DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and hspa8

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001103873.1	Gene:	hspa8 / 573376	ZFINID:	ZDB-GENE-990415-92	Length:	649	Species:	Danio rerio

Alignment Length:	649	Identity:	518/649 - (79%)
Similarity:	581/649 - (89%)	Gaps:	8/649 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKLPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNN 65
            |.|.|||||||||||||||||||||||||||||||||||||||||::||||||||||||||||.|
Zfish     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65

  Fly    66 TIFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRET 130
            |:|||||||||||||..||||||||||.|..:|.:|:::||||||.|||||||:||||||||:|.
Zfish    66 TVFDAKRLIGRRFDDGVVQSDMKHWPFNVINDNSRPKVQVEYKGESKSFYPEEISSMVLTKMKEI 130

  Fly   131 AEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNV 195
            ||||||.||::||:||||||||||||||||||.|:||||||||||||||||||||||:..:||||
Zfish   131 AEAYLGKTVSNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195

  Fly   196 LIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRAL 260
            |||||||||||||:|||||||||||:|||||||||||||||:||||:.||:||||||:..||||:
Zfish   196 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFITEFKRKHKKDISDNKRAV 260

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAK 325
            |||||||||||||||||||||||||||:||:|||||:|||||||||.||||||::||.|||||||
Zfish   261 RRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAK 325

  Fly   326 MDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQD 390
            |||.||||||||||||||||:|:||||:|||||||||||||||||||||||||||.|||||.|||
Zfish   326 MDKAQIHDIVLVGGSTRIPKIQKLLQDYFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQD 390

  Fly   391 LLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNS 455
            |||||||||||||||||||||.||||||||||||||.||||:||||||||||:|||||||:|||.
Zfish   391 LLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455

  Fly   456 LGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVN 520
            ||||||:.||||||||||:|||||||||||:||:|::|||||||:|||||||||||||||||||.
Zfish   456 LGKFELTGIPPAPRGVPQIEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQ 520

  Fly   521 DAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQ 585
            :||.|:..|:.|||:::|||.||||.|.::||::||.|..:.|..|::.|..:.:|.|.|||.||
Zfish   521 EAEKYKAEDDVQRDKVSAKNGLESYAFNMKSTVEDEKLKGKISDEDKQKILDKCNEVIGWLDKNQ 585

  Fly   586 LAERQEFEHKQQELERICSPIITRLYQGAGMAP---PPTAGGSNPGA-----TGGSGPTIEEVD 641
            .|||:||||:|:|||::|:||||:|||.||..|   |....|..|||     .|.|||||||||
Zfish   586 TAEREEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPEGMPGGFPGAGAAPGGGSSGPTIEEVD 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	516/647 (80%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	324/374 (87%)
hspa8	NP_001103873.1	HSP70	1..614	CDD:331774	500/612 (82%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		330/383 (86%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		100/114 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..649		16/34 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68524
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		mtm6456
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.830