Protein Alignment Hsc70-1 and Hspa2

DIOPT Version :9

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_068635.1
• Gene: Hspa2 / 60460
• RGDID: 620664
• Length: 633
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 503/639 - (78%)
• Similarity: 568/639 - (88%)
• Gaps: 13/639 - (2%)

  Fly     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFD 69
            ||:||||||||||||||||||||||||||||||||||||||::||||||||||||||||.|||||
  Rat     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    70 AKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAY 134
            |||||||:|:|||||||||||||.|.:|.|||:::||||||.|:|:|||:||||||||:|.||||
  Rat    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   135 LGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTS--ERNVLI 197
            |||.|..||:||||||||||||||||||.|.||||||||||||||||||||||:|.:  |:||||
  Rat   136 LGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   198 FDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRR 262
            |||||||||||:|||||||||||:|||||||||||||||:|:|..:||:||||||:|.||||:||
  Rat   201 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRR 265

  Fly   263 LRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMD 327
            |||||||||||||||||||||||||:||||||||:|||||||||.||||||:|||.|||||||:|
  Rat   266 LRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLD 330

  Fly   328 KGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLL 392
            ||||.:||||||||||||:|:||||||||||||||||||||||||||||||||.|||||.|||||
  Rat   331 KGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLL 395

  Fly   393 LLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLG 457
            |||||||||||||||||||.||||||||||||||.||||:|||..||:||:|||||||:|||.||
  Rat   396 LLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLG 460

  Fly   458 KFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDA 522
            ||:|:.||||||||||:||||||||||||||||.:|||||||:||||||||||||:||:|||.:|
  Rat   461 KFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEA 525

  Fly   523 EAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQLA 587
            :.|:..||..|||:.|||.:|||.:.::.|::||.|..:.|..|:..|..:..|.|.|||.||:|
  Rat   526 DGYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMA 590

  Fly   588 ERQEFEHKQQELERICSPIITRLYQGAGMAPPPTAGGSNPGATGGSGPTIEEVD 641
            |:.|:||||:||||:|:|||::||||.     |..|||:      .||||||||
  Rat   591 EKDEYEHKQKELERVCNPIISKLYQGG-----PGGGGSS------GGPTIEEVD 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	501/637 (79%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	324/376 (86%)
Hspa2	NP_068635.1	PTZ00009	2..615	CDD:240227	488/608 (80%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		329/382 (86%)
		HSPA1-2_6-8-like_NBD	7..383	CDD:212675	323/375 (86%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		98/114 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..633		14/30 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760