DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 26-29-p and Ctsk

DIOPT Version :9

Sequence 1:	NP_620470.1	Gene:	26-29-p / 39547	FlyBaseID:	FBgn0250848	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_031828.2	Gene:	Ctsk / 13038	MGIID:	107823	Length:	329	Species:	Mus musculus

Alignment Length:	335	Identity:	131/335 - (39%)
Similarity:	188/335 - (56%)	Gaps:	29/335 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 PMQEFISGTDEHVDKAFHHFKRKHGVAYHSDTEHEHRKNIFRQNLRYIHSKN-RAKL---TYTLA 289
            ||..|....:|.:|..:..:|:.|...|:|..:...|:.|:.:||:.|.:.| .|.|   ||.||
Mouse    10 PMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELA 74

  Fly   290 VNHLADKTEEELKAR---------RGYKSSGIYNTGKPFPYDVPKYKDEIPDQYDWRLYGAVTPV 345
            :|||.|.|.||:..:         |.|.:..:|         .|:::..:||..|:|..|.||||
Mouse    75 MNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLY---------TPEWEGRVPDSIDYRKKGYVTPV 130

  Fly   346 KDQSVCGSCWSFGTIGHLEGAFFLKNGGNLVRLSQQALIDCSWAYGNNGCDGGEDFRVYQWMLQS 410
            |:|..|||||:|.:.|.|||. ..|..|.|:.||.|.|:||  ...|.||.||.....:|::.|:
Mouse   131 KNQGQCGSCWAFSSAGALEGQ-LKKKTGKLLALSPQNLVDC--VTENYGCGGGYMTTAFQYVQQN 192

  Fly   411 GGVPTEEEYGPYLGQDGYCHVNNVTLVAPIKGFVNVTSNDPNAFKLALLKHGPLSVAIDASPKTF 475
            ||:.:|:.| ||:|||..|..|.....|..:|:..:...:..|.|.|:.:.||:||:||||..:|
Mouse   193 GGIDSEDAY-PYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASF 256

  Fly   476 SFYSHGVYYEPTCKNDVDGLDHAVLAVGYGSINGEDYWLVKNSWSTYWGNDGYILMSAKKNN-CG 539
            .|||.||||:..|  |.|.::||||.||||:..|..:|::||||...|||.||.|::..||| ||
Mouse   257 QFYSRGVYYDENC--DRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACG 319

  Fly   540 VMTMPTYVEM 549
            :..|.::.:|
Mouse   320 ITNMASFPKM 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
26-29-p	NP_620470.1	Inhibitor_I29	245..300	CDD:214853	21/58 (36%)
26-29-p	NP_620470.1	Peptidase_C1A	331..547	CDD:239068	98/216 (45%)
Ctsk	NP_031828.2	Inhibitor_I29	26..85	CDD:214853	21/58 (36%)
Ctsk	NP_031828.2	Peptidase_C1A	116..327	CDD:239068	98/216 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830