DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and sks2

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_595438.1	Gene:	sks2 / 2540199	PomBaseID:	SPBC1709.05	Length:	613	Species:	Schizosaccharomyces pombe

Alignment Length:	589	Identity:	354/589 - (60%)
Similarity:	445/589 - (75%)	Gaps:	4/589 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIFDA 70
            |:|||||||||||.|::...||||.||||.|||||:|||||:|||:|||||||.||||.||:|||
pombe     8 AIGIDLGTTYSCVAVWETANVEIIPNDQGARTTPSFVAFTETERLVGDAAKNQAAMNPRNTVFDA 72

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYL 135
            |||||||::|...|.|:|||||:|...||.|.|.|.|.||:|.|..:|:|:||||||:|.:||.|
pombe    73 KRLIGRRYEDPETQKDIKHWPFKVIDNNGIPTIEVNYLGEKKQFTAQEISAMVLTKMKEISEAKL 137

  Fly   136 GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFDL 200
            ...|..||:||||||:||||.||||||||||||||||||||||||||||||.:....:|||||||
pombe   138 NKRVEKAVITVPAYFSDSQRAATKDAGAIAGLNVLRIINEPTAAAIAYGLDAKSDKPKNVLIFDL 202

  Fly   201 GGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRT 265
            ||||||||:|.|:.|:|||.|||||||||||||||.||.||:|||:||.|.|:..:.|||||||:
pombe   203 GGGTFDVSLLKIQGGVFEVLATAGDTHLGGEDFDNALVEHFIQEFKRKQKIDISDDPRALRRLRS 267

  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQ 330
            |||||||.|||.||.::|:|||..|:||.:|:||||||::|...|:.|::||||.|:|:|:.|..
pombe   268 ACERAKRALSSVTQTTVEVDSLSNGIDFSSSITRARFEDINATTFKATIDPVAKVLKDSKVPKAD 332

  Fly   331 IHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAIL-HGDKSEAVQDLLLL 394
            :||||||||||||||||||:.|||:|:.||||||||||||||||||||:| :...|:..||||||
pombe   333 VHDIVLVGGSTRIPKVQRLVSDFFDGRALNKSINPDEAVAYGAAVQAAVLTNKADSDKTQDLLLL 397

  Fly   395 DVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKF 459
            ||.|||||:...|.|...:..|||.|||.:.:.|||.||||..|...|::|||....:|..||:|
pombe   398 DVVPLSLGVAMEGNVFGVVCPRNTPIPTIKKRTFTTVADNQTTVTFPVYQGERVNCAENEPLGEF 462

  Fly   460 ELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEA 524
            :|:.|||.|||..::|.||::||||||.|||:||:||:...|.|||..|.||...|:.|:.:|:.
pombe   463 QLTGIPPMPRGQAELEATFELDANGILKVTAVEKTTGRSAHIEITNSVGHLSSTKIQEMIENADK 527

  Fly   525 YRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWL---DANQL 586
            ::|.|:....::.||:|||||...:.:|:.:.::..:....|:..|:.:.:|.::.|   |.|..
pombe   528 FKQQDKDFAKKLEAKSQLESYISNIETTISEPNVMMKLKRGDKSKIEAQLAECMSQLELEDTNTD 592

  Fly   587 AERQ 590
            |.|:
pombe   593 ALRK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	354/589 (60%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	265/375 (71%)
sks2	NP_595438.1	HSP70	8..613	CDD:278441	354/589 (60%)
		HSPA1-2_6-8-like_NBD	8..383	CDD:212675	264/374 (71%)
		BAR	<503..>603	CDD:299863	28/94 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.670