DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and SSA3

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_009478.1	Gene:	SSA3 / 852203	SGDID:	S000000171	Length:	649	Species:	Saccharomyces cerevisiae

Alignment Length:	647	Identity:	464/647 - (71%)
Similarity:	546/647 - (84%)	Gaps:	12/647 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDA 70
            |||||||||||||..|.:.:||||||||||||||||||||::|||||||||||.|:||:||:|||
Yeast     4 AVGIDLGTTYSCVAHFSNDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQAAINPHNTVFDA 68

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYL 135
            ||||||:|||..|.:|.||:||:|.:.:|||.::||||||.|:|.|||:|||||:||:||||.||
Yeast    69 KRLIGRKFDDPEVTTDAKHFPFKVISRDGKPVVQVEYKGETKTFTPEEISSMVLSKMKETAENYL 133

  Fly   136 GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFDL 200
            |.||.||||||||||||||||||||||.|||:||||||||||||||||||||:|.:|.|||||||
Yeast   134 GTTVNDAVVTVPAYFNDSQRQATKDAGTIAGMNVLRIINEPTAAAIAYGLDKKGRAEHNVLIFDL 198

  Fly   201 GGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRT 265
            ||||||||:|:|::|:||||||||||||||||||||||||...||:||.|||:..|:|:||||||
Yeast   199 GGGTFDVSLLSIDEGVFEVKATAGDTHLGGEDFDNRLVNHLATEFKRKTKKDISNNQRSLRRLRT 263

  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQ 330
            |.|||||.||||:|.||||||||||:|||||:||||||||..||||.|:|||.|.|:|:|:||.|
Yeast   264 AAERAKRALSSSSQTSIEIDSLFEGMDFYTSLTRARFEELCADLFRSTLEPVEKVLKDSKLDKSQ 328

  Fly   331 IHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLD 395
            |.:||||||||||||:|:|:.|||||||.|:|||||||||||||||||||.||:|...|||||||
Yeast   329 IDEIVLVGGSTRIPKIQKLVSDFFNGKEPNRSINPDEAVAYGAAVQAAILTGDQSTKTQDLLLLD 393

  Fly   396 VTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFE 460
            |.|||||||||||:||.||.||:|||||:::.|:||||||||||||||||||..|:|||.|||||
Yeast   394 VAPLSLGIETAGGIMTKLIPRNSTIPTKKSETFSTYADNQPGVLIQVFEGERTRTKDNNLLGKFE 458

  Fly   461 LSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEAY 525
            ||.||||||||||::|||||||||||||:||||.|||.|:||||||||||||:||:|||::||.|
Yeast   459 LSGIPPAPRGVPQIDVTFDIDANGILNVSALEKGTGKSNKITITNDKGRLSKDDIDRMVSEAEKY 523

  Fly   526 RQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQLAERQ 590
            |..||::.:|:.||||||||.|.|::|:::.....:....|.:.::..|.|||.||||:|.|...
Yeast   524 RADDEREAERVQAKNQLESYAFTLKNTINEASFKEKVGEDDAKRLETASQETIDWLDASQAASTD 588

  Fly   591 EFEHKQQELERICSPIITRLYQGAGMAPPPTAGGS--------NPGATGG---SGPTIEEVD 641
            |::.:|:|||.|.:||:|:.| |||....|.||.|        |.|||||   :|||:||||
Yeast   589 EYKDRQKELEGIANPIMTKFY-GAGAGAGPGAGESGGFPGSMPNSGATGGGEDTGPTVEEVD 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	462/645 (72%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	293/374 (78%)
SSA3	NP_009478.1	PTZ00009	4..649	CDD:240227	462/645 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	907	1.000	Domainoid score	I1
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	944	1.000	Inparanoid score	I36
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		mtm9161
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
TreeFam	1	0.960	-	-
	12	11.830