Protein Alignment Hsc70-1 and HSPA2

DIOPT Version :10

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 507/639 - (79%)
• Similarity: 571/639 - (89%)
• Gaps: 7/639 - (1%)

  Fly     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFD 69
            ||:||||||||||||||||||||||||||||||||||||||::||||||||||||||||.|||||
Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    70 AKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAY 134
            |||||||:|:|||||||||||||.|.:|.|||:::||||||.|:|:|||:||||||||:|.||||
Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   135 LGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTS--ERNVLI 197
            |||.|..||:||||||||||||||||||.|.||||||||||||||||||||||:|.:  |:||||
Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   198 FDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRR 262
            |||||||||||:|||||||||||:|||||||||||||||:|:|..:||:||||||:|.||||:||
Human   201 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRR 265

  Fly   263 LRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMD 327
            |||||||||||||||||||||||||:||||||||:|||||||||.||||||:|||.|||||||:|
Human   266 LRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLD 330

  Fly   328 KGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLL 392
            ||||.:||||||||||||:|:||||||||||||||||||||||||||||||||.|||||.|||||
Human   331 KGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLL 395

  Fly   393 LLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLG 457
            |||||||||||||||||||.||||||||||||||.||||:|||..||:||:|||||||:|||.||
Human   396 LLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLG 460

  Fly   458 KFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDA 522
            ||:|:.||||||||||:||||||||||||||||.:|||||||:||||||||||||:||:|||.:|
Human   461 KFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEA 525

  Fly   523 EAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQLA 587
            |.|:..||..|||:.|||.||||.:.::.|::||.|..:.|..|:..|..:..|.|.|||.||:|
Human   526 ERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMA 590

  Fly   588 ERQEFEHKQQELERICSPIITRLYQGAGMAPPPTAGGSNPGATGGSGPTIEEVD 641
            |:.|:||||:||||:|:|||::||||   .|...:||...||:|  ||||||||
Human   591 EKDEYEHKQKELERVCNPIISKLYQG---GPGGGSGGGGSGASG--GPTIEEVD 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	505/637 (79%)
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	490/608 (81%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		329/382 (86%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		98/114 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		16/30 (53%)