DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and hspa14

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001015780.1	Gene:	hspa14 / 548497	XenbaseID:	XB-GENE-5932856	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	171/512 - (33%)
Similarity:	289/512 - (56%)	Gaps:	20/512 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIF 68
            :.|:|:.||.|.:||.|::.|:.:::|||.|:|.||:.|.|.|.|.::|.|||.....|..|||.
Frog     1 MAAIGVHLGCTCACVAVYKDGRADVVANDAGDRVTPAVVGFLEKETIVGLAAKQSRVRNATNTIV 65

  Fly    69 DAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFY-PEEVSSMVLTKMRETAE 132
            ..|:::||.:.|...|..:......|..:.|||:..:: .||.:.|. .|:|:.::.:||:|||:
Frog    66 KVKQILGRSYGDPHTQKHISESKCIVVEKVGKPKYEID-TGETQKFVSSEDVAKLIFSKMKETAQ 129

  Fly   133 AYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQG-TSERNVL 196
            :.||..|.|.|:|||..|.:||::|..:|...||.::||:|:||:||.:|||:.::. |.:.|||
Frog   130 SALGSDVNDVVITVPFDFGESQKKALGEAATAAGFSILRMIHEPSAALLAYGIGQESPTGKSNVL 194

  Fly   197 IFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALR 261
            ::.|||.:..|:|:.:..||:.|.||:....:||..|...|..|...||||.:|:|:..|.||:.
Frog   195 VYKLGGTSLSVTVIEVNSGIYRVLATSTYDDIGGICFTEALAQHLASEFQRTYKQDIRGNARAMM 259

  Fly   262 RLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKM 326
            :|..:.:.||..||:...::..:|||::|:||..:|:|||||.:...||...::|:.|.|.....
Frog   260 KLMNSADVAKHALSTLGSSNCFVDSLYDGIDFDCNVSRARFELICSSLFNQCIDPIKKLLEQIGF 324

  Fly   327 DKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQ-D 390
            ....::.:||.|||.||||:|:|::|.|...|:..||.|||.:..|||:||.||.|.::.:.. |
Frog   325 KANDVNQVVLCGGSARIPKLQQLIKDLFPEVEMLSSIPPDEVIPVGAAIQAGILIGKENLSTDLD 389

  Fly   391 LLLLDVTPLSLGI----ETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPG----VLIQVFE-GE 446
            .:.::.:...:.:    |:.....|.|:...|.:|.::..:.     ..||    |.::::| |.
Frog   390 TITIECSASDILVKETDESGDNKFTVLLPSGTPLPARRQHVL-----QAPGHISSVCLELYESGG 449

  Fly   447 RAMTRDNNSLGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITI 503
            ::..  .:...:..|..:.....||..:.....:..:|.|::|..:|.:||...||:
Frog   450 KSPV--ESKFAQIVLKDLQKKASGVHDILTVLTMKRDGSLHITCTDKDSGKSEMITV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	171/512 (33%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	147/376 (39%)
hspa14	NP_001015780.1	HSPA14-like_NBD	2..376	CDD:212680	145/374 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910