DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and CG2918

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001162645.1	Gene:	CG2918 / 31215	FlyBaseID:	FBgn0023529	Length:	923	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	175/743 - (23%)
Similarity:	310/743 - (41%)	Gaps:	150/743 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDA 70
            :.:|||:.:..|||...| .:||..|.:..|.||:.:||.:..|.||:.|:.....:||:.....
  Fly    23 MSVDLGSEWMKVGVVSPGVPMEIALNRESKRKTPAILAFRDGTRTIGEDAQTIGIKDPNSAYGYL 87

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYL 135
            ..|:|:..|:..|....|.:|:.....:.:....|..|.:...|..||:.:.:|.|.::.|:..:
  Fly    88 LDLLGKTIDNPIVDLYRKRFPYYNIVGDPERNTVVFRKSDTDEFSVEELVAQLLVKAKQFAQESV 152

  Fly   136 GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQG---TSERNVLI 197
            ...:|:.|:|||.||..::|:|...|..:|.|.||::||:..|.|:.||:..:|   .:.:..|.
  Fly   153 QQPITECVLTVPGYFGQAEREALLSAAQLANLKVLQLINDYAAVALNYGVFHRGEINETAQYFLF 217

  Fly   198 FDLGGGTFDVSVLTIE----------DGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQ--RKHK 250
            :|:|......:|::.:          :.:.:|.....|..|||.:...||.::..|||.  :|.|
  Fly   218 YDMGAYKTSAAVVSYQLVKDKQTREINPVVQVLGVGYDRTLGGLEIQLRLRDYLAQEFNALKKTK 282

  Fly   251 KDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTME 315
            .|:..:.|||.:|.....|.|..||::|:...:|::|.|.:||...|||.:.|:|..||:....:
  Fly   283 TDVTTSPRALAKLFKEAGRLKNVLSANTEFFAQIENLIEDIDFKLPVTREKLEQLCEDLWPRATK 347

  Fly   316 PVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAIL 380
            |:.:||..:.:....|:.::|.||.||:|:||..::.... :||.|::|.||:...||..:||.|
  Fly   348 PLEEALASSHLSLDVINQVILFGGGTRVPRVQETIKAVIK-QELGKNLNADESATMGAVYKAADL 411

  Fly   381 HGD---KSEAVQDLLLLDVTPLSLGIETAGG-------VMTTLIKRNTTIPTKQT---------- 425
            ...   |...|:|..|.   ||.:..|...|       |...|.......|.|:.
  Fly   412 SAGFKVKKFVVKDATLF---PLQVSFERDPGDGAAVKQVKRALFALMNPYPQKKVITFNKHTDDF 473

  Fly   426 QIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFELSAIPPA----------PRGVPQVEVTFDI 480
            :.:..|||      :..:..|......:.::.|.:|..:...          .:|   ::..|.:
  Fly   474 EFYVNYAD------LDRYSKEEIAALGSLNVTKVQLKQVKELLEKSKKELVDNKG---IKAYFYL 529

  Fly   481 DANGILNVTALE---------------------------------------------KSTGKENR 500
            |.:||...|.:|                                             .:.|:|..
  Fly   530 DDSGIFRCTGVEYVYEKQKPEDDADEDSTLSKFGSTLSKLFTKEGEEKKDNSEQEEAANAGEEPS 594

  Fly   501 ITITNDKGR---LSKE--DIERMVNDAE------------------------------AYRQA-- 528
            .:..|:|.:   .|||  ..|....|.|                              ||.|:
  Fly   595 KSEDNEKAKEEDASKEQKSEESTKQDTEAKNETIKLVTVKSPVTYESQTQFVVPLVGSAYDQSVA 659

  Fly   529 -------DEQQRDRI-NAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQ 585
                   .|:||.|: :|.|.||::..:::..||:|..:...:..::|.:....|....||..:.
  Fly   660 KLAAINKAEEQRVRLESAFNALEAHIIEVQQKLDEESYAKCATAEEKEKLLAECSTLGEWLYEDL 724

  Fly   586 LAERQE-FEHKQQELERICSPIITRLYQ 612
            ...:.| :|.|..:|:::.:..:.|.::
  Fly   725 EDPKAEIYEEKLAQLKKLSNVFLARHWE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	175/743 (24%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	116/389 (30%)
CG2918	NP_001162645.1	HSP70	22..625	CDD:278441	152/614 (25%)
		HYOU1-like_NBD	23..409	CDD:212672	114/386 (30%)
		TAF4	<572..>627	CDD:296797	10/54 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740