DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and F11F1.1

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001255199.1	Gene:	F11F1.1 / 3565569	WormBaseID:	WBGene00008714	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	597	Identity:	249/597 - (41%)
Similarity:	361/597 - (60%)	Gaps:	9/597 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTE-SERLIGDAAKNQVAMNPNNTIFD 69
            ::|||||||:|||..:|:|:|.|:.|:.|.|||||.:|..| .:.|||..||:.:. ...|::||
Worm     2 SIGIDLGTTFSCVAYYQNGQVNILENENGCRTTPSVLAVGEDGDLLIGQHAKDVIG-KATNSLFD 65

  Fly    70 AKRLIGRRFDDATVQSDMKHWPFEVFA-ENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEA 133
            .||:||||:||..:|.||..|||:|.. :||.|.:.:....:...|....|||::|..::..||.
Worm    66 VKRIIGRRYDDVLLQRDMPLWPFKVEKDDNGIPYLEIHKNEKPLKFSAVTVSSLILRCLKYNAER 130

  Fly   134 YLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIF 198
            .||..|..||:|||||||.:||:||::|..||||.||||:||||||||||.|..|..|.||:||:
Worm   131 KLGLEVKSAVITVPAYFNATQRRATEEAAEIAGLKVLRILNEPTAAAIAYSLKGQRLSRRNILIY 195

  Fly   199 DLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRL 263
            |||||||||:.:.::.....|||..|||||||:|.||.::...::||:.:|..||..|.|||:|:
Worm   196 DLGGGTFDVAAVNVDGPRITVKAKGGDTHLGGQDIDNIIMIKMLEEFKNRHGIDLKGNYRALKRI 260

  Fly   264 RTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDK 328
            |.|.|.||.|||:|:.|.||::.|..|:||...::|..||....:|...|:..|.:.:|:|.:.|
Worm   261 RKAAEVAKITLSASSVARIELECLHLGIDFIMRISRTDFESWIENLLMATVIHVERVIREANLKK 325

  Fly   329 GQIHDIVLVGGSTRIPKVQRLL-QDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLL 392
            .||::|||||||||||.::.:: |.|.:...:.:||:||||||||||:.||:|.|  :|.|||:.
Worm   326 SQINEIVLVGGSTRIPILKNIIKQSFESNTRICESIHPDEAVAYGAAIMAAVLSG--AEEVQDMR 388

  Fly   393 LLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLG 457
            |:||.|:|:|::.....|:.|||:.|..|..:.:.|....|.|..:.:.|:||||.:...|..||
Worm   389 LIDVIPMSIGVQCNRDYMSVLIKKGTVFPCTKRKTFINSDDFQTSINVPVYEGERVLCSHNRQLG 453

  Fly   458 KFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDA 522
            :..| .|.|..||...|::|.::|.||||..|||:.:|.|....||..|....::.:|:.|.:.:
Worm   454 EISL-PIQPKRRGESVVDITLEVDYNGILQATALDLNTKKAITTTILYDCCTYTQPEIDEMTSQS 517

  Fly   523 EAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQLA 587
            |..|..||..:.|.....:.|...:..:..|  |.:.....|.....:.:.....|:||......
Worm   518 EEDRIFDEHFKMRYKQLQKSEDMAYGYKHRL--EKVKGSVEPGKFSNLMETVEREISWLSVFPKV 580

  Fly   588 ERQEFEHKQQEL 599
            ...|:..:::.|
Worm   581 SPNEYMQRRRAL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	249/597 (42%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	184/377 (49%)
F11F1.1	NP_001255199.1	HSP70	3..598	CDD:365808	249/596 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910