Protein Alignment Hsc70-1 and LHS1

DIOPT Version :10

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_012850.1
• Gene: LHS1 / 853789
• SGDID: S000001556
• Length: 881
• Species: Saccharomyces cerevisiae
• Alignment Length: 678
• Identity: 160/678 - (23%)
• Similarity: 298/678 - (43%)
• Gaps: 81/678 - (11%)

  Fly     7 VGIDLG-TTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTE-----------SERLIGDAAKNQV 59
            :|:|.| .....:.|.....:|::...:..|...|.::...           .||:.|.|..:..
Yeast    23 LGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVGSLA 87

  Fly    60 AMNPNNTIFDAKRLIGRRFDDATVQS--DMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSM 122
            ...|.||:...|.|:|:..:|.|..:  ..:|...|:.:.|   |..:.:..:...:..||:.:|
Yeast    88 TRFPQNTLLHLKPLLGKSLEDETTVTLYSKQHPGLEMVSTN---RSTIAFLVDNVEYPLEELVAM 149

  Fly   123 VLTKMRETAEAYLGGT-------VTDAVVTVPAYFNDSQRQATKDAGAI-AGLNVLRIINEPTAA 179
            .:.::...|.:.|...       |.....|:|.:|:..||:|..||.:| .|:....:::|..:.
Yeast   150 NVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEETYLVSEGMSV 214

  Fly   180 AIAYGLDKQ---GTSERNVLIFDLGGGTFDVSVLTI---EDG----IFEVKATAGDTHLGGE--- 231
            |:.:.|.::   ...:::.:::|:|.|:...|:.:|   ||.    ..|.:....:.||||.
Yeast   215 AVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGYNPHLGGAKFT 279

  Fly   232 -DFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYT 295
             |..:.:.|.|::........:|..|.:||.::..|.|:||..||::::|||.|:||...:||.|
Yeast   280 MDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANSEASINIESLINDIDFRT 344

  Fly   296 SVTRARFEELNGDLFRGTMEPVAKALRDAKMDKG------QIHDIVLVGGSTRIPKVQRLLQDFF 354
            |:||..|||...|.....::|:..|:  .|...|      :|:.::|.|||:|||.||..|....
Yeast   345 SITRQEFEEFIADSLLDIVKPINDAV--TKQFGGYGTNLPEINGVILAGGSSRIPIVQDQLIKLV 407

  Fly   355 NGKELNKSINPDEAVAYGAAVQAAILHGDK---SEAVQDLLLLD--VTPLSLGIETAGGVMTTLI 414
            :.:::.:::|.||     :||...::.|.|   |...:.|.::|  |...|..:... ..:..:.
Yeast   408 SEEKVLRNVNADE-----SAVNGVVMRGIKLSNSFKTKPLNVVDRSVNTYSFKLSNE-SELYDVF 466

  Fly   415 KRNTTIPTKQTQIFTTYADNQP-GVLIQVFEGERAMTRDNNSLGKFELS-AIPPAPRGVPQVEVT 477
            .|.:..|.| |.|.|...|:.| ...|.:||..:.......:.|..:.| :......|| ...:|
Yeast   467 TRGSAYPNK-TSILTNTTDSIPNNFTIDLFENGKLFETITVNSGAIKNSYSSDKCSSGV-AYNIT 529

  Fly   478 FDIDANGILNVTALEKSTGKENRI----TITNDKGRL--SKEDIE-RMVNDAEAYR------QAD 529
            ||:.::.:.::..:......||.|    .|.|...||  :.||:| :.::.:|..|      ..|
Yeast   530 FDLSSDRLFSIQEVNCICQSENDIGNSKQIKNKGSRLAFTSEDVEIKRLSPSERSRLHEHIKLLD 594

  Fly   530 EQQRDRINAK---NQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWL-DANQLAERQ 590
            :|.::|...:   |.|||..:..|:.|.|:.:......:..|.:.:.....:.|| ||:...:.:
Yeast   595 KQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNGPKSQVEELSEMVKVYLDWLEDASFDTDPE 659

  Fly   591 EFEHKQQELERICSPIITRLYQGAGMAP 618
            :...:.:|:..:...|  .||..:...|
Yeast   660 DIVSRIREIGILKKKI--ELYMDSAKEP 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	160/678 (24%)
LHS1	NP_012850.1	ASKHA_NBD_HSP70_HYOU1	21..431	CDD:466828	103/417 (25%)