Protein Alignment Hsc70-1 and Hspa12b

DIOPT Version :9

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_082582.1
• Gene: Hspa12b / 72630
• MGIID: 1919880
• Length: 685
• Species: Mus musculus
• Alignment Length: 645
• Identity: 136/645 - (21%)
• Similarity: 233/645 - (36%)
• Gaps: 175/645 - (27%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEII-------ANDQG--NRTTPSYVAFTESE--RLIGDAAKNQV- 59
            |.||.|||.|..........|.|       ..|.|  ::.||:.:..|...  ...|..|::..
Mouse    63 VAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGIFHSFGYTARDYYH 127

  Fly    60 AMNPNNT----IFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVS 120
            .::|...    .|:..::......|.|:::.::       |.|||..:.:|.......|:.|.
Mouse   128 DLDPEEARDWLYFEKFKMKIHSATDLTLKTQLE-------AVNGKKMLALEVFAHALRFFKEH-- 183

  Fly   121 SMVLTKMRETAEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGL------NVLRIINEPTAA 179
              .|.::||.:|..|.......|:||||.:....:|..::|..:|||      ..|.|..||.||
Mouse   184 --ALQELREQSECMLEKGAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALEPEAA 246

  Fly   180 AI----------------AYGLDKQG------TSERNV--------------------------- 195
            ::                ..|..:.|      :|.|:.
Mouse   247 SVYCRKLRLHQLMDLSSRTAGRGRLGERRSIDSSFRHAREQLRRSRHSRTFLVEAGVGELWAEMQ 311

  Fly   196 -----LIFDLGGGTFDVSVLTIED--GIFE--VKATAGDTHLGGED--FDNRLVNHFVQEFQRKH 249
                 ::.|.||||.|::|..:|.  |..:  .||:.|.....|.|  |:..|...|.::|..|.
Mouse   312 EGDRYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIAKF 376

  Fly   250 KKDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFY--------------TSVTRA 300
            |:   |...|...|..|.|..|||.......::.|...|..:|||              :||...
Mouse   377 KR---QRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNLV 438

  Fly   301 RFE---------ELNGDLFRGTMEPVAKALRD--AKMDKGQIHDIVLVGGSTRIPKVQRLLQDFF 354
            ::.         |...:||:.|:..:.:.:..  ||.:...:..:.||||......:|..:|:..
Mouse   439 KWSSQGMLRMSCEAMNELFQPTVSGIIQHIEMLLAKPEVQGVKLLFLVGGFAESAVLQHAVQEAL 503

  Fly   355 NGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDVTPLSLGIETAGGVMTTLI----- 414
            ..:.|...:..|..:   ..::.|:|.|.....|:    :..:||:.|:    ||:...:
Mouse   504 GTRGLRVVVPHDVGL---TILKGAVLFGQAPGVVR----VRRSPLTYGV----GVLNRFVPGHHP 557

  Fly   415 ---------KRNTT------IPTKQT-----QIFTTYADNQPG---VLIQVF----EGERAMTRD 452
                     :|..|      :..:|:     ::..:|...:||   |||.::    |..|.:|
Mouse   558 PEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFIT-- 620

  Fly   453 NNSLGKFELSAIPPAPRGVPQVEVTF----DIDA-----NGILNVTALEKSTGKENRITI 503
            :..:.|....::...|.|.|:...|.    :|.|     :..:.|||::.||.:..|..|
Mouse   621 DPGVRKCGALSLELEPEGCPENTGTSPSRREIRAAMQFGDTEIKVTAVDVSTNRSVRAAI 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	136/645 (21%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	102/480 (21%)
Hspa12b	NP_082582.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		NBD_sugar-kinase_HSP70_actin	61..529	CDD:302596	103/482 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810