Protein Alignment CtsK1 and CTSB

DIOPT Version :10

• Sequence 1: NP_620470.1
• Gene: CtsK1 / 39547
• FlyBaseID: FBgn0250848
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001899.1
• Gene: CTSB / 1508
• HGNCID: 2527
• Length: 339
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 69/277 - (24%)
• Similarity: 112/277 - (40%)
• Gaps: 62/277 - (22%)

  Fly   311 GIYNTGKPFPYDVPKYKD-EIPDQYD----WRLYGAVTPVKDQSVCGSCWSFGTIGHLEGAFFLK 370
            |.:..|...|..|...:| ::|..:|    |.....:..::||..|||||:||.:..:.....:.
Human    60 GTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIH 124

  Fly   371 NGGNL-VRLSQQALIDCSWAYGNNGCDGGEDFRVYQ-WM---LQSGGV-------------PTEE 417
            ...:: |.:|.:.|:.|..:...:||:||.....:. |.   |.|||:             |.|.
Human   125 TNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEH 189

  Fly   418 E------------------------YGPYLGQDGYCHVNNVTLVAPIKGFVNVTSNDPNAFKLAL 458
            .                        |.|...||.:...|:.::           ||........:
Human   190 HVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSV-----------SNSEKDIMAEI 243

  Fly   459 LKHGPLSVAIDASPKTFSFYSHGVYYEPTCKNDVDGLDHAVLAVGYGSINGEDYWLVKNSWSTYW 523
            .|:||:..|.... ..|..|..|||...|  .::.| .||:..:|:|..||..||||.|||:|.|
Human   244 YKNGPVEGAFSVY-SDFLLYKSGVYQHVT--GEMMG-GHAIRILGWGVENGTPYWLVANSWNTDW 304

  Fly   524 GNDGYILMSAKKNNCGV 540
            |::|:..:...:::||:
Human   305 GDNGFFKILRGQDHCGI 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsK1	NP_620470.1	Inhibitor_I29	245..300	CDD:214853
		Peptidase_C1A	331..547	CDD:239068	64/256 (25%)
CTSB	NP_001899.1	Propeptide_C1	26..65	CDD:462365	1/4 (25%)
		Peptidase_C1A_CathepsinB	81..328	CDD:239111	64/256 (25%)