DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and CG7182

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	147/531 - (27%)
Similarity:	244/531 - (45%)	Gaps:	89/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PAVGIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFT-ESERLIGDAAKNQVAMNPNNTI 67
            |..||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:. .||...|..||.::|..|...:
  Fly     3 PRFGIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAV 67

  Fly    68 FDAKRLI--GRRFDDATVQSDMKHWPFE------VF-AENGKPRIRVEYKGER---KSFYPEEVS 120
            ..:.:|:  .....:..:.|.::..|.:      || .|:..|..| |.:.:|   |.....:|:
  Fly    68 AHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDR-EDQDDRVVTKDLSAYQVT 131

  Fly   121 SMVLTKMRETAEAYL--GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAY 183
            ..:|....|.|..|.  |.....||:::|:|:..|..:...||...||.:|.:||.|||||.:.|
  Fly   132 VELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAVLGY 196

  Fly   184 GLDKQGTSE-RNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQR 247
            .:.::.|.: |:||....||...|::..::::|:|...||.|...:||..|...||....:||:|
  Fly   197 SIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQFICEEFRR 261

  Fly   248 KHKKDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRG 312
            |:|.|..:::|::.::|||....|..|::.....:.||||.:|||:...::|||||.|...:...
  Fly   262 KYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMSRARFESLIQPVINN 326

  Fly   313 TMEPVAKALRDAKMDK---GQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAA 374
            .::.:.:.:..|:.:.   .:|.||||:|.:.:|||:|..:...|...:|:.|.:.||.||.|.|
  Fly   327 LIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSADEVVAIGCA 391

  Fly   375 VQAAIL------------------------HG-DKSEAVQDLLLLDVTPLSLGIETAGGVMTTLI 414
            .||..|                        || |:|.|          .|.||
  Fly   392 RQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNA----------KLVLG------------ 434

  Fly   415 KRNTTIPTKQTQIFTTYADNQPGVLIQVFEGE---------RAMTRDNNSLGKFELSAIPPAPRG 470
             |.:.:|.|   |..:...::.|      :|:         :..|.::..|.:...|.||  ..|
  Fly   435 -RGSVLPAK---IRISLPQSEEG------KGDDVSKAAASFKLRTGESEILARLPDSTIP--EDG 487

  Fly   471 VPQVEVTFDID 481
            :.|:||..|:|
  Fly   488 LYQLEVEVDVD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	147/531 (28%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	121/418 (29%)
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	118/389 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840