DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and SLC9C2

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_011507728.1	Gene:	SLC9C2 / 284525	HGNCID:	28664	Length:	1129	Species:	Homo sapiens

Alignment Length:	142	Identity:	30/142 - (21%)
Similarity:	58/142 - (40%)	Gaps:	40/142 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 ILHGDKSEAVQDLLLL-----DVTPLSLGIETAGGVMTTLIK--RNTTIPTKQTQIFTTYADNQP 436
            ||..:|.:||::|:|:     ||.   :.::|...:...:.|  :|.|....:
Human   776 ILETNKQDAVKELVLMEHEGRDVV---IALKTKQAIRNVIAKALKNLTFLCSR------------ 825

  Fly   437 GVL--IQVFEGERAMTRDNNSLGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKEN 499
            |::  .:|.|..:.:.:...:|..|..:..||.|          ||..:   |:..||   ||:.
Human   826 GIIDKHEVIEINKVLLKKLKALNNFPKAIPPPTP----------DIYLH---NIIWLE---GKDV 874

  Fly   500 RITITNDKGRLS 511
            .|....::.:|:
Human   875 LIDFFKERAKLA 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	30/142 (21%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	1/1 (100%)
SLC9C2	XP_011507728.1	Na_H_Exchanger	98..380	CDD:294713
		Ion_trans	638..>731	CDD:278921
		CAP_ED	873..980	CDD:237999	2/14 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900