DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and Hspa12b

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001381945.1	Gene:	Hspa12b / 311427	RGDID:	1312004	Length:	685	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	137/645 - (21%)
Similarity:	232/645 - (35%)	Gaps:	175/645 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEII-------ANDQG--NRTTPSYVAFTESE--RLIGDAAKNQV- 59
            |.||.|||.|..........|.|       ..|.|  ::.||:.:..|...  ...|..|::..
  Rat    63 VAIDFGTTSSGYAFSFATDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGIFHSFGYTARDYYH 127

  Fly    60 AMNPNNT----IFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVS 120
            .::|...    .|:..::......|.|:::.::       |.|||..:.:|.......|:.|.
  Rat   128 DLDPEEARDWLYFEKFKMKIHSATDLTLKTQLE-------AVNGKKMLALEVFAHALRFFKEH-- 183

  Fly   121 SMVLTKMRETAEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGL------NVLRIINEPTAA 179
              .|.::||.:|..|.......|:||||.:....:|..::|..:|||      ..|.|..||.||
  Rat   184 --ALQELREQSECMLEKDAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALEPEAA 246

  Fly   180 AI-----------------AYG-----------------------------LDKQGTSE------ 192
            ::                 |.|                             |.:.|..|
  Rat   247 SVYCRKLRLHQLMDLSSRTAGGGRLGERRSIDSSFRHAREQLRRSRHSRTFLVESGVGELWSEMQ 311

  Fly   193 --RNVLIFDLGGGTFDVSVLTIED--GIFE--VKATAGDTHLGGED--FDNRLVNHFVQEFQRKH 249
              ...::.|.||||.|::|..:|.  |..:  .||:.|.....|.|  |:..|...|.::|..|.
  Rat   312 EGDRYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIAKF 376

  Fly   250 KKDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFY---------TSVTRARFE-- 303
            |:   |...|...|..|.|..|||.......::.|...|..:|||         |::.|:...
  Rat   377 KR---QRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNFV 438

  Fly   304 ------------ELNGDLFRGTMEPVAKALRD--AKMDKGQIHDIVLVGGSTRIPKVQRLLQDFF 354
                        |...:||:.|:..:.:.:..  ||.:...:..:.||||......:|..:|:..
  Rat   439 KWSSQGMLRMSCEAMNELFQPTVSGIIQHIEMLLAKPEVQGVKLLFLVGGFAESAVLQHAVQEAL 503

  Fly   355 NGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDVTPLSLGIETAGGVMTTLI----- 414
            ..:.|...:..|..:   ..::.|:|.|.....|:    :..:||:.|:    ||:...:
  Rat   504 GNRGLRVVVPHDVGL---TILKGAVLFGQAPGVVR----VRRSPLTYGV----GVLNRFVPGHHP 557

  Fly   415 ---------KRNTT------IPTKQT-----QIFTTYADNQPG---VLIQVF----EGERAMTRD 452
                     :|..|      :..:|:     ::..:|...:||   |||.::    |..|.:|
  Rat   558 PEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFIT-- 620

  Fly   453 NNSLGKFELSAIPPAPRGVPQVEVTF----DIDA-----NGILNVTALEKSTGKENRITI 503
            :..:.|....::...|.|.|:...|.    :|.|     :..:.|||::.||.:..|..|
  Rat   621 DPGVRKCGALSLELEPEGSPENTGTSPSRREIRAAMQFGDTEIKVTAVDVSTNRSVRAAI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	137/645 (21%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	103/480 (21%)
Hspa12b	NP_001381945.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810