Protein Alignment Hsc70-1 and HSPA1L

DIOPT Version :10

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 499/636 - (78%)
• Similarity: 569/636 - (89%)
• Gaps: 2/636 - (0%)

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDA 70
            |:||||||||||||||||||||||||||||||||||||||::||||||||||||||||.||:|||
Human     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYL 135
            ||||||:|:|..||:|||.|||:|..|.|||::.|.||||.|:|||||:|||||||::|||||:|
Human    73 KRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137

  Fly   136 GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFDL 200
            |..||:||:||||||||||||||||||.||||||||||||||||||||||||.|..||:||||||
Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDL 202

  Fly   201 GGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRT 265
            ||||||||:|||:|||||||||||||||||||||||||:|||:||:||||||:.|||||:|||||
Human   203 GGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRT 267

  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQ 330
            |||||||||||||||::|||||:||:|||||:||||||||..||||||:|||.||||||||||.:
Human   268 ACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKAK 332

  Fly   331 IHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLD 395
            ||||||||||||||||||||||:|||::||||||||||||||||||||||.|||||.||||||||
Human   333 IHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLD 397

  Fly   396 VTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFE 460
            |.|||||:||||||||.|||||:|||||||||||||:||||||||||:|||||||:|||.||:|:
Human   398 VAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFD 462

  Fly   461 LSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEAY 525
            |:.||||||||||:||||||||||||||||.:|||||.|:|||||||||||||:|||||.|||.|
Human   463 LTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEKY 527

  Fly   526 RQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQLAERQ 590
            :..||.||::|.|||.||||.|.::|.:.||.|..:.|.:|:..|..:.:|.::||:.|||||:.
Human   528 KAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEKD 592

  Fly   591 EFEHKQQELERICSPIITRLYQGAGMAPPPTAGGSNPGATGGSGPTIEEVD 641
            ||:||::|||::|:||||:|||| |...|....|..||.. .:||||||||
Human   593 EFDHKRKELEQMCNPIITKLYQG-GCTGPACGTGYVPGRP-ATGPTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	497/634 (78%)
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		322/379 (85%)
		PTZ00009	4..641	CDD:240227	497/634 (78%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		97/114 (85%)