DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and SSA4

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_011029.3	Gene:	SSA4 / 856840	SGDID:	S000000905	Length:	642	Species:	Saccharomyces cerevisiae

Alignment Length:	639	Identity:	451/639 - (70%)
Similarity:	535/639 - (83%)	Gaps:	3/639 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDA 70
            |||||||||||||..|.:.:||||||||||||||||||||::|||||||||||.||||:||:|||
Yeast     4 AVGIDLGTTYSCVAHFANDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQAAMNPHNTVFDA 68

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYL 135
            ||||||:|||..|.:|.||:||:|..:.|||.::||||||.|:|.|||:|||:||||:||||.:|
Yeast    69 KRLIGRKFDDPEVTNDAKHYPFKVIDKGGKPVVQVEYKGETKTFTPEEISSMILTKMKETAENFL 133

  Fly   136 GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFDL 200
            |..|.||||||||||||||||||||||.||||||||||||||||||||||||:...|.|||||||
Yeast   134 GTEVKDAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKSQKEHNVLIFDL 198

  Fly   201 GGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRT 265
            ||||||||:|:|::|:||||||||||||||||||:||||...:||:||:||||..|:|:||||||
Yeast   199 GGGTFDVSLLSIDEGVFEVKATAGDTHLGGEDFDSRLVNFLAEEFKRKNKKDLTTNQRSLRRLRT 263

  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQ 330
            |.||||||||||.|.||||||||||:|||||:||||||||..||||.|:|||.|.|.|:|:||.|
Yeast   264 AAERAKRTLSSSAQTSIEIDSLFEGIDFYTSITRARFEELCADLFRSTLEPVEKVLADSKLDKSQ 328

  Fly   331 IHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLD 395
            |.:||||||||||||||:|:.|||||||.|:|||||||||||||||||||.||:|...|||||||
Yeast   329 IDEIVLVGGSTRIPKVQKLVSDFFNGKEPNRSINPDEAVAYGAAVQAAILTGDQSSTTQDLLLLD 393

  Fly   396 VTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFE 460
            |.|||||||||||:||.||.||:|||||::::|:||||||||||||||||||..|:|||.|||||
Yeast   394 VAPLSLGIETAGGIMTKLIPRNSTIPTKKSEVFSTYADNQPGVLIQVFEGERTRTKDNNLLGKFE 458

  Fly   461 LSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEAY 525
            ||.||||||||||:||||||||||||||:|:||.|||.|:|||||||||||||||::||.:||.:
Yeast   459 LSGIPPAPRGVPQIEVTFDIDANGILNVSAVEKGTGKSNKITITNDKGRLSKEDIDKMVAEAEKF 523

  Fly   526 RQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQLAERQ 590
            :..|||:..|:.||||||||.|.|::::.:.:...:....|...::..:.:.|.||||:|.|..:
Yeast   524 KAEDEQEAQRVQAKNQLESYAFTLKNSVSENNFKEKVGEEDARKLEAAAQDAINWLDASQAASTE 588

  Fly   591 EFEHKQQELERICSPIITRLYQGAGMAP---PPTAGGSNPGATGGSGPTIEEVD 641
            |::.:|:|||.:.:||:::.|..||.||   |....|:.|.....:|||:||||
Yeast   589 EYKERQKELEGVANPIMSKFYGAAGGAPGAGPVPGAGAGPTGAPDNGPTVEEVD 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	449/637 (70%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	293/374 (78%)
SSA4	NP_011029.3	PTZ00009	4..642	CDD:240227	449/637 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	907	1.000	Domainoid score	I1
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	944	1.000	Inparanoid score	I36
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		mtm9161
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
TreeFam	1	0.960	-	-
	12	11.830