DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and bip1

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_593245.1	Gene:	bip1 / 2541815	PomBaseID:	SPAC22A12.15c	Length:	663	Species:	Schizosaccharomyces pombe

Alignment Length:	615	Identity:	359/615 - (58%)
Similarity:	479/615 - (77%)	Gaps:	8/615 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDAK 71
            :|||||||||||.|.::|:|||||||||||.|||||||||.|||:|:|||||...||.|||||.|
pombe    38 IGIDLGTTYSCVAVMKNGRVEIIANDQGNRITPSYVAFTEDERLVGEAAKNQAPSNPENTIFDIK 102

  Fly    72 RLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYLG 136
            |||||:||:.|:..|:|.:||.:..:..:|.:.|...|::|.|.|||:|:|:|:||::|||||||
pombe   103 RLIGRKFDEKTMAKDIKSFPFHIVNDKNRPLVEVNVGGKKKKFTPEEISAMILSKMKQTAEAYLG 167

  Fly   137 GTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFDLG 201
            ..||.|||||||||||:|||||||||.||||||:||:||||||||||||||..| |::::::|||
pombe   168 KPVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVIRIVNEPTAAAIAYGLDKTDT-EKHIVVYDLG 231

  Fly   202 GGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRTA 266
            |||||||:|:|::|:|||.||:|||||||||||||::|:..:.:.||:..|:.::.:|:.:|:..
pombe   232 GGTFDVSLLSIDNGVFEVLATSGDTHLGGEDFDNRVINYLARTYNRKNNVDVTKDLKAMGKLKRE 296

  Fly   267 CERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQI 331
            .|:|||||||.....|||:|.|.|.||..:::||:|||:|.|||:.|::||.:.|:|:.:.|.:|
pombe   297 VEKAKRTLSSQKSVRIEIESFFNGQDFSETLSRAKFEEINMDLFKKTLKPVEQVLKDSNLKKSEI 361

  Fly   332 HDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDV 396
            .|||||||||||||||.||:.|| ||:.:|.|||||||||||||||.:|.|:  |...:::||||
pombe   362 DDIVLVGGSTRIPKVQELLESFF-GKKASKGINPDEAVAYGAAVQAGVLSGE--EGSDNIVLLDV 423

  Fly   397 TPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFEL 461
            .||:|||||.|||||.||.|||.|||:::|||:|..|||..|||||:||||.:|:|||.||||:|
pombe   424 IPLTLGIETTGGVMTKLIGRNTPIPTRKSQIFSTAVDNQNTVLIQVYEGERTLTKDNNLLGKFDL 488

  Fly   462 SAIPPAPRGVPQVEVTFDIDANGILNVTALEKS-TGKENRITITNDKGRLSKEDIERMVNDAEAY 525
            ..||||||||||:||||::||||:|.|:|::|| .||..::.|.|||||||:|||||||.:||.:
pombe   489 RGIPPAPRGVPQIEVTFEVDANGVLTVSAVDKSGKGKPEKLVIKNDKGRLSEEDIERMVKEAEEF 553

  Fly   526 RQADEQQRDRINAKNQLESYCFQLRSTL-DDEHLSSRFSPADRETIQQRSSETIAWLDAN-QLAE 588
            .:.|:..::||.|:|.||:|.:.|:... |||.|..:..|.|::.:.....:...||:.: :.|.
pombe   554 AEEDKILKERIEARNTLENYAYSLKGQFDDDEQLGGKVDPEDKQAVLDAVEDVAEWLEIHGEDAS 618

  Fly   589 RQEFEHKQQELERICSPIITRLY-QGAGMA 617
            ::|||.::|:|:.:..||..:|| :|||.|
pombe   619 KEEFEDQRQKLDAVVHPITQKLYSEGAGDA 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	359/615 (58%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	234/373 (63%)
bip1	NP_593245.1	HSPA5-like_NBD	35..407	CDD:212681	233/370 (63%)
bip1	NP_593245.1	HSP70	37..641	CDD:278441	353/606 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720