Protein Alignment Hsc70-1 and Hspa9

DIOPT Version :9

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001094128.2
• Gene: Hspa9 / 291671
• RGDID: 1311806
• Length: 679
• Species: Rattus norvegicus
• Alignment Length: 591
• Identity: 309/591 - (52%)
• Similarity: 405/591 - (68%)
• Gaps: 37/591 - (6%)

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-ESERLIGDAAKNQVAMNPNNTIFDA 70
            ||||||||.|||.|.:..:.:::.|.:|.|||||.|||| :.|||:|..||.|...|||||.:..
  Rat    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTPDGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVF-AENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAY 134
            |||||||:||..||.|.|:.||::. |.||.  ..||..|  |.:.|.::.:.||.||:||||.|
  Rat   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNGD--AWVEAHG--KLYSPSQIGAFVLMKMKETAENY 181

  Fly   135 LGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFD 199
            ||.|..:||:||||||||||||||||||.|:||||||:||||||||:||||||  :.::.:.::|
  Rat   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDK--SEDKVIAVYD 244

  Fly   200 LGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLR 264
            |||||||:|:|.|:.|:||||:|.|||.|||||||..|:.|.|:||:|:...||.::..||:|:|
  Rat   245 LGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVR 309

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGVD----FYTSVTRARFEELNGDLFRGTMEPVAKALRDAK 325
            .|.|:||..||||.|..|.:..|.....    ....:|||:||.:..||.:.|:.|..||::||:
  Rat   310 EAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQDAE 374

  Fly   326 MDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQD 390
            :.|..|.:::||||.||:||||:.:||.| |:..:|::|||||||.|||:|..:|.||    |.|
  Rat   375 VSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----VTD 434

  Fly   391 LLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNS 455
            :||||||||||||||.|||.|.||.||||||||::|:|:|.||.|..|.|:|.:|||.|..||..
  Rat   435 VLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKL 499

  Fly   456 LGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVN 520
            ||:|.|..||||||||||:|||||||||||::|:|.:|.||:|.:|.| ...|.|||:|||.||.
  Rat   500 LGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI-QSSGGLSKDDIENMVK 563

  Fly   521 DAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDD--EHLSSRFSPAD------------RETIQ 571
            :||.|.:.|.::::|:.|.|..|.......:.:::  :.|     |||            ||.:.
  Rat   564 NAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQL-----PADECNKLKEEISKMRELLA 623

  Fly   572 QRSSET 577
            ::.|||
  Rat   624 RKDSET 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	309/591 (52%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	202/379 (53%)
Hspa9	NP_001094128.2	Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646	1..432		205/386 (53%)
		dnaK	52..656	CDD:234715	309/591 (52%)
		HSPA9-like_NBD	52..428	CDD:212683	202/378 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646	432..679		104/204 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..679

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820