTLVAPIKGFVNVTSNDPNAFKLALLKHGPLSVAIDASPKTFSF 477
            :.::..| ||...|..|..::....|....:..:.....:..|.|:...||:||.:||...:|..
Human   198 IDSDASY-PYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFL 261

  Fly   478 YSHGVYYEPTCKNDVDGLDHAVLAVGYGSINGEDYWLVKNSWSTYWGNDGYILMSAKK-NNCGVM 541
            |..||||||:|..:|   :|.||.||||.:||::||||||||...:|.:|||.|:..| |:||:.
Human   262 YRSGVYYEPSCTQNV---NHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIA 323

  Fly   542 TMPTYVEM 549
            :.|:|.|:
Human   324 SFPSYPEI 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK1	NP_620470.1	Inhibitor_I29	245..300	CDD:214853	18/60 (30%)
		Peptidase_C1A	331..547	CDD:239068	91/217 (42%)
CTSS	NP_004070.3	Inhibitor_I29	28..87	CDD:214853	18/60 (30%)
		Peptidase_C1	115..329	CDD:425470	91/218 (42%)