DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 26-29-p and CTSC

DIOPT Version :9

Sequence 1:	NP_620470.1	Gene:	26-29-p / 39547	FlyBaseID:	FBgn0250848	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001805.4	Gene:	CTSC / 1075	HGNCID:	2528	Length:	463	Species:	Homo sapiens

Alignment Length:	311	Identity:	90/311 - (28%)
Similarity:	148/311 - (47%)	Gaps:	37/311 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 VAYHSDTEHEHRKNIFRQNLRYIHSKNRAKLTYTLAVNHLADKTEEELKARRGYKSSGIYNTGKP 318
            :|:..:::.::...:::.:..::.:.|..:.::| |..::..:|   |......:.||.::...|
Human   153 IAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWT-ATTYMEYET---LTLGDMIRRSGGHSRKIP 213

  Fly   319 FPYDVPKYKD------EIPDQYDWR-LYGA--VTPVKDQSVCGSCWSFGTIGHLEGAF-FLKNGG 373
            .|...|...:      .:|..:||| ::|.  |:||::|:.||||:||.::|.||... .|.|..
Human   214 RPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNS 278

  Fly   374 NLVRLSQQALIDCSWAYGNNGCDGGEDFRVYQWMLQSGGVPTEEEYGPYLGQDGYC--------- 429
            ....||.|.::.|| .|. .||:||..:.:.....|..|: .||...||.|.|..|
Human   279 QTPILSPQEVVSCS-QYA-QGCEGGFPYLIAGKYAQDFGL-VEEACFPYTGTDSPCKMKEDCFRY 340

  Fly   430 HVNNVTLVAPIKGFVNVTSNDPNAFKLALLKHGPLSVAIDASPKTFSFYSHGVYYEPTCK---ND 491
            :.:....|....|..|..     ..||.|:.|||::||.:.. ..|..|..|:|:....:   |.
Human   341 YSSEYHYVGGFYGGCNEA-----LMKLELVHHGPMAVAFEVY-DDFLHYKKGIYHHTGLRDPFNP 399

  Fly   492 VDGLDHAVLAVGYG--SINGEDYWLVKNSWSTYWGNDGYILMSAKKNNCGV 540
            .:..:||||.||||  |.:|.|||:|||||.|.||.:||..:....:.|.:
Human   400 FELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAI 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
26-29-p	NP_620470.1	Inhibitor_I29	245..300	CDD:214853	5/45 (11%)
26-29-p	NP_620470.1	Peptidase_C1A	331..547	CDD:239068	79/228 (35%)
CTSC	NP_001805.4	CathepsinC_exc	26..138	CDD:312344
CTSC	NP_001805.4	Peptidase_C1A_CathepsinC	231..460	CDD:239112	79/229 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820