DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and SSQ1

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_013473.1	Gene:	SSQ1 / 851084	SGDID:	S000004361	Length:	657	Species:	Saccharomyces cerevisiae

Alignment Length:	585	Identity:	263/585 - (44%)
Similarity:	380/585 - (64%)	Gaps:	43/585 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PKL--PAVGIDLGTTYSCVGVFQHG----KVEIIANDQGNRTTPSYVAF---------TESERLI 51
            |:|  ..:|||||||.|.|...:..    ...||.||:|.|||||.|||         .:.:.|:
Yeast    24 PQLTKKVIGIDLGTTNSAVAYIRDSNDKKSATIIENDEGQRTTPSIVAFDVKSSPQNKDQMKTLV 88

  Fly    52 GDAAKNQVAMNPNNTIFDAKRLIGRRFDDATVQSDMKHWPFEVF--AENGKPRIRVEYKGERKSF 114
            |.|||.|.|:|..||.|..||||||.|:|..||.||...|:::.  ..||:..:... .|..:|
Yeast    89 GMAAKRQNAINSENTFFATKRLIGRAFNDKEVQRDMAVMPYKIVKCESNGQAYLSTS-NGLIQS- 151

  Fly   115 YPEEVSSMVLTKMRETAEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAA 179
             |.:::|::|..:::|:|.|||..|..||:||||||||||||||||||.:|||||||:|||||||
Yeast   152 -PSQIASILLKYLKQTSEEYLGEKVNLAVITVPAYFNDSQRQATKDAGKLAGLNVLRVINEPTAA 215

  Fly   180 AIAYGLDKQGTSERN---VLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHF 241
            |:::|:|    .:||   :.::||||||||:|:|.||||:|||:||.||||||||||||.:||:.
Yeast   216 ALSFGID----DKRNNGLIAVYDLGGGTFDISILDIEDGVFEVRATNGDTHLGGEDFDNVIVNYI 276

  Fly   242 VQEFQRKH----KKDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARF 302
            :..|..::    ::::.:|:..::||:...||||..||...:..||:..:::.......:|....
Yeast   277 IDTFIHENPEITREEITKNRETMQRLKDVSERAKIDLSHVKKTFIELPFVYKSKHLRVPMTEEEL 341

  Fly   303 EELNGDLFRGTMEPVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDE 367
            :.:...|...|:.||.:||:||.::...|.:::||||.||:||::.:::|.| ||..|.|:||||
Yeast   342 DNMTLSLINRTIPPVKQALKDADIEPEDIDEVILVGGMTRMPKIRSVVKDLF-GKSPNSSVNPDE 405

  Fly   368 AVAYGAAVQAAILHGDKSEAVQDLLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYA 432
            .||.|||:|..||.|:    ::::||||||||:|||||.||..:.||.||||:|.|:|:||:|..
Yeast   406 TVALGAAIQGGILSGE----IKNVLLLDVTPLTLGIETFGGAFSPLIPRNTTVPVKKTEIFSTGV 466

  Fly   433 DNQPGVLIQVFEGERAMTRDNNSLGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGK 497
            |.|.||.|:||:|||.:.|:|..:|..:|:.|.|.|:|:||:.|||||||:||:||:|.|||:||
Yeast   467 DGQAGVDIKVFQGERGLVRNNKLIGDLKLTGITPLPKGIPQIYVTFDIDADGIINVSAAEKSSGK 531

  Fly   498 ENRITITNDKGRLSKEDIERMVNDAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRF 562
            :..||:..:.| ||:|:|.:::.:|.|.|..|...|.|:...::.:.      ...|.|:|..|:
Yeast   532 QQSITVIPNSG-LSEEEIAKLIEEANANRAQDNLIRQRLELISKADI------MISDTENLFKRY 589

Fly 563 562
Yeast 590 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	263/585 (45%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	178/396 (45%)
SSQ1	NP_013473.1	dnaK	29..656	CDD:234715	261/580 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810