DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-1 and HSPA5

DIOPT Version :10

Sequence 1:NP_524063.1 Gene:Hsc70-1 / 39542 FlyBaseID:FBgn0001216 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_005338.1 Gene:HSPA5 / 3309 HGNCID:5238 Length:654 Species:Homo sapiens


Alignment Length:618 Identity:390/618 - (63%)
Similarity:501/618 - (81%) Gaps:8/618 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-ESERLIGDAAKNQVAMNPNNTIFDA 70
            |||||||||||||||::|:|||||||||||.|||||||| |.|||||||||||:..||.||:|||
Human    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEY-KGERKSFYPEEVSSMVLTKMRETAEAY 134
            ||||||.::|.:||.|:|..||:|..:..||.|:|:. .|:.|:|.|||:|:||||||:||||||
Human    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160

  Fly   135 LGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFD 199
            ||..||.|||||||||||:|||||||||.||||||:|||||||||||||||||: ..|:|:|:||
Human   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 224

  Fly   200 LGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLR 264
            |||||||||:|||::|:|||.||.|||||||||||.|::.||::.:::|..||:.::.||:::||
Human   225 LGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLR 289

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKG 329
            ...|:|||.|||..||.|||:|.:||.||..::|||:|||||.||||.||:||.|.|.|:.:.|.
Human   290 REVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKS 354

  Fly   330 QIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLL 394
            .|.:||||||||||||:|:|:::||||||.::.|||||||||||||||.:|.||:...  ||:||
Human   355 DIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTG--DLVLL 417

  Fly   395 DVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKF 459
            ||.||:|||||.|||||.||.|||.:|||::|||:|.:||||.|.|:|:||||.:|:||:.||.|
Human   418 DVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTF 482

  Fly   460 ELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEA 524
            :|:.||||||||||:||||:||.||||.|||.:|.||.:|:||||||:.||:.|:|||||||||.
Human   483 DLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEK 547

  Fly   525 YRQADEQQRDRINAKNQLESYCFQLRSTL-DDEHLSSRFSPADRETIQQRSSETIAWLDANQLAE 588
            :.:.|::.::||:.:|:||||.:.|::.: |.|.|..:.|..|:||:::...|.|.||:::|.|:
Human   548 FAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDAD 612

  Fly   589 RQEFEHKQQELERICSPIITRLYQGAGMAPPPT 621
            .::|:.|::|||.|..|||::||..||  ||||
Human   613 IEDFKAKKKELEEIVQPIISKLYGSAG--PPPT 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-1NP_524063.1 PTZ00009 1..641 CDD:240227 390/618 (63%)
HSPA5NP_005338.1 Required for interaction with ELAPOR1. /evidence=ECO:0000269|PubMed:26045166 1..80 42/48 (88%)
HSP70 30..635 CDD:394970 382/606 (63%)
Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 125..280 110/155 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 4/11 (36%)
Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 420..500 53/79 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..654 8/13 (62%)
Prevents secretion from ER. /evidence=ECO:0000255 651..654
Blue background indicates that the domain is not in the aligned region.

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