Protein Alignment Hsc70-1 and HSPA1A

DIOPT Version :10

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_005336.3
• Gene: HSPA1A / 3303
• HGNCID: 5232
• Length: 641
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 507/641 - (79%)
• Similarity: 571/641 - (89%)
• Gaps: 0/641 - (0%)

  Fly     1 MPKLPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNN 65
            |.|..|:||||||||||||||||||||||||||||||||||||||::|||||||||||||:||.|
Human     1 MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQN 65

  Fly    66 TIFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRET 130
            |:|||||||||:|.|..||||||||||:|..:..||:::|.||||.|:|||||:||||||||:|.
Human    66 TVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEI 130

  Fly   131 AEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNV 195
            ||||||..||:||:||||||||||||||||||.|||||||||||||||||||||||:.|..||||
Human   131 AEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNV 195

  Fly   196 LIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRAL 260
            |||||||||||||:|||:|||||||||||||||||||||||||||||:||:||||||:.|||||:
Human   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAV 260

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAK 325
            |||||||||||||||||||||:||||||||:|||||:||||||||..||||.|:|||.|||||||
Human   261 RRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAK 325

  Fly   326 MDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQD 390
            :||.||||:|||||||||||||:||||||||::||||||||||||||||||||||.|||||.|||
Human   326 LDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQD 390

  Fly   391 LLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNS 455
            ||||||.|||||:||||||||.|||||:|||||||||||||:||||||||||:|||||||:|||.
Human   391 LLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNL 455

  Fly   456 LGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVN 520
            ||:||||.||||||||||:||||||||||||||||.:|||||.|:|||||||||||||:|||||.
Human   456 LGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQ 520

  Fly   521 DAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQ 585
            :||.|:..||.||:|::|||.||||.|.::|.::||.|..:.|.||::.:..:..|.|:|||||.
Human   521 EAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANT 585

  Fly   586 LAERQEFEHKQQELERICSPIITRLYQGAGMAPPPTAGGSNPGATGGSGPTIEEVD 641
            |||:.|||||::|||::|:|||:.||||||...|...|...|....||||||||||
Human   586 LAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	505/639 (79%)
HSPA1A	NP_005336.3	PTZ00009	1..611	CDD:240227	488/609 (80%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		324/383 (85%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		99/114 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..641		13/26 (50%)