Protein Alignment Hsc70-1 and HSPA6

DIOPT Version :9

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_002146.2
• Gene: HSPA6 / 3310
• HGNCID: 5239
• Length: 643
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 488/645 - (75%)
• Similarity: 563/645 - (87%)
• Gaps: 10/645 - (1%)

  Fly     2 PKLPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNT 66
            |:..|||||||||||||||||.|:|||:||||||||||||||||::|||:|||||:|.|:||:||
Human     4 PRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNT 68

  Fly    67 IFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETA 131
            :|||||||||:|.|.|||||||||||.|.:|.|||::||.|:||.|:|||||:|||||:||:|||
Human    69 VFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETA 133

  Fly   132 EAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVL 196
            |||||..|..||:||||||||||||||||||||||||||||||||||||||||||::|..|||||
Human   134 EAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVL 198

  Fly   197 IFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALR 261
            ||||||||||||||:|:.|:|||||||||||||||||||||||||::||:|||.|||..||||||
Human   199 IFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALR 263

  Fly   262 RLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKM 326
            |||||||||||||||||||::||||||||||||||:||||||||..||||.|:|||.|||||||:
Human   264 RLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKL 328

  Fly   327 DKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDL 391
            ||.||||:|||||||||||||:||||||||||||||||||||||||||||||:|.|||.|.||||
Human   329 DKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDL 393

  Fly   392 LLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSL 456
            |||||.|||||:|||||||||||:||.||||||||.||||:||||||.|||:|||||||:|||.|
Human   394 LLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLL 458

  Fly   457 GKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVND 521
            |:||||.||||||||||:||||||||||||:|||.::||||.|:|||||||||||||::||||::
Human   459 GRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHE 523

  Fly   522 AEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQL 586
            ||.|:..||.||||:.|||.||::.|.::.:|.:|.|..:....||..:|.:..|.:|||:.|||
Human   524 AEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQL 588

  Fly   587 AERQEFEHKQQELERICSPIITRLYQGAGMAPPPTAGGSNPGATG-----GSGPTIEEVD 641
            ||::|:||:::|||:||.||.:|||.|.|:     .|||:.|...     .:||.|||||
Human   589 AEKEEYEHQKRELEQICRPIFSRLYGGPGV-----PGGSSCGTQARQGDPSTGPIIEEVD 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	486/643 (76%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	315/374 (84%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		320/383 (84%)
		HSP70	8..643	CDD:331774	485/639 (76%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		95/114 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..643		10/31 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S49
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680