DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and HSPA12A

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001317093.1	Gene:	HSPA12A / 259217	HGNCID:	19022	Length:	692	Species:	Homo sapiens

Alignment Length:	671	Identity:	141/671 - (21%)
Similarity:	233/671 - (34%)	Gaps:	227/671 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPAVGIDLGTTYS-----------CVGVFQHGKVEIIANDQG--NRTTPSYVAFTESERL--IGD 53
            |..|.:|.|||.|           |:.|.:..:    ..|.|  |:.||:.:..|...:.  .|.
Human    73 LVVVAVDFGTTSSGYAYSFTKEPECIHVMRRWE----GGDPGVSNQKTPTTILLTPERKFHSFGY 133

  Fly    54 AAKN-QVAMNPNNTIFDAKR-LIGRRF-------DDATVQSDMKHWPFEVFAENGKPRIRVEYKG 109
            ||:: ...::||    :||: |...:|       .|.|:.:|:.       |.|||....:|...
Human   134 AARDFYHDLDPN----EAKQWLYLEKFKMKLHTTGDLTMDTDLT-------AANGKKVKALEIFA 187

  Fly   110 ERKSFYPEEVSSMVLTKMRETAEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGL------N 168
            ....::.|:    .|.::.:.|.:....:....|:||||.:....:|..:.|...|||      .
Human   188 YALQYFKEQ----ALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASPENSE 248

  Fly   169 VLRIINEPTAAAI--------------------AY-GLDKQGTS--------ERN---------- 194
            .|.|..||.||:|                    .| |.|..|..        .||
Human   249 QLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLVEN 313

  Fly   195 --------------VLIFDLGGGTFDVSV--LTIEDGIFE--VKATAGDTHLGGEDFD-NRLV-- 238
                          .::.|.||||.|::|  :.:.:|..:  .|||.|.....|.|:: .:|:
Human   314 VIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLYK 378

  Fly   239 ---NHFVQEFQRKHKKDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYT----- 295
               ..|:::|:.|       ...|...|..|.|..||..:......:.|...|..:|:|.
Human   379 IFGEDFIEQFKIK-------RPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGH 436

  Fly   296 SVTRARFEELNGD-------------------LFRGTMEPVAKALRD--AKMDKGQIHDIVLVGG 339
            ||..| ..:.|.|                   ||:.|::.:.:.|||  .|.:...:..:.||||
Human   437 SVEHA-LRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGG 500

  Fly   340 STRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDV--TPLSLG 402
            ....|.:|:.:|..| |.:....|..|..:   ..::.|:|.|      .|..::.|  :||:.|
Human   501 FAEAPLLQQAVQAAF-GDQCRIIIPQDVGL---TILKGAVLFG------LDPAVIKVRRSPLTYG 555

  Fly   403 IETAGGVMT--------------------------------------TLIKRNTTIPTKQTQIFT 429
            :    ||:.                                      .|:||:.| |.|.:|:.
Human   556 V----GVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYT-PAKPSQLV- 614

  Fly   430 TYADNQPGVLIQVFEGERAMTRDNNSL---------GKFELSAIPPAPRGVP---QVEVTFDIDA 482
                    ::|.::..|    .||.|.         |...|.....:...||   :::.......
Human   615 --------IVINIYSSE----HDNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREIQTLMQFGD 667

  Fly   483 NGILNVTALEKSTGKENRITI 503
            ..| ..||::.:|.|..::.|
Human   668 TEI-KATAIDIATSKSVKVGI 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	141/671 (21%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	109/493 (22%)
HSPA12A	NP_001317093.1	HSPA12A_like_NBD	74..540	CDD:212685	111/502 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810