DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-1 and HSPA2

DIOPT Version :9

Sequence 1:NP_524063.1 Gene:Hsc70-1 / 39542 FlyBaseID:FBgn0001216 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_001374860.1 Gene:HSPA2 / 3306 HGNCID:5235 Length:639 Species:Homo sapiens


Alignment Length:639 Identity:507/639 - (79%)
Similarity:571/639 - (89%) Gaps:7/639 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFD 69
            ||:||||||||||||||||||||||||||||||||||||||::||||||||||||||||.|||||
Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    70 AKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAY 134
            |||||||:|:|||||||||||||.|.:|.|||:::||||||.|:|:|||:||||||||:|.||||
Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   135 LGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTS--ERNVLI 197
            |||.|..||:||||||||||||||||||.|.||||||||||||||||||||||:|.:  |:||||
Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   198 FDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRR 262
            |||||||||||:|||||||||||:|||||||||||||||:|:|..:||:||||||:|.||||:||
Human   201 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRR 265

  Fly   263 LRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMD 327
            |||||||||||||||||||||||||:||||||||:|||||||||.||||||:|||.|||||||:|
Human   266 LRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLD 330

  Fly   328 KGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLL 392
            ||||.:||||||||||||:|:||||||||||||||||||||||||||||||||.|||||.|||||
Human   331 KGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLL 395

  Fly   393 LLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLG 457
            |||||||||||||||||||.||||||||||||||.||||:|||..||:||:|||||||:|||.||
Human   396 LLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLG 460

  Fly   458 KFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDA 522
            ||:|:.||||||||||:||||||||||||||||.:|||||||:||||||||||||:||:|||.:|
Human   461 KFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEA 525

  Fly   523 EAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQLA 587
            |.|:..||..|||:.|||.||||.:.::.|::||.|..:.|..|:..|..:..|.|.|||.||:|
Human   526 ERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMA 590

  Fly   588 ERQEFEHKQQELERICSPIITRLYQGAGMAPPPTAGGSNPGATGGSGPTIEEVD 641
            |:.|:||||:||||:|:|||::||||   .|...:||...||:|  ||||||||
Human   591 EKDEYEHKQKELERVCNPIISKLYQG---GPGGGSGGGGSGASG--GPTIEEVD 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-1NP_524063.1 PTZ00009 1..641 CDD:240227 505/637 (79%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 324/376 (86%)
HSPA2NP_001374860.1 PTZ00009 2..615 CDD:240227 490/608 (81%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..389 329/382 (86%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 397..512 98/114 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..639 16/30 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142564
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 1 1.000 - - otm40336
orthoMCL 1 0.900 - - OOG6_100083
Panther 1 1.100 - - O PTHR19375
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X148
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.760

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