DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-1 and Hspa4

DIOPT Version :9

Sequence 1:NP_524063.1 Gene:Hsc70-1 / 39542 FlyBaseID:FBgn0001216 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_705893.1 Gene:Hspa4 / 266759 RGDID:628878 Length:840 Species:Rattus norvegicus


Alignment Length:824 Identity:217/824 - (26%)
Similarity:357/824 - (43%) Gaps:209/824 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIF 68
            :..||||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.:|.|||:||..|..||:.
  Rat     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQ 65

  Fly    69 DAKRLIGRRFDDATVQSDMKHWPFEVF-AENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAE 132
            ..||..||.|.|..|:::..:..:::. ...|...|:|.|..|.::|..|:|::|:|:|::||||
  Rat    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   133 AYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQG-----TSE 192
            :.|...|.|.||:||:::.|::|::..||..|||||.||::||.||.|:|||:.||.     ...
  Rat   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   193 RNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNK 257
            |||:..|:|...:.|||.....|..:|.|||.||.|||..||..|||||.:||.:|:|.|:....
  Rat   196 RNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKV 260

  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKAL 321
            |||.||...||:.|:.:| :::...:.|:.....:|...::.|.:|.|:..||......|:...|
  Rat   261 RALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSIL 325

  Fly   322 RDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSE 386
            ..:|:.|..|:.:.:|||:||||.|:..:..|| ||||:.::|.||||..|.|:|.|||  ..:.
  Rat   326 DQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAIL--SPAF 387

  Fly   387 AVQDLLLLDVTPLSLGIE-----TAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGE 446
            .|::..:.||.|..:.:.     ..|.....:..:|...|.  :::.|.|. .:|..|...:...
  Rat   388 KVREFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPF--SKVLTFYR-KEPFTLEAYYSSP 449

  Fly   447 RAMTRDNNSLGKFELSAIPPAPRG-VPQVEVTFDIDANGILNVTA---LEKSTGKENRITITNDK 507
            :.:...:.::.:|.:..:.|...| ..:|:|...::.:||.:|::   :|....:|:...:..|:
  Rat   450 QDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQ 514

  Fly   508 GRLSKEDIERMVNDAEAYRQ--------------------------------------------- 527
            .  :||:.:..|:..|.:.:                                             
  Rat   515 N--AKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTV 577

  Fly   528 -----------------------------ADEQQRDRINAKNQLESYCFQLRSTLDDEH------ 557
                                         .|:.:::|.:|||.:|.|.:::|..|..|:      
  Rat   578 DLPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSE 642

  Fly   558 ------------------------------------------LSSRF------------------ 562
                                                      :.:||                  
  Rat   643 DDRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQ 707

  Fly   563 -------------------SPADRETIQQRSSETIAW------------LDANQLAERQEFEHKQ 596
                               ..||...:::.::|.:.|            |.|:.:.:.:|.|.|.
  Rat   708 QYMKVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKI 772

  Fly   597 QELERICSPIITRLYQGAGMAPP-----------PTAG-GSNPG 628
            :||..||||||::  ....:.||           |..| |.|||
  Rat   773 KELTNICSPIISK--PKPKVEPPKEEPKHAEQNGPVDGQGDNPG 814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-1NP_524063.1 PTZ00009 1..641 CDD:240227 217/824 (26%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 153/381 (40%)
Hspa4NP_705893.1 HSPA4_NBD 2..384 CDD:212687 154/384 (40%)
PTZ00121 <499..743 CDD:173412 22/245 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..575 6/76 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 781..840 11/36 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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