Protein Alignment Hsc70-1 and KAR2

DIOPT Version :10

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_012500.3
• Gene: KAR2 / 853418
• SGDID: S000003571
• Length: 682
• Species: Saccharomyces cerevisiae
• Alignment Length: 609
• Identity: 362/609 - (59%)
• Similarity: 476/609 - (78%)
• Gaps: 5/609 - (0%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDAK 71
            :|||||||||||.|.::||.||:||:||||.||||||||:.|||||||||||||.||.|||||.|
Yeast    53 IGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFTDDERLIGDAAKNQVAANPQNTIFDIK 117

  Fly    72 RLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYLG 136
            ||||.:::|.:||.|:||.||.|..::|||.:.|..|||:|.|.|||:|.|:|.||::.||.|||
Yeast   118 RLIGLKYNDRSVQKDIKHLPFNVVNKDGKPAVEVSVKGEKKVFTPEEISGMILGKMKQIAEDYLG 182

  Fly   137 GTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFDLG 201
            ..||.|||||||||||:|||||||||.|||||||||:|||||||||||||| ...|..::::|||
Yeast   183 TKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDK-SDKEHQIIVYDLG 246

  Fly   202 GGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRTA 266
            |||||||:|:||:|:|||:||:|||||||||||.::|...::.|::||..|:..|.:||.:|:..
Yeast   247 GGTFDVSLLSIENGVFEVQATSGDTHLGGEDFDYKIVRQLIKAFKKKHGIDVSDNNKALAKLKRE 311

  Fly   267 CERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQI 331
            .|:|||.|||.....|||||..:|:|...::|||:|||||.|||:.|::||.|.|:|:.::|..:
Yeast   312 AEKAKRALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLQDSGLEKKDV 376

  Fly   332 HDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDV 396
            .|||||||||||||||:||:.:|:||:.:|.|||||||||||||||.:|.|:  |.|:|::||||
Yeast   377 DDIVLVGGSTRIPKVQQLLESYFDGKKASKGINPDEAVAYGAAVQAGVLSGE--EGVEDIVLLDV 439

  Fly   397 TPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFEL 461
            ..|:|||||.|||||.||||||.||||::|||:|..||||.|:|:|:||||||::|||.||||||
Yeast   440 NALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLLGKFEL 504

  Fly   462 SAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEAYR 526
            :.||||||||||:||||.:||||||.|:|.:|.|||...||||||||||::|:|:|||.:||.:.
Yeast   505 TGIPPAPRGVPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQEEIDRMVEEAEKFA 569

  Fly   527 QADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDAN-QLAERQ 590
            ..|...:.::.::|:||:|...|::.::.: |..:....|:||:...:::.:.|||.| :.|..:
Yeast   570 SEDASIKAKVESRNKLENYAHSLKNQVNGD-LGEKLEEEDKETLLDAANDVLEWLDDNFETAIAE 633

  Fly   591 EFEHKQQELERICSPIITRLYQGA 614
            :|:.|.:.|.::..||.::||.||
Yeast   634 DFDEKFESLSKVAYPITSKLYGGA 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	362/609 (59%)
KAR2	NP_012500.3	HSP70	52..654	CDD:394970	358/604 (59%)